The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH

Gareth W. Hughes, Caroline Ridley, Richard Collins, Alan Roseman, Robert Ford & David J. Thornton  Abstract The polymeric mucin MUC5B provides the structural and functional framework of respiratory mucus, conferring both viscoelastic and antimicrobial properties onto this vital protective barrier. Whilst it is established that MUC5B forms disulfide-linked linear polymers, how this relates to their packaging in secretory granules, and their … Continue reading The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH