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pH : The Toxicity Arrow Piercing Modern Society

By ChooseLife

Why is it, that many modern diseases of high prevalence, affect some people and not others?

Well? It can’t be the Mercury, they said, as otherwise everyone would get it.

Well? It can’t be the Fluoride, our body needs and produces that.

Well? It can’t be the Aluminium, it’s prevalence means we have historical digestive capability to cope they say, it is such tiny amounts given medically they say.

Well? It can’t be poor diet, the body has homeostasis to set right such problems.

Until we start to look at life from another perspective, illness may hurtle towards us, regularly, with ever more velocity. Given the continual decline in soil quality, producing less vital fruits, vegetables, meats, nuts and seeds (even herbs). The problem is exacerbated by the emergence of processed sugars and flours, which in most guises are antagonistic to our biochemistry, chiefly Calcium (Magnesium, Iodine et al.), which might make a simple walk in the park dangerous, simply a cut or graze might cause an infection.

Why is it so? pH

Aluminium Toxicity pH Variable
Toxicity decreased with increasing pH 5.0-6.0 found most toxic
The Acid Test of Fluoride: How pH Modulates Toxicity
Low pH Saliva will make Fluoride progressively toxic to you.
Extracellular Brain pH and Outcome following Severe Traumatic Brain Injury.
This links the issues all together.
Low brain pH may play a role in autism, other conditions
Infection and pH UTI
Brain pH Linked to Alzheimers

When fluids in the endosome become too acidic, the cargo is trapped within the endosome deep inside the cell. When the endosome contents are more alkaline, the cargo lingers at the cell’s surface for too long.

They found that mouse cell lines containing the Alzheimer’s disease gene variant had more acidic endosomes (average of 5.37 pH) than cell lines without the gene variant (average of 6.21 pH).


Pretty compelling picture.




The above research, clearly demonstrate that it is when pH of matter falls (or rises) out of its environmental bounds, matter starts to decay and becomes unable to buffer stronger opposing electromagnetic forces, demonstrated by the papers above showing it is pH dropping which really appears to make Mercury, Aluminium & Fluoride (Excessively) Toxic, even in the ‘low’ amounts suggested as safe by regulatory authorities.

This ticks all the boxes of “why some and not others” with Dental Amalgam, Vaccination related side effects (Aluminium Hydroxide pH 9.5 injected into an individual with a tissue pH in the 5.0-5.5 range is hugely more dangerous than an individual in the safer zone of 6-7 – the author believes this is the propellant of many debilitating diseases, the data presented in this article supports this theory).

So, we have a period eating poorly, high sugars, processed carbs, processed meats/dairy. Any part of this combination, as a core part of diet, to the wrong individual, will make the tissue pH plummet, it is all there in the studies. If individuals live like this, then the smallest of environmental pollutants may become lethal (because we lack the buffer system, which may allow the host sufficient robustness to cope, this is what gives the lymphatic system the traction to cycle these toxins out).

If you raise the pH of your terrain (eat more greens & more Omega 3!), you suddenly become less prone to infection and heavy metals become less toxic to you, it is almost like God was trying to pass a message to humanity through Carey Reams, isn’t it?

Higher Fruit and Vegetables, less meat, 22,000 people studied, raises pH of Urine:

 In conclusion, a more alkaline diet, higher fruit and vegetable and lower meat intake were related to more alkaline urine with a magnitude similar to intervention studies

https://www.ncbi.nlm.nih.gov/pubmed/18042305/

Effect of urine pH changed by dietary intervention on uric acid clearance mechanism of pH-dependent excretion of urinary uric acid

High meat after 3 days, urine pH drops to 5.9

High Fruit Veg after 3 days, urine pH rises to 6.7

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406944/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976726/

Study shows mean pH of Urine drops from 6.7 to 5.5 in people suffering diarrhea

https://www.ncbi.nlm.nih.gov/pubmed/7702787

CONCLUSIONS:
Low urine pH is significantly associated with abnormal glucose tolerance; therefore, measuring urine pH might prove useful for identifying patients at high risk for diabetes.

https://www.ncbi.nlm.nih.gov/pubmed/29144608

Metabolic abnormalities in autosomal dominant polycystic kidney disease

The majority of sufferers have urine pH below 5.5

https://academic.oup.com/ndt/article/30/2/197/2337167

Simply testing someones pH, may show clearly whether they have the biological capability, at all, to repel these neurotoxins, could life be so simple? (not that I advocate vaccination at all personally, or any unnecessary exposure to these nasty elements, full stop). However, If I was a worried parent, before deciding on vaccination I would test my childs urine pH, to get an indicator the gravity of danger my child faces. Then if their pH was below 6.0 maybe feed them more greens and good oil for a few weeks, test again, then make a more informed decision. This seems eminently sensible.

ChooseLife : pH balancing is the middle path. Developed from thoughts of Randall David Dew, it is time this great man was set free.

To note, the pH of the ‘high fruit and vegetable diet’, is higher than Carey Reams suggested we should attain, to produce perfect friction (or metabolic energy release between anionic and cationic elements in the body), he suggests 6.4 is perfect urine pH, the same for Saliva pH, which together denote the overall pH terrain status (the mean of 2x Urine 1x Saliva).

As the studies above all show, once your pH is in the range below 5.5 biological function becomes very difficult to sustain, without disease and illness. This dovetails Carey Reams profound teachings about Biological Ionisation, where he demonstrated multiple nutrients cannot be absorbed when the terrain is in this low pH condition (or excessively high also, as shown).

This is just a reflection, this is not advice.

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Aluminium Toxicity pH Variable

Long-term toxicity to aquatic invertebrates

Toxicity decreased with increasing pH

Aluminium toxicity was reduced at high pH, but a larger reduction was observed when changing pH from 6 to 7 than from 7 to 8. 

https://echa.europa.eu/registration-dossier/-/registered-dossier/15529/6/2/5

Literature Review: Six long-term chronic toxicity studies to two species of aquatic invertebrates(Ceriodaphnia dubia and Daphnia magna) were identified as acceptable studies.

See Table # “Overview of long-term effect on aquatic invertebrates” (below). ECr10s were calculated using raw data provided from each study using the statistical program Toxicity Relationship Analysis Program (TRAP) version 1.10 from the US EPA National Health an Environmental Effects Research Laboratory (NHEERL).

All other endpoints were as reported in each study. NOECs and EC10s ranged from 0.076 to 4.9 mg Al/L and 0.021 to 0.997 mg Al/L, respectively. Water quality data for these studies suggest a direct relationship between toxicity and pH, hardness, and DOC. For studies that experimentally manipulated water quality (e.g., CIMM 2009 and 2010a ), toxicity decreased with increasing pH, hardness, and DOC.

Aluminum and water: reaction mechanisms, environmental impact and health effects

Aluminum naturally occurs in waters in very low concentrations. Higher concentrations derived from mining waste may negatively affect aquatic biocoenosis. Aluminum is toxic to fish in acidic, unbuffered waters starting at a concentration of 0.1 mg/L. Simultaneous electrolyte shortages influence gull permeability, and damage surface gull cells. Aluminum is mainly toxic to fish at pH values 5.0-5.5. Aluminum ions accumulate on the gulls and clog these with a slimy layer, which limits breathing. When pH values decrease, aluminum ions influence gull permeability regulation by calcium. This increases sodium losses. Calcium and aluminum are antagonistic, but adding calcium cannot limit electrolyte loss. This mainly concerns young animals. An aluminum concentration of 1.5 mg/L turned out to be fatal to trout. The element also influences growth of freshwater bony fish.

Full : https://www.lenntech.com/periodic/water/aluminium/aluminum-and-water.htm#ixzz5xTLuYJaV

Choose Life : Considering what is happening in the world in these times, these studies about aquatics, helps link so much together. This post will be updated as I find more data on this, just started a new job so bare with me please.

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Carey Reams – Kathryn Kuhlman – The Holy Spirit Healings

4minutes 35seconds in, man very similar to Carey Reams talks to Kuhlman, about being able to hear again attending that fateful night.
The Holy Spirit Performing Miracles Through Kathryn Kuhlman
Ten healing miracles

It is a real shame that the Author didn’t include Carey Reams case with Kuhlman in his book. In ‘Choose Life Or Death’ Reams recounts that he was at the brink of death, after suffering shrapnel piercing, and lodging in, his Pancreas during military service.

This genius biochemist was not able to heal himself, he reflected that he felt he was in his last week of life, this is what precipitated his attendance of Kathryn Kuhlmans Healing Service. Reams tells how he had no faith in a healing, but was given glowing reference by someone, and everything else had failed him.

As we see at the very start of the video at the top, Reams was healed by the Holy Spirit!

After this point in Reams life he appears to change quite significantly, he talks of focusing on healing a boy ceaselessly, for days, like a deep meditative reflection (it is my belief that in such situations, the person may be able to connect/touch the universal consciousness, people who encounter near death, such as Reams, appear to perhaps create a soul version of ‘muscle memory’, where subsequently they gain a significant enhancement in ability to connect again to this source).

He comes to a profound realisation, after this sequence of events, that he understands a set of biological variables, which when he tests with some reasonably simple tools, can deduce the biological energy status of the host. This is what he terms Reams Biological Theory of Ionisation (RBTI). This developed understanding and testing methodology, coupled with his background as an agronomist, saw him become famous locally.

Two local Hospitals began to refer lost causes to him, during the next years:

Reams said: We tested over 24,000 people in 1970-1971. Over 10,000 of those came to us as “terminal”. We lost five. Those five we couldn’t keep alive for 30 days. (10K were referred to him directly by doctors for hopeless cases. He worked directly with a Florida hospital and doctors, often with the “hopeless cases.”)

1 hour 10 minutes Carey Reams Full Praise For Healing
Beautiful
Kuhlman speaking on receiving her honorary Doctorate
Mental Attitude

Choose Life : I believe in miracles.

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The Acid Test of Fluoride: How pH Modulates Toxicity

Abstract

Background

It is not known why the ameloblasts responsible for dental enamel formation are uniquely sensitive to fluoride (F−). Herein, we present a novel theory with supporting data to show that the low pH environment of maturating stage ameloblasts enhances their sensitivity to a given dose of F−. Enamel formation is initiated in a neutral pH environment (secretory stage); however, the pH can fall to below 6.0 as most of the mineral precipitates (maturation stage). Low pH can facilitate entry of F− into cells. Here, we asked if F− was more toxic at low pH, as measured by increased cell stress and decreased cell function.

Methodology/Principal Findings

Treatment of ameloblast-derived LS8 cells with F− at low pH reduced the threshold dose of F−required to phosphorylate stress-related proteins, PERK, eIF2α, JNK and c-jun. To assess protein secretion, LS8 cells were stably transduced with a secreted reporter, Gaussia luciferase, and secretion was quantified as a function of F− dose and pH. Luciferase secretion significantly decreased within 2 hr of F− treatment at low pH versus neutral pH, indicating increased functional toxicity. Rats given 100 ppm F− in their drinking water exhibited increased stress-mediated phosphorylation of eIF2α in maturation stage ameloblasts (pH<6.0) as compared to secretory stage ameloblasts (pH∼7.2). Intriguingly, F−-treated rats demonstrated a striking decrease in transcripts expressed during the maturation stage of enamel development (Klk4 and Amtn). In contrast, the expression of secretory stage genes, AmelX, Ambn, Enamand Mmp20, was unaffected.

Conclusions

The low pH environment of maturation stage ameloblasts facilitates the uptake of F−, causing increased cell stress that compromises ameloblast function, resulting in dental fluorosis.

Full : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010895

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Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: A possible role of fluoride and aluminum

Conclusions : The etiology and pathogeneis of ASD are not well understood. Autism Spectrum Disorders comprise a complex of clinical syndromes found predominantly in infants and younger people consisting of disturbances in cognition and comprehension, communication disorders, epilepsy, and behavior that have an underlying common pathology of neurodegeneration of the cerebellar Purkinje cells and other areas of the brain. Other studies in humans have shown chronic inflammatory changes in the brain, particularly in the cerebellum, and involvement of the microglia in this pathology.

Our review presents evidence suggesting a hypothesis unifying the syndromes in ASD. The clinical as well as pathological findings of the ASD have a set of pathological events with the common denominator being immunoexcitotoxicity leading to neurodegeneration and abnormalities in the connectome, particularly in developing brains in the neonate and young with evidence that explains the clinical presentation of ASD.

Our hypothesis is supported by experimental evidence from animal models and by some clinical testing and pathology studies that give credibility to the concept of immunoexcitotoxicity as the underlying cause of ASD. A great number of conditions can trigger both the inflammatory and the excitotoxic cascade, including sequential vaccination, infections, hypomagnesemia, ROS, RNS and LPP, fluoride and Al3+ as well as a number of other neurotoxic metals and industrial chemicals. Chronic activation of the brain’s immune system increases extracellular glutamate levels sufficiently to trigger the excitotoxic cascade, which in conjunction with inflammatory cytokines and prostaglandins, magnifies the damaging effects of both. This mechanism explains most of the features of the ASD, including the behavioral difficulties, language problems, repetitive behaviors, intellectual delay, and episodic dyscontrol of anger. In addition, these mechanisms explain the pathological findings as well, including the changes in the cerebellum, abnormalities in connectivity and the widespread activation of microglia and astrocytes. It also explains why ASD has not disappeared despite the removal of mercury from most childhood vaccines, since excessive immune activation is the initiating and sustaining event in ASD. Evidence is presented that the abundance of fluoride added to the water worldwide and the widespread availability of aluminum particularly to infants and young children through aluminum containing vaccinations, singly or together as aluminofluoride can be potent factors in producing the condition of immunoexcitotoxicity that leads to the pathological changes seen in ASD. The vaccination program should be evaluated to reduce the excessive stimulation of immature immune system and to replace Al3+-adjuvants.

We have also reviewed studies that indicate that fluoride and Al3+, as ubiquitous environmental and food-derived toxins, can exacerbate the pathological and clinical problems of ASD. In synergistic action as AlF4− these elements induce numerous chronic pathophysiological consequences at several times lower concentrations than either Al3+ or fluoride acting alone. AlF4− may evoke several signaling disorders and act as an endocrine disruptor. Moreover, most of the excitotoxic events may enhance the subclinical pathological alterations and/or the genetic susceptibility seen in ASD. The full genetic potential of the child for brain and mental development may be also compromised due to deficiency of micronutrients.

Our immunoexcitotoxic hypothesis opens the door to a number of new modes of prevention and amelioration of ASD. Elimination of various sources of fluoride and Al3+ in early development and consumption of a diet containing essential nutrients and antioxidants have been shown to be beneficial to brain function. As a multifaceted disorder, ASD requires a multifaceted approach, one that should include the protection against excitotoxicity, as well as the protection against microglial activation.

There are several experimental studies that can be constructed to test the immunoexcitotoxic hypothesis, especially as regards vaccines. Such a study would require the use of non-human primates at various stages of development, from intrauterine life to early post-natal development corresponding to human neurodevelopment during vulnerable neurodevelopmental milestones. The study would follow the vaccine schedules used with human newborns and pre-schoolers. One would need to use the exact vaccines used in the human vaccine schedules but of comparable doses based on weight.

To measure microglial activation in response to the vaccines, it would be necessary to use microglial activation PET scanning techniques at various time schedules before and following the vaccines. Newer microglial activation PET scanning techniques are being developed that hold the possibility of differentiating between M1 and M2 microglial activation phenotypes. Long-term follow-up scanning would be necessary to delineate prolonged microglial activation as has been observed in cases of autism. Measure of glutamate levels in the affected areas of the brain should also be conducted, perhaps in a separate set of monkeys to prevent inadvertent activation of local microglia. More extensive studies could be envisioned, such as measures of EAATs, glutaminase, and NADPH oxidase within affected brain areas in response to vaccination.

In addition, studies should be conducted measuring the aluminum, fluoride and aluminofluoride complex concentration in the affected areas of the brain in autopsied cases of autism. This should include the various cell types as well as cellular compartments. This could also be done experimentally in the non-human primate studies using human vaccines described above. Controls could establish the levels of these toxicants to establish the baseline levels in non-vaccinated animals.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909100/

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Floridation Canada Study

https://www.sciencemag.org/news/2019/08/drinking-fluoridated-water-during-pregnancy-may-lower-iq-sons-controversial-study-says

Either way, “It’s a potential bombshell,” says Philippe Grandjean, an environmental health researcher at Harvard University who wasn’t involved in the work.

Why is it a bombshell? given other studies have shown the same results?

Because these scientists fear industry pressure and funding strangulation. Since I found this research I have duck-duck-go searched multiple articles and they are all laced with ‘controversial study’ and ‘too early to start making claims about neurotoxicity, based on one study’, yet this is not the first, there are multiple studies.

Mexico – https://ehp.niehs.nih.gov/doi/10.1289/ehp655

In this study, higher prenatal fluoride exposure, in the general range of exposures reported for other general population samples of pregnant women and nonpregnant adults, was associated with lower scores on tests of cognitive function in the offspring at age 4 and 6–12 y.

India – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285601/

It is concluded that IQ level was negatively correlated with fluoride level in drinking water. Factors that might affect children’s IQ need to be considered, and it is necessary to devise solutions for preventing the harmful effects of excessive intake of fluoride ion to the body.

Iran – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484826/

Children residing in areas with higher than normal water fluoride levels demonstrated more impaired development of intelligence. Thus, children’s intelligence may be affected by high water fluoride levels.

China – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852689/

Children’s intelligence and growth can be affected by high concentrations of As or fluoride. 

ChooseLife Notes : Bombshell to who exactly?

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Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6–12 Years of Age

Abstract

Background:

Some evidence suggests that fluoride may be neurotoxic to children. Few of the epidemiologic studies have been longitudinal, had individual measures of fluoride exposure, addressed the impact of prenatal exposures or involved more than 100 participants.

Objective:

Our aim was to estimate the association of prenatal exposure to fluoride with offspring neurocognitive development.

Methods:

We studied participants from the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) project. An ion-selective electrode technique was used to measure fluoride in archived urine samples taken from mothers during pregnancy and from their children when 6–12 y old, adjusted for urinary creatinine and specific gravity, respectively. Child intelligence was measured by the General Cognitive Index (GCI) of the McCarthy Scales of Children’s Abilities at age 4 and full scale intelligence quotient (IQ) from the Wechsler Abbreviated Scale of Intelligence (WASI) at age 6–12.

Results:

We had complete data on 299 mother–child pairs, of whom 287 and 211 had data for the GCI and IQ analyses, respectively. Mean (SD) values for urinary fluoride in all of the mothers (n=299n=299) and children with available urine samples (n=211n=211) were 0.90 (0.35) mg/L0.90 (0.35) mg/L and 0.82 (0.38) mg/L0.82 (0.38) mg/L, respectively. In multivariate models we found that an increase in maternal urine fluoride of 0.5mg/L0.5mg/L (approximately the IQR) predicted 3.15 (95% CI: −5.42−5.42, −0.87−0.87) and 2.50 (95% CI −4.12−4.12, −0.59−0.59) lower offspring GCI and IQ scores, respectively.

Conclusions:

In this study, higher prenatal fluoride exposure, in the general range of exposures reported for other general population samples of pregnant women and nonpregnant adults, was associated with lower scores on tests of cognitive function in the offspring at age 4 and 6–12 y. https://doi.org/10.1289/EHP655

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Dr. Tuesday Lobsang Rampa

The books of Dr. Lobsang Rampa have introduced many thousands of people in the west to buddhist teachings and spiritual and metaphysical knowledge. Dr. Rampa was amongst the first eastern teachers to make this knowledge accessible to westerners in an easily understandable and enjoyable format and a forerunner of today’s buddhist teachers such as Sogyal Rinpoche and Ringu Tulku.

Dr. Rampa was a prolific author – his first book “The Third Eye” published in 1955, was followed by 23 more, and he continued to write until shortly before his death in Canada in 1981.

Why not read one and investigate Dr. Rampa’a writings for yourself? This page gives an outline of the content of many of the Rampa books and gives extracts to get a flavour of the books.

Selection of books by Dr. Tuesday Lobsang Rampa – free downloads:


Click to view online in a separate window, or right-click and choose “save target as” to download to your computer. The files are in Word format and are between 600k and 1.1Mb in size.

The above books tell the story of Dr. Rampa’s life, the following books expand on buddhist teachings and spiritual and esoteric knowledge….

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Omega-3 polyunsaturated fatty acid inhibits the malignant progression of hepatocarcinoma by inhibiting the Wnt/β-catenin pathway

F.-Z. Chang, Q. Wang, Q. Zhang, L.-L. Chang, W. Li

Department of Gastroenterology, Qingdao Hiser Medical Group, Qingdao, China. Leewei22011@163.com

OBJECTIVE: Omega-3 polyunsaturated fatty acid (ω-3 PUFA) has been found to possess anti-cancer potential in previous studies. However, the underlying mechanism of ω-3 PUFA in protecting hepatocarcinoma has not been fully elucidated. This study aims to explore the function of ω-3 PUFA in the development of hepatocarcinoma and its potential mechanism.

PATIENTS AND METHODS: In this study, human hepatocarcinoma cell line Hep G2 was treated with ω-3 PUFA. Cell counting kit-8 (CCK-8) and cell cloning assay were applied to detect the proliferation of Hep G2 cells. In addition, flow cytometry was performed to analyze the cell cycle and apoptosis rate. At the same time, the effect of ω-3 PUFA on invasion and metastasis of hepatocarcinoma cells were analyzed by transwell assay. Moreover, protein levels of key factors in Wnt/β-catenin pathway were detected by Western blot.

RESULTS: Cell proliferation of Hep G2 cells was decreased after ω-3 PUFA treatment in a time- and dose-dependent manner. CCK-8 assay showed that the IC50 value was 12.8 ± 0.67 μmol/L, 8.8 ± 0.43 μmol/L and 4.6 ± 0.42 μmol/L after ω-3 PUFA treatment for 24 h, 48 h and 72 h, respectively. Besides, ratio of Hep G2 cells blocked at G2/M phase after ω-3 PUFA treatment (5 μmol/L, 10 μmol/L and 20 μmol/L) was increased in a dose-dependent manner (p<0.05). Meanwhile, ω-3 PUFA could increase cell apoptosis (p<0.05) and inhibit cell proliferation. In addition, ω-3 PUFA reduced protein expressions of total, cytoplasmic and nuclear β-catenin in Hep G2 cells, indicating that the Wnt/β-catenin pathway is inhibited. Decreased expression levels of Dvl-2, Dvl-3, GSK-3β (p-ser9), c-myc and survivin, and increased expression levels of GSK-3 (p-tyr216) and Axin-2 were observed in Hep G2 cells treated with ω-3 PUFA, but no significant alteration in total GSK-3β protein level was observed (p>0.05).

CONCLUSIONS: Omega-3 PUFA regulates the malignant progression of hepatocarcinoma by inhibiting proliferation and promoting apoptosis of hepatocarcinoma cells via Wnt/β-catenin signaling pathway.

Sourced = https://www.europeanreview.org/article/15504

ChooseLife Notes : This is overlapping data, from the studies on carcinoma apoptosis, which have been compiled here = http://chooselife.co.uk/index.php/flax/ Though this study does not make clear the form of Omega3 used.