Coronavirus leads to Lymphopenia in 82% of patients + Nutrition to enhance the body against Lymphopenia

A recent study from the lead scientific advisor on Coronavirus, has found that 82% of those studied with the virus developed Lymphopenia (abnormally low lymphocytes in the blood)

Dr Zhong Nanshan, who discovered the SARS coronavirus in 2003 is the leading advisor in investigating and managing the current coronavirus crisis.

Lymphopenia, which is a condition where a specific white blood cell that is part of the body’s first-line defence against diseases is dramatically reduced.

https://www.medrxiv.org/content/10.1101/2020.02.06.20020974v1

So, it may be very pertinent to look at the known nutritional elements which nourish the bodies own Lymphocyte making capability, as a means of focus should you feel the need to prepare, eat (or supplement) whilst your body is fighting this Virus.

Here is a strong, concise overview of such dietary elements:

Lymphocyte Nutritional Support:

Dietary Guidelines for a Better Lymphocyte Count
You may want to know how to increase lymphocytes naturally. A healthy, nutrient-rich diet can go a long way toward boosting lymphocyte levels. This will provide your immune system with everything it needs to fight off viruses and bacteria that can potentially lead to low lymphocyte levels.

The following is a dietary guideline to follow to help your body improve its lymphocyte count.

  • Eat lots of lean protein: When the body doesn’t get enough protein, this leads to fewer white blood cells. As a result, you can increase lymphocyte production when you eat protein-rich foods such as grass-fed meats like poultry and beef, organic eggs, wild-caught fish and seafood, and legumes.
  • Avoid foods high in trans and saturated fats: These fats thicken lymphocytes; as such, reducing trans and saturated fat consumption can help improve immune system health. Avoid unhealthy fats such as margarine, fried foods, hydrogenated oils, and processed baked goods.
  • Consume healthy fats: Omega-3 fatty acids, on the other hand, will increase your lymphocyte count. Include omega-3 fatty acid foods such as avocado, ground flaxseed, hemp seeds, chia seeds, walnuts, sardines, albacore tuna, white fish, Alaskan salmon, herring, and Atlantic mackerel in your diet.
  • Eat foods high in beta-carotene: Beta-carotene helps boost lymphocyte production. Foods rich in beta-carotene include carrots, sweet potatoes, butternut squash, romaine lettuce, and spinach.
  • Eat zinc-rich foods: Zinc is needed to make lymphocytes. It also increases levels of NK cells and T cells, which strengthens your immune system. Foods high in zinc include oysters, asparagus, collard greens, spinach, broccoli, sesame seeds, and pumpkin seeds.
  • Consume foods high in vitamin C: Vitamin C is known to increase the production of white blood cells such as lymphocytes. Foods high in vitamin C include bell peppers, parsley, kale, oranges, raspberries, tomatoes, and celery.
  • Eat foods loaded with vitamin D: Not getting enough vitamin D can lower lymphocyte levels and weaken your immune system. Foods rich in vitamin D include organic eggs, raw milk, wild-caught salmon, sardines, mackerel, and tuna.
  • Eat foods high in vitamin E: Vitamin E supports production of NK cells and B cells. Foods rich in vitamin E include sunflower seeds, almonds, kale, spinach, olives, asparagus, and collard greens.
  • Eat selenium-rich foods: Selenium helps the body produce more white blood cells. Foods high in selenium include cod, shiitake mushrooms, salmon, tuna, eggs, oats, and broccoli.
  • Eat more garlic: Garlic is known to boost white blood cell production, which increases the number of NK cells. Purchase fresh, powdered, or dried garlic, and use it in your cooking daily.
  • Drink more green tea: Green tea compounds can boost immunity by fighting viruses that deplete white blood cells.
www.doctorshealthpress.com

Source = Low Lymphocyte Count (Lymphocytopenia)

Low lymphocyte count, also known as lymphocytopenia, is a cause for concern because when lymphocytes (a type of white blood cell) are low, the body’s ability to repel infections is weakened.

By Dr. Richard Foxx, MD

ChooseLife : Of Course, I am always focused on the Acid/Alkaline balancing aspects in life, so this is not to discount the strong evidence that initial infectivity and severity it almost certain to be controlled by the hosts pH, if your tissue at the site of infection is below 7 you are much more likely to become infected, if 6 or lower it has been demonstrated in previous strains that the infectivity is 10x higher, Alkaline eating and supplementation is something I am very focused on for me and my family.

THIS SHOULD NOT BE CONSTRUED AS MEDICAL ADVICE.

pH – CoronaVirus and the SO2 Madness

Dear All,

When I first read about the CoronaVirus (2019-nCoV), my immediate reaction was to DuckDuckGo search pH dependency = https://duckduckgo.com/?q=coronavirus+ph+dependency&atb=v121-1&ia=web

This immediately gave me several bits of vital information, to understand the situation from a biological and nutritional perspective. By looking at historical studies, to see some baseline characteristics:

  • In this report, we show that the SARS-CoV S glycoprotein mediates viral entry through pH-dependent endocytosis.  Reference : 1
  • In contrast, influenza and Ebola viruses are prototypes for viruses that utilize a pH-dependent endocytotic pathway (43). To determine the pathway utilized by the SARS-CoV, the pH dependence of the SARS-CoV S-pseudotyped lentiviral vector was analyzed. Addition of ammonium chloride, which prevents acidification of the endosome, caused a dose-dependent reduction in viral entry (Fig. (Fig.1B,1B, left) at concentrations similar to those described for other pH-dependent viral glycoproteins (31143). This effect was also observed with another inhibitor of endosomal acidification, bafilomycin, also in a dose-dependent fashion (Fig. (Fig.1B,1B, right). Reference : 1
  •     The World Health Organization has concluded that SARS is produced by a new virulent strain of coronavirus. Specific research on the possible pH dependency of the SARS virus has not yet been done.  It is well known that coronavirus infectivity is exquisitely sensitive to pH.  For example, the MHV-A59 strain of coronavirus is quite stable at pH 6.0 (acidic) but becomes rapidly and irreversibly inactivated by brief treatment at pH 8.0 (alkaline).  Human coronavirus strain 229E is maximally infective at pH 6.0.  Infection of cells by murine coronavirus A59 at pH 6.0 (acidic) rather than pH 7.0 (neutral) yields a tenfold increase in the infectivity of the virus. Reference : 2
  • Infection of susceptible murine cells with the coronavirus mouse hepatitis virus type 4 (MHV4) results in extensive cell-cell fusion at pHs from 5.5 to 8.5. The endosomotropic weak bases chloroquine and ammonium chloride do not prevent MHV4 infection. In marked contrast, we have selected variants from a neural cell line persistently infected with MHV4 which are entirely dependent on acid pH to fuse host cells and are strongly inhibited by endosomotropic weak bases…  Wild-type S induced cell-cell fusion at neutral pH, whereas variant S required prolonged exposure to acidic pH to induce fusion… These findings demonstrate that the pH dependence of coronavirus fusion is highly variable and that this variability can be determined by as few as three amino acid residues. Reference : 3

So, we can see above, that in most cases (all that I can find), scientific studies are showing multiple variants of CoronaVirus are completely pH driven, in terms of susceptibility (most cases, sadly only pH range 5.5-8.5 tested, maybe scientists could test Magnesium Hydroxide = 10.5, to show if higher pH is protective/preventative) and intensity of infection (seemingly all), though there are variations in pH levels required to neutralise the impacts.

Now, initially I just doubled down on my thoughts on Alkalising my own terrain and looking after my childrens via diet and key suppliments. However, as the stories became more and more alarming, things took a dramatic turn.

Sunday 9th February 2020 Reports emerged of an outrageous happening in China

Using Windy.com it was discovered that rates of Sulphur Dioxide above Wuhan were reading 1351PPB

Now, this alone, suggests strongly that there has been a huge upsurge in burning of organic matter which releases SO2, leading to speculation that high levels of cremation are occurring. The data is contested by some, claims made that this comes from a ‘modelling’ or predictive site, so the numbers cannot be trusted (maybe true, but they are a strong indicator of ‘in the range of’, if not exact in the measurements. This may have some validity, however, another site, https://earth.nullschool.net/ showed similar numbers to https://windy.com even when you look without the forecast running you still get numbers in the potentially fatal zones (just like predicting the weather in general, supercomputers are pretty accurate at the immediate forecast numbers).

When I saw these reports, my mind was not transfixed on whether or not this was exactly accurate, or whether it was due to cremations (if so the numbers would clearly need to be hugely higher to create this phenomena), it was OMG why is the Chinese Authorities allowing huge ammounts of SO2 into the atmosphere in the midst of a pH dependant Viral outbreak?

So, immediately I went to look at the safe limits, remember the models were showing 1,300+ PPB :

  • SO2 is a toxic gas, which is directly harmful to human health. It is heavier than air and has a suffocating odour at an atmospheric concentration of around 500 parts per billion (ppb), at which level it can be fatal.  At lower levels, chest pains, breathing problems, eye irritation and a lowered resistance to heart and lung diseases can be experienced. At 20 ppb or lower there should be no ill effects to a healthy person. The normal atmospheric background concentration of SO2 is generally less than 10 ppb.
  • A secondary effect is the formation of sulphates (and nitrates), in the form of aerosols or very fine airborne particles, which can comprise a significant proportion of the particulate matter and have been linked to increased asthma attacks, heart and lung disease and respiratory problems in susceptible population groups.
  • A third effect can occur further away from the emission source where the sulphur oxides will have converted to acids by aqueous phase reactions in the atmosphere. These acidic aerosols are eventually precipitated as acid rain, snow, sleet or fog but only when they encounter the right meteorological conditions. In the absence of man made pollution rain water would be slightly acidic, around pH 5, due to the presence of carbonic acid from the interaction of water vapour and naturally occurring levels of CO2. Acid rain on the other hand has been measured with pH levels below 3 corresponding to vinegar. 
  • In their 2009 joint proposal to the IMO, the USA and Canada stated that by designating the eastern and western seaboards of North America an Emissions Control Area, as many as 8,300 lives will be saved and over three million people will experience relief from acute respiratory symptoms each year”. Reference : 4

So, we can see above, that rates at or above 500 PPB are considered an immediate threat to life, to many groups in society when all is otherwise well. However, Wuhan and several other regions are showing numbers at this level and 2-3x this level, which is a clear respiratory danger to life, whilst in the midst of another Respiratory crisis in the form of CoronaVirus.

WHAT THE HELL IS GOING ON!!!

The issue over whether this is Cremations, or not, for me is absolutely secondary (though more on this later).

The issue is, who in a sane mind in Chinese Authorities, would authorise or advise scientifically that it was fine to allow the output of huge plumes of SO2, when whole cities are in lockdown, this is INSANE!

Here is few screen grabs, I took last night to show the current predicted Air levels of Sulphur Dioxide:

Then, using https://earth.nullschool.net/ at around 12:30am 11/02/2020 UK Time, the Supercomputer forecasting modeller showed 928/2.62 = 354PPB
Wuhan area, 22 hours later at 21:00 UK Time showing 1272/2.62 = 485 ppb Near Potentially Fatal level
Chongqing region, 22 hours later at 21:00 UK Time showing 924/2.62 = 352 ppb

This is just the craziest thing I have experienced mankind do to itself ever. In the midst of cities being locked down due to a virulent Viral emergency, something in China is causing SO2 levels up to appear 1-3x that which is considered an immediate threat to life, yet we are hearing no warnings from the Chinese authorities or WHO that this is happening.

When I took these readings, multiple other cities were all showing these same high readings, Chongqing was at (or over) 500PPB and others I did not record the names of, again I stress the forecast as not running, this was a ‘prediction’ of the present.

Here is a graphic from the Wuhan Air Quality guidelines, showing the levels and targets to bring this further down, up to 2015:

So, we can see SO2 µg m3 concentrations were recorded at averaging 20µg m3 in 2015 on a downward trend line, now we are seeing 16-17x this level in the midst of a respiratory viral crisis!

As I write this today (12:45pm 11/02/2020) North West (as the wind is blowing) of Wuhan is showing readings between 300-500µg m3. It appears the out-gassing is highest during the nights, very very small mercies!

Lunchtime 11/02/2020 8:50pm Chinese Time (if burning of organic matter is happening during the night, as the modelling forecasts suggest, this may well rise back in the coming hours)

This has left me staggered, how can the Chinese Scientists who advise Government policy, or the WHO, or NATO, not be shouting and screaming about this? Imagine you are in this region, or your loved ones, and they are already at huge threat due to a clearly highly dangerous virus, then you find that the air is being degraded so much as to cause a huge uptick in susceptibility to respiratory illnesses???

It is beyond any reasonable debate, that SO2 gas is an acid forming respiratory threat, it will drive down the pH of the terrain it encounters when in sufficient volume and/or when the host lacks sufficient buffering capability.

So, now we should look at what level of SO2 output huge numbers of cremations may cause, when I was a young man I travelled around South-East Asia, one place which was fascinating was Varanasi. The ancient town famous for being a place an estimated 25,000-30,000 Hindu’s go, to be cremated in the open air Ghats per year.

If we divide the lower number 25,000 x 365 we can say an estimated 65 people per day are being Cremated in Varanasi (to my recollection I recall massively higher numbers), none-the-less, this gives us a really good baseline, to look at the SO2 levels above/around Varanasi… given this daily figure is more than are reportedly dying in any one place daily in China (or anywhere) due to CoronaVirus:

So, we can see that at 6:50pm local time in Varanasi, when the bodies will have chiefly been burning through the day, we have 12PPB = 65 bodies burned a day, straight out into the atmosphere.

So, the above shows fairly conclusively, that if it is bodies being cremated in China, the numbers must be in the range of 2 orders of magnitude higher (100x), to have anything like the outputs we are seeing in China. 650 cremations would speculatively result in 120PPB, 6,500 would conceivably result in 1,200PPB+ as has been recorded (modelled or forecast, as you will). The article on effects of SO2 cited above states that ambient levels will be below 10PPB, so we could say the difference between 10 and 12 is what 65 bodies being cremated is showing as causative, then the numbers start to spiral into much higher orders of magnitude (if a 2 points SO2 rise is shown for 65 cremations, then 65 x 20 = 130, 65 x 200 = 13,000, 1200 x 65 = 78,000!!! The numbers start to look absolutely catastrophic is this is cremation driven)

This is a crude comparison, of course, but what other way can we compare to get an insight of what might be happening to create such huge waves of seemingly deadly gas sweeping across China? Incineration of bedding, medical materials (and such) likely dampens these numbers down, but none the less, something much more dramatic than we are being shown by the Chinese authorities seems to be happening.

This is not meant to be alarmist, this is meant to be prodding around with the scant information people are discovering, to allow us to get some kind of clearer picture.

That there is a two week gestation period, before symptoms show, then if like other viruses of the type, up to an 8-10 week illness/recovery period, means we have another 4-6 weeks to see what the first wave is actually doing to people, I pray we all keep relaying the truth of our experiences, to allow the best outcome for us all.

Wishing you all well

Rich Fosh

References:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC415834/
  2. https://www.meridianinstitute.com/newslet/Vol7-3/7-3.html
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC240014/
  4. https://www.egcsa.com/technical-reference/what-are-the-effects-of-sulphur-oxides-on-human-health-and-ecosystems/
  5. https://earth.nullschool.net/
  6. https://www.windy.com/

Related :

http://chooselife.co.uk/index.php/2019/08/24/ph-the-toxicity-arrow-piercing-modern-society/

CoronaVirus pH

pH-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus Is Mediated by the Spike Glycoprotein and Enhanced by Dendritic Cell Transfer through DC-SIGN

June 2004

ABSTRACT

The severe acute respiratory syndrome coronavirus (SARS-CoV) synthesizes several putative viral envelope proteins, including the spike (S), membrane (M), and small envelope (E) glycoproteins. Although these proteins likely are essential for viral replication, their specific roles in SARS-CoV entry have not been defined. In this report, we show that the SARS-CoV S glycoprotein mediates viral entry through pH-dependent endocytosis. Further, we define its cellular tropism and demonstrate that virus transmission occurs through cell-mediated transfer by dendritic cells. The S glycoprotein was used successfully to pseudotype replication-defective retroviral and lentiviral vectors that readily infected Vero cells as well as primary pulmonary and renal epithelial cells from human, nonhuman primate, and, to a lesser extent, feline species. The tropism of this reporter virus was similar to that of wild-type, replication-competent SARS-CoV, and binding of purified S to susceptible target cells was demonstrated by flow cytometry. Although myeloid dendritic cells were able to interact with S and to bind virus, these cells could not be infected by SARS-CoV. However, these cells were able to transfer the virus to susceptible target cells through a synapse-like structure. Both cell-mediated infection and direct infection were inhibited by anti-S antisera, indicating that strategies directed toward this gene product are likely to confer a therapeutic benefit for antiviral drugs or the development of a SARS vaccine.

The severe acute respiratory syndrome coronavirus (SARS-CoV) is the likely cause of an acute infectious respiratory disorder identified in highly lethal outbreaks during the past year (1018213240). Infection is characterized by acute flu-like symptoms that progress to a severe febrile respiratory illness with significant mortality. Coronaviruses, comprising a genus of the Coronaviridae family, are enveloped positive-strand RNA viruses. In general, coronaviruses cause respiratory and enteric diseases in humans and domestic animals (1520). Two previously known human coronaviruses caused only mild upper respiratory infections (1520). In contrast, a highly pathogenic, severe respiratory disease is caused by the SARS-CoV, especially in the elderly (44). Coronaviruses can be divided into three serologically distinct groups (15). Phylogenetically, SARS-CoV is not closely related to any of the three groups (26), though it is most similar to the group II coronaviruses (3336).

Although the organization of the SARS-CoV genome is related to that of animal coronaviruses, its genetic sequence is unique, and the structure and function of its gene products are not known. At least 14 open reading frames (ORFs) can be identified in its genome (263436). Among these, the replicase/transcriptase genes are located in the 5′ portion of the genome. At its 3′ end, the four major structural proteins (S, M, N, and E) are made through different subgenomic RNAs. Based on comparison to animal coronaviruses, three structural gene products are predicted to be present on the viral envelope: the spike (S), membrane (M), and small envelope (E) proteins (202634). The structure of the SARS-CoV envelope differs in some respects from that of other enveloped viruses, such as retroviruses and lentiviruses, many of which contain one viral envelope protein.

Envelope or spike proteins from enveloped viruses have been used to pseudotype retroviral and lentiviral vectors for functional and gene transfer studies (29354345); however, whether coronavirus glycoproteins could pseudotype these viruses was unknown. Here we report that replication-defective retroviral (Moloney murine leukemia virus) and lentiviral (human immunodeficiency virus type 1 [HIV-1]) vectors can be pseudotyped with the SARS-CoV S protein, and the properties of S related to entry have been defined. Using these pseudoviruses, we were able to determine the relative contributions of SARS-CoV envelope proteins to viral entry and fusion and to examine the roles of these different viral envelope gene products with respect to entry, cell specificity, and potential inhibition of viral replication.

Pertinent Extract:

In contrast, influenza and Ebola viruses are prototypes for viruses that utilize a pH-dependent endocytotic pathway (43). To determine the pathway utilized by the SARS-CoV, the pH dependence of the SARS-CoV S-pseudotyped lentiviral vector was analyzed. Addition of ammonium chloride, which prevents acidification of the endosome, caused a dose-dependent reduction in viral entry (Fig. (Fig.1B,1B, left) at concentrations similar to those described for other pH-dependent viral glycoproteins (31143). This effect was also observed with another inhibitor of endosomal acidification, bafilomycin, also in a dose-dependent fashion (Fig. (Fig.1B,1B, right).

Full :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC415834/

Previous research from Meridian Institute Article :

Possible Relevance to SARS


    The World Health Organization has concluded that SARS is produced by a new virulent strain of coronavirus. Specific research on the possible pH dependency of the SARS virus has not yet been done.  It is well known that coronavirus infectivity is exquisitely sensitive to pH.  For example, the MHV-A59 strain of coronavirus is quite stable at pH 6.0 (acidic) but becomes rapidly and irreversibly inactivated by brief treatment at pH 8.0 (alkaline).  Human coronavirus strain 229E is maximally infective at pH 6.0.  Infection of cells by murine coronavirus A59 at pH 6.0 (acidic) rather than pH 7.0 (neutral) yields a tenfold increase in the infectivity of the virus.

  ChooseLife : If the strain of coronavirus responsible for SARS shares the pH characteristics of these other coronaviruses that are pH-dependent, this could be a valuable clue to effective prevention and treatment strategies for this potential epidemic. Perhaps keeping a balanced or slightly alkaline pH environment for the body’s tissues can provide viral protection or enhanced healing for SARS and common viral agents that cause respiratory infections. 

Inter-related to this, is research on MUC5B, which has shown that those of lower pH, are much more prone to having inhibited mucous membrane formation:

“Moreover, we demonstrate that the conformation of these highly entangled linear polymers is sensitive to calcium concentration and changes in pH. In the presence of calcium (Ca2+, 10 mM) at pH 5.0, MUC5B adopted a compact conformation which was lost either upon removal of calcium with EGTA, or by increasing the pH to 7.4. These results suggest a pathway of mucin collapse to enable intracellular packaging and mechanisms driving mucin expansion following secretion. They also point to the importance of the tight control of calcium and pH during different stages of mucin biosynthesis and secretion, and in the generation of correct mucus barrier properties.

ChooseLife Related Thoughts :

The above shows that there are multiple potential protective methodologies in play, some people may feel a glass of cold water with 1/2 teaspoon of Sodium Bicarbonate every two hours on the first day may be effective (outlined at the bottom of this page), this is one method I would consider myself (Arm and Hammer or Bobs Mill being Aluminium free). Also small Sips of highly Alkaline Milk of Magnesia, every hour, may coat the upper respiratory regions fairly well and rapidly bring up the pH, out of the greater danger zones of lower pH < 6.5 (this is my go to for my kids with sniffles or worse), I would likely do this myself for this situation.

Personally I am going to use this outbreak as a good time to bring my own (and childrens) pH up, using methods as above, plus make some Moreless Alkalising Mineral Mixture, which both Alkalises and significantly raises the Calcium levels in the body but in a complexed form (pre-bonded to Molasses or Honey) which does not hamper the Mucous membrane process outlined above, which as shown above in the scientfic literature is exactly what our bodies need to be ready to either repel, or minimise the effects of such threats.

Moreless Alkalising Mix :

http://chooselife.co.uk/index.php/2019/06/13/moreless-alkalising-remineralising-drink/

1918 Flu Prevention : Baking Soda:

https://www.proliberty.com/observer/20091216.htm

“The proven value of Bicarbonate of Soda as a therapeutic agent (from a letter to the Church and Dwight Company):

In 1918 and 1919 while fighting the Flu with the U.S. Public Health Service it was brought to my attention that rarely any one who had been thoroughly alkalinized with bicarbonate of soda contracted the disease, and those who did contract it, if alkalinized early, would invariably have mild attacks. I have since that time treated all cases of Cold, Influenza and LaGripe by first giving generous doses of Bicarbonate of Soda, and in many, many instances within 36 hours the symptoms would have entirely abated.

Further, within my own household, before Women’s Clubs and Parent-Teachers’ Association, I have advocated the use of soda as a preventative for ‘Colds’, with the result that now many reports are coming in stating that those who took ‘Soda’ were not affected, while nearly everyone around them had the ‘Flu’.

…An occasional three-day course of the Bicarbonate of Soda increases the alkalinity of the blood, assists elimination and increases the resisting power of the body to all Infectious Diseases…

Whenever taking a bicarbonate solution internally, the soda should be dissolved in cold water. In the event of a threatened attack we recommend the following treatment: During the first day take six doses of half a teaspoon of Bicarbonate of Soda in a glass of cool water, at about two hour intervals.”

General essay about pH and Toxicity:

http://chooselife.co.uk/index.php/2019/08/24/ph-the-toxicity-arrow-piercing-modern-society/

This should not be construed as Advice, simply reflections of my own thoughts.

Be Well, Rich