Body Clock Proteins, Macrophages and Moreless

Reading about new research results of a study into Inflammation and the body clock, here :

Researchers at RCSI and Trinity College Dublin have revealed insights into how the body clock controls the inflammatory response, which may open up new therapeutic options to treat excess inflammation in conditions such as asthma, arthritis and cardiovascular disease. By understanding how the body clock controls the inflammatory response, we may be able to target these conditions at certain times of the day to have the most benefit. These findings may also shed light on why individuals who experience body clock disruption such as shift workers are more susceptible to these inflammatory conditions.

The body clock, the timing mechanism in each cell in the body, allows the body to anticipate and respond to the 24-hour external environment. Inflammation is normally a protective process that enables the body to clear infection or damage, however if left unchecked can lead to disease. The new study, led by researchers at Dr. Annie Curtis’s Lab at RCSI (Royal College of Surgeons in Ireland) in partnership with Prof. Luke O’Neill’s Lab at Trinity College Dublin, is published in the Proceedings of the National Academy of Sciences (PNAS), a leading international multidisciplinary scientific journal.

Dr Annie Curtis, Research Lecturer in the Department of Molecular and Cellular Therapeutics at RCSI and senior author, explained that: “Macrophages are key immune cells in our bodies which produce this inflammatory response when we are injured or ill. What has become clear in recent years is that these cells react differently depending on the time of day that they face an infection or damage, or when we disrupt the body clock within these cells”.

Dr. Jamie Early, first author on the study, said: “We have made a number of discoveries into the impact of the body clock in macrophages on inflammatory diseases such as asthma and multiple sclerosis. However, the underlying molecular mechanisms by which the body clock precisely controls the inflammatory response were still unclear. Our study shows that the central clock protein, BMAL1 regulates levels of the antioxidant response protein NRF2 to control a key inflammatory molecule called IL-1β from macrophages.”

“The findings although at a preliminary stage, offers new insights into the behaviour of inflammatory conditions such as arthritis and cardiovascular disease which are known to be altered by the body clock”, added Dr Early.

Funded by Science Foundation Ireland, the research was undertaken in collaboration between RCSI, Trinity College Dublin and the Broad Institute in Boston, USA.


The paper, The Circadian Clock Protein BMAL1 Regulates IL-1β in Macrophages via NRF2, will be published on Monday, August 20, at 3 pm US ET/8pm GMT.


ChooseLife Thoughts : This is a good research area, Moreless used to repeatedly state ‘no proteins 4-6 hours before bed, no significant protein 6 hours ideally‘.

It rang true to me, he said if you eat significant protein before bed, your Autonomic Nervous System would potentially be held off from repair in key early sleep phases, as the digestion of proteins require more Oxygen than say vegetables/salad. If digestion is incomplete at the point of sleep, this triggers the endocrine system to focus blood flow there, rather than supplying electromagnetic force to tissue repair, recovering the adrenals (which happens between 11pm-1am it is believed), and other vital parasympathetic/R&R functions.

Coupling this information of Moreless, with Carey Reams suggestion, to just eat salad largely at dinner (with a good olive oil as dressing, he claimed this cleared the digestive tract well, creating a gelatine like substance to help avoid foods sticking, setting you up for the following day), light foods at dinner, which very likely shaped the base of Moreless thinking. They dovetail this research.


Brain pH Linked to Alzheimers

pH imbalance in brain cells may contribute to Alzheimer’s disease

Study identifies potential drug targets to reverse problem found in tiny organelles in astrocytes

August 2, 2018
Johns Hopkins Medicine
Scientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer’s disease may be a simple imbalance in acid-alkaline — or pH — chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells.

Full Article =

ChooseLife notes = Interestingly the pH of 6.21 was the average of those not affected, this is close to the tissue pH Carey Reams suggests we should be trying to be within (Below is a scheme showing the concept pH Range Of Acceptance):

Previously, I have seen some evidence, which Moreless cited, which showed that Fish demonstrate levels of Mercury tissue saturation, not chiefly based on the mercury levels of the water, but rather the pH. This strongly suggests that it is the pH which was the chief uptake driver of Mercury into tissue, not the levels of Mercury as you may assume (the studies showed a lake with lower pH and lower Mercury had Fish with higher levels of Mercury than another lake with higher pH and higher Mercury).

“Of interest, recent studies have shown that mercury levels in
water in a water-sediment partition system of high pH value were
higher than those in a comparable system of low pH (MATSUMURA et
al. 1972). Thus, we have the enigma of lower mercury content in
fish inhabiting waters of higher pH and comparably higher mercury
concentration. It appears that mercury concentration in water is
not the only factor controlling the amount of mercury in fish.” Full

This leads me to ponder, if similar is happening in our brains, with Aluminium starting to become more neuro-toxic as our pH drops? 

This similar principle, applied to dental Mercury, may explain why some do not suffer with amalgams, yet many feel they do? Perhaps those who suffer have generally lower saliva pH, which triggers the harmful effects, often believed to be from this element. 

(Alzheimers & Aluminium research = Link)