Open letter from medical doctors and health professionals to all Belgian authorities and all Belgian media.

September 5th 2020

We, doctors and health professionals, wish to express our serious concern about the evolution of the situation in the recent months surrounding the outbreak of the SARS-CoV-2 virus. We call on politicians to be independently and critically informed in the decision-making process and in the compulsory implementation of corona-measures. We ask for an open debate, where all experts are represented without any form of censorship. After the initial panic surrounding covid-19, the objective facts now show a completely different picture – there is no medical justification for any emergency policy anymore.
The current crisis management has become totally disproportionate and causes more damage than it does any good.
We call for an end to all measures and ask for an immediate restoration of our normal democratic governance and legal structures and of all our civil liberties.

‘A cure must not be worse than the problem’ is a thesis that is more relevant than ever in the current situation. We note, however, that the collateral damage now being caused to the population will have a greater impact in the short and long term on all sections of the population than the number of people now being safeguarded from corona.
In our opinion, the current corona measures and the strict penalties for non-compliance with them are contrary to the values formulated by the Belgian Supreme Health Council, which, until recently, as the health authority, has always ensured quality medicine in our country: “Science – Expertise – Quality – Impartiality – Independence – Transparency”. 1

We believe that the policy has introduced mandatory measures that are not sufficiently scientifically based, unilaterally directed, and that there is not enough space in the media for an open debate in which different views and opinions are heard. In addition, each municipality and province now has the authorisation to add its own measures, whether well-founded or not.

Moreover, the strict repressive policy on corona strongly contrasts with the government’s minimal policy when it comes to disease prevention, strengthening our own immune system through a healthy lifestyle, optimal care with attention for the individual and investment in care personnel.2

The concept of health

In 1948, the WHO defined health as follows: ‘Health is a state of complete physical, mental and social well-being and not merely the absence of disease or other physical impairment’.3

Health, therefore, is a broad concept that goes beyond the physical and also relates to the emotional and social well-being of the individual. Belgium also has a duty, from the point of view of subscribing to fundamental human rights, to include these human rights in its decision-making when it comes to measures taken in the context of public health. 4
The current global measures taken to combat SARS-CoV-2 violate to a large extent this view of health and human rights. Measures include compulsory wearing of a mask (also in open air and during sporting activities, and in some municipalities even when there are no other people in the vicinity), physical distancing, social isolation, compulsory quarantine for some groups and hygiene measures.

The predicted pandemic with millions of deaths

At the beginning of the pandemic, the measures were understandable and widely supported, even if there were differences in implementation in the countries around us. The WHO originally reported in March that the death rate among the registered covid-19 cases was 3.4%. Millions of deaths were thus foreseen, and an extremely contagious virus for which no treatment or vaccine was available.  This would put unprecedented pressure on the intensive care units (ICUs) of our hospitals.

This led to a global alarm situation, never seen in the history of mankind: “flatten the curve” was represented by a lockdown that shut down the entire society and economy and quarantined healthy people. Social distancing became the new normal in anticipation of a rescue vaccine.

The facts about covid-19

Gradually, the alarm bell was sounded from many sources: the objective facts showed a completely different reality. 5 6

The course of covid-19 followed the course of a normal wave of infection similar to a flu season. As every year, we see a mix of flu viruses following the curve: first the rhinoviruses, then the influenza A and B viruses, followed by the coronaviruses. There is nothing different from what we normally see.

The use of the non-specific PCR test, which produces many false positives, showed an exponential picture.  This test was rushed through with an emergency procedure and was never seriously self-tested. The creator expressly warned that this test was intended for research and not for diagnostics.7
The PCR test works with cycles of amplification of genetic material – a piece of genome is amplified each time. Any contamination (e.g. other viruses, debris from old virus genomes) can possibly result in false positives.8

The test does not measure how many viruses are present in the sample. A real viral infection means a massive presence of viruses, the so-called virus load. If someone tests positive, this does not mean that that person is actually clinically infected, is ill or is going to become ill. Koch’s postulate was not fulfilled (“The pure agent found in a patient with complaints can provoke the same complaints in a healthy person”).

Since a positive PCR test does not automatically indicate active infection or infectivity, this does not justify the social measures taken, which are based solely on these tests. 9 10

Lockdown.

If we compare the waves of infection in countries with strict lockdown policies to countries that did not impose lockdowns (Sweden, Iceland …), we see similar curves.  So there is no link between the imposed lockdown and the course of the infection. Lockdown has not led to a lower mortality rate.

If we look at the date of application of the imposed lockdowns we see that the lockdowns were set after the peak of the virus replication rate was already over and decreasing. The drop was therefore not the result of the taken measures. 11
As every year, it seems that climatic conditions (weather, temperature and humidity) and growing immunity are more likely to reduce the wave of infection.

Our immune system

For thousands of years, the human body has been exposed daily to moisture and droplets containing infectious microorganisms (viruses, bacteria and fungi).

The penetration of these microorganisms is prevented by an advanced defence mechanism – the immune system. A strong immune system relies on normal daily exposure to these microbial influences. Overly hygienic measures have a detrimental effect on our immunity. 12 13 Only people with a weak or faulty immune system should be protected by extensive hygiene or social distancing.

Influenza will re-emerge in the autumn (in combination with covid-19) and a possible decrease in natural resilience may lead to further casualties.

Our immune system consists of two parts: a congenital, non-specific immune system and an adaptive immune system.

The non-specific immune system forms a first barrier: skin, saliva, gastric juice, intestinal mucus, vibratory hair cells, commensal flora, … and prevents the attachment of micro-organisms to tissue.

If they do attach, macrophages can cause the microorganisms to be encapsulated and destroyed.

The adaptive immune system consists of mucosal immunity (IgA antibodies, mainly produced by cells in the intestines and lung epithelium), cellular immunity (T-cell activation), which can be generated in contact with foreign substances or microorganisms, and humoral immunity (IgM and IgG antibodies produced by the B cells).

Recent research shows that both systems are highly entangled.

It appears that most people already have a congenital or general immunity to e.g. influenza and other viruses. This is confirmed by the findings on the cruise ship Diamond Princess, which was quarantined because of a few passengers who died of Covid-19. Most of the passengers were elderly and were in an ideal situation of transmission on the ship. However, 75% did not appear to be infected. So even in this high-risk group, the majority are resistant to the virus.

A study in the journal Cell shows that most people neutralise the coronavirus by mucosal (IgA) and cellular immunity (T-cells), while experiencing few or no symptoms 14.

Researchers found up to 60% SARS-Cov-2 reactivity with CD4+T cells in a non-infected population, suggesting cross-reactivity with other cold (corona) viruses.15

Most people therefore already have a congenital or cross-immunity because they were already in contact with variants of the same virus.

The antibody formation (IgM and IgG) by B-cells only occupies a relatively small part of our immune system. This may explain why, with an antibody percentage of 5-10%, there may be a group immunity anyway. The efficacy of vaccines is assessed precisely on the basis of whether or not we have these antibodies. This is a misrepresentation.

Most people who test positive (PCR) have no complaints. Their immune system is strong enough. Strengthening natural immunity is a much more logical approach. Prevention is an important, insufficiently highlighted pillar: healthy, full-fledged nutrition, exercise in fresh air, without a mask, stress reduction and nourishing emotional and social contacts.

Consequences of social isolation on physical and mental health

Social isolation and economic damage led to an increase in depression, anxiety, suicides, intra-family violence and child abuse.16

Studies have shown that the more social and emotional commitments people have, the more resistant they are to viruses. It is much more likely that isolation and quarantine have fatal consequences. 17

The isolation measures have also led to physical inactivity in many older people due to their being forced to stay indoors. However, sufficient exercise has a positive effect on cognitive functioning, reducing depressive complaints and anxiety and improving physical health, energy levels, well-being and, in general, quality of life.18

Fear, persistent stress and loneliness induced by social distancing have a proven negative influence on psychological and general health. 19

A highly contagious virus with millions of deaths without any treatment?

Mortality turned out to be many times lower than expected and close to that of a normal seasonal flu (0.1-0.5%). 20
The number of registered corona deaths therefore still seems to be overestimated.
There is a difference between death by corona and death with corona. Humans are often carriers of multiple viruses and potentially pathogenic bacteria at the same time. Taking into account the fact that most people who developed serious symptoms suffered from additional pathology, one cannot simply conclude that the corona-infection was the cause of death. This was mostly not taken into account in the statistics.

The most vulnerable groups can be clearly identified. The vast majority of deceased patients were 80 years of age or older. The majority (70%) of the deceased, younger than 70 years, had an underlying disorder, such as cardiovascular suffering, diabetes mellitus, chronic lung disease or obesity. The vast majority of infected persons (>98%) did not or hardly became ill or recovered spontaneously.

Meanwhile, there is an affordable, safe and efficient therapy available for those who do show severe symptoms of disease in the form of HCQ (hydroxychloroquine), zinc and azithromycin. Rapidly applied this therapy leads to recovery and often prevents hospitalisation. Hardly anyone has to die now.

This effective therapy has been confirmed by the clinical experience of colleagues in the field with impressive results. This contrasts sharply with the theoretical criticism (insufficient substantiation by double-blind studies) which in some countries (e.g. the Netherlands) has even led to a ban on this therapy. A meta-analysis in The Lancet, which could not demonstrate an effect of HCQ, was withdrawn. The primary data sources used proved to be unreliable and 2 out of 3 authors were in conflict of interest. However, most of the guidelines based on this study remained unchanged … 48 49
We have serious questions about this state of affairs.
In the US, a group of doctors in the field, who see patients on a daily basis, united in “America’s Frontline Doctors” and gave a press conference which has been watched millions of times.21 51
French Prof Didier Raoult of the Institut d’Infectiologie de Marseille (IHU) also presented this promising combination therapy as early as April. Dutch GP Rob Elens, who cured many patients in his practice with HCQ and zinc, called on colleagues in a petition for freedom of therapy.22
The definitive evidence comes from the epidemiological follow-up in Switzerland: mortality rates compared with and without this therapy.23

From the distressing media images of ARDS (acute respiratory distress syndrome) where people were suffocating and given artificial respiration in agony, we now know that this was caused by an exaggerated immune response with intravascular coagulation in the pulmonary blood vessels. The administration of blood thinners and dexamethasone and the avoidance of artificial ventilation, which was found to cause additional damage to lung tissue, means that this dreaded complication, too, is virtually not fatal anymore. 47

It is therefore not a killer virus, but a well-treatable condition.

Propagation

Spreading occurs by drip infection (only for patients who cough or sneeze) and aerosols in closed, unventilated rooms. Contamination is therefore not possible in the open air. Contact tracing and epidemiological studies show that healthy people (or positively tested asymptomatic carriers) are virtually unable to transmit the virus. Healthy people therefore do not put each other at risk. 24 25
Transfer via objects (e.g. money, shopping or shopping trolleys) has not been scientifically proven.26 27 28

All this seriously calls into question the whole policy of social distancing and compulsory mouth masks for healthy people – there is no scientific basis for this.

Masks

Oral masks belong in contexts where contacts with proven at-risk groups or people with upper respiratory complaints take place, and in a medical context/hospital-retirement home setting. They reduce the risk of droplet infection by sneezing or coughing. Oral masks in healthy individuals are ineffective against the spread of viral infections. 29 30 31

Wearing a mask is not without side effects. 32 33 Oxygen deficiency (headache, nausea, fatigue, loss of concentration) occurs fairly quickly, an effect similar to altitude sickness. Every day we now see patients complaining of headaches, sinus problems, respiratory problems and hyperventilation due to wearing masks. In addition, the accumulated CO2 leads to a toxic acidification of the organism which affects our immunity. Some experts even warn of an increased transmission of the virus in case of inappropriate use of the mask.34

Our Labour Code (Codex 6) refers to a CO2 content (ventilation in workplaces) of 900 ppm, maximum 1200 ppm in special circumstances. After wearing a mask for one minute, this toxic limit is considerably exceeded to values that are three to four times higher than these maximum values. Anyone who wears a mask is therefore in an extreme poorly ventilated room. 35

Inappropriate use of masks without a comprehensive medical cardio-pulmonary test file is therefore not recommended by recognised safety specialists for workers.
Hospitals have a sterile environment in their operating rooms where staff wear masks and there is precise regulation of humidity / temperature with appropriately monitored oxygen flow to compensate for this, thus meeting strict safety standards. 36

A second corona wave?

A second wave is now being discussed in Belgium, with a further tightening of the measures as a result. However, closer examination of Sciensano’s figures37 shows that, although there has been an increase in the number of infections since mid-July, there was no increase in hospital admissions or deaths at that time. It is therefore not a second wave of corona, but a so-called “case chemistry” due to an increased number of tests. 50
The number of hospital admissions or deaths showed a shortlasting minimal increase in recent weeks, but in interpreting it, we must take into account the recent heatwave. In addition, the vast majority of the victims are still in the population group >75 years.
This indicates that the proportion of the measures taken in relation to the working population and young people is disproportionate to the intended objectives.
The vast majority of the positively tested “infected” persons are in the age group of the active population, which does not develop any or merely limited symptoms, due to a well-functioning immune system.
So nothing has changed – the peak is over.

Strengthening a prevention policy

The corona measures form a striking contrast to the minimal policy pursued by the government until now, when it comes to well-founded measures with proven health benefits such as the sugar tax, the ban on (e-)cigarettes and making healthy food, exercise and social support networks financially attractive and widely accessible. It is a missed opportunity for a better prevention policy that could have brought about a change in mentality in all sections of the population with clear results in terms of public health. At present, only 3% of the health care budget goes to prevention. 2

The Hippocratic Oath

As a doctor, we took the Hippocratic Oath:
“I will above all care for my patients, promote their health and alleviate their suffering”.

“I will inform my patients correctly.”

“Even under pressure, I will not use my medical knowledge for practices that are against humanity.”
The current measures force us to act against this oath.
Other health professionals have a similar code.

The ‘primum non nocere’, which every doctor and health professional assumes, is also undermined by the current measures and by the prospect of the possible introduction of a generalised vaccine, which is not subject to extensive prior testing.

Vaccine

Survey studies on influenza vaccinations show that in 10 years we have only succeeded three times in developing a vaccine with an efficiency rate of more than 50%. Vaccinating our elderly appears to be inefficient. Over 75 years of age, the efficacy is almost non-existent.38
Due to the continuous natural mutation of viruses, as we also see every year in the case of the influenza virus, a vaccine is at most a temporary solution, which requires new vaccines each time afterwards. An untested vaccine, which is implemented by emergency procedure and for which the manufacturers have already obtained legal immunity from possible harm, raises serious questions. 39 40 We do not wish to use our patients as guinea pigs.
On a global scale, 700 000 cases of damage or death are expected as a result of the vaccine.41
If 95% of people experience Covid-19 virtually symptom-free, the risk of exposure to an untested vaccine is irresponsible.

The role of the media and the official communication plan

Over the past few months, newspaper, radio and TV makers seemed to stand almost uncritically behind the panel of experts and the government, there, where it is precisely the press that should be critical and prevent one-sided governmental communication. This has led to a public communication in our news media, that was more like propaganda than objective reporting.

In our opinion, it is the task of journalism to bring news as objectively and neutrally as possible, aimed at finding the truth and critically controlling power, with dissenting experts also being given a forum in which to express themselves.

This view is supported by the journalistic codes of ethics.42

The official story that a lockdown was necessary, that this was the only possible solution, and that everyone stood behind this lockdown, made it difficult for people with a different view, as well as experts, to express a different opinion.

Alternative opinions were ignored or ridiculed. We have not seen open debates in the media, where different views could be expressed.

We were also surprised by the many videos and articles by many scientific experts and authorities, which were and are still being removed from social media. We feel that this does not fit in with a free, democratic constitutional state, all the more so as it leads to tunnel vision. This policy also has a paralysing effect and feeds fear and concern in society. In this context, we reject the intention of censorship of dissidents in the European Union! 43

The way in which Covid-19 has been portrayed by politicians and the media has not done the situation any good either. War terms were popular and warlike language was not lacking. There has often been mention of a ‘war’ with an ‘invisible enemy’ who has to be ‘defeated’. The use in the media of phrases such as ‘care heroes in the front line’ and ‘corona victims’ has further fuelled fear, as has the idea that we are globally dealing with a ‘killer virus’.

The relentless bombardment with figures, that were unleashed on the population day after day, hour after hour, without interpreting those figures, without comparing them to flu deaths in other years, without comparing them to deaths from other causes, has induced a real psychosis of fear in the population. This is not information, this is manipulation.

We deplore the role of the WHO in this, which has called for the infodemic (i.e. all divergent opinions from the official discourse, including by experts with different views) to be silenced by an unprecedented media censorship.43 44

We urgently call on the media to take their responsibilities here!

We demand an open debate in which all experts are heard.

Emergency law versus Human Rights

The general principle of good governance calls for the proportionality of government decisions to be weighed up in the light of the Higher Legal Standards: any interference by government must comply with the fundamental rights as protected in the European Convention on Human Rights (ECHR). Interference by public authorities is only permitted in crisis situations. In other words, discretionary decisions must be proportionate to an absolute necessity.

The measures currently taken concern interference in the exercise of, among other things, the right to respect of private and family life, freedom of thought, conscience and religion, freedom of expression and freedom of assembly and association, the right to education, etc., and must therefore comply with fundamental rights as protected by the European Convention on Human Rights (ECHR).
For example, in accordance with Article 8(2) of the ECHR, interference with the right to private and family life is permissible only if the measures are necessary in the interests of national security, public safety, the economic well-being of the country, the protection of public order and the prevention of criminal offences, the protection of health or the protection of the rights and freedoms of others, the regulatory text on which the interference is based must be sufficiently clear, foreseeable and proportionate to the objectives pursued.45

The predicted pandemic of millions of deaths seemed to respond to these crisis conditions, leading to the establishment of an emergency government. Now that the objective facts show something completely different, the condition of inability to act otherwise (no time to evaluate thoroughly if there is an emergency) is no longer in place. Covid-19 is not a killervirus, but a well treatable condition with a mortality rate comparable to the seasonal flu. In other words, there is no longer an insurmountable obstacle to public health.

There is no state of emergency.

Immense damage caused by the current policies

An open discussion on corona measures means that, in addition to the years of life gained by corona patients, we must also take into account other factors affecting the health of the entire population. These include damage in the psychosocial domain (increase in depression, anxiety, suicides, intra-family violence and child abuse)16 and economic damage.

If we take this collateral damage into account, the current policy is out of all proportion, the proverbial use of a sledgehammer to crack a nut.

We find it shocking that the government is invoking health as a reason for the emergency law.

As doctors and health professionals, in the face of a virus which, in terms of its harmfulness, mortality and transmissibility, approaches the seasonal influenza, we can only reject these extremely disproportionate measures.

  • We therefore demand an immediate end to all measures.
  • We are questioning the legitimacy of the current advisory experts, who meet behind closed doors.
  • Following on from ACU 2020 46 https://acu2020.org/nederlandse-versie/ we call for an in-depth examination of the role of the WHO and the possible influence of conflicts of interest in this organisation. It was also at the heart of the fight against the “infodemic”, i.e. the systematic censorship of all dissenting opinions in the media. This is unacceptable for a democratic state governed by the rule of law.43

Distribution of this letter

We would like to make a public appeal to our professional associations and fellow carers to give their opinion on the current measures.

We draw attention to and call for an open discussion in which carers can and dare to speak out.

With this open letter, we send out the signal that progress on the same footing does more harm than good, and call on politicians to inform themselves independently and critically about the available evidence – including that from experts with different views, as long as it is based on sound science – when rolling out a policy, with the aim of promoting optimum health.

This letter was originally intended for Belgian doctors and health professionals/Belgian citizens.

More and more foreign colleagues reacted as well and wanted to sign the open letter. The objectively substantiated facts and our demand for an immediate end to all further measures appear to have crossed all borders. We decided therefore at one point to definitively open the letter to all doctors – anywhere in the world – who agree with its content.

This way, the open letter becomes an internationally supported document that aims to openly expose the fake pandemic, which is being perpetuated by the media and governments all over the world.With concern, hope and in a personal capacity.

  1. https://www.health.belgium.be/nl/wie-zijn-we#Missie
  2. standaard.be/preventie
  3. https://www.who.int/about/who-we-are/constitution
  4. https://www.who.int/news-room/fact-sheets/detail/human-rights-and-health
  5. https://swprs.org/feiten-over-covid19/
  6. https://the-iceberg.net/
  7. https://www.creative-diagnostics.com/sars-cov-2-coronavirus-multiplex-rt-qpcr-kit-277854-457.htm
  8. President John Magufuli of Tanzania: “Even Papaya and Goats are Corona positive” https://www.youtube.com/watch?v=207HuOxltvI
  9. Open letter by biochemist Drs Mario Ortiz Martinez to the Dutch chamber https://www.gentechvrij.nl/2020/08/15/foute-interpretatie/
  10. Interview with Drs Mario Ortiz Martinez https://troo.tube/videos/watch/6ed900eb-7459-4a1b-93fd-b393069f4fcd?fbclid=IwAR1XrullC2qopJjgFxEgbSTBvh-4ZCuJa1VxkHTXEtYMEyGG3DsNwUdaatY
  11. https://infekt.ch/2020/04/sind-wir-tatsaechlich-im-blindflug/
  12. Lambrecht, B., Hammad, H. The immunology of the allergy epidemic and the hygiene hypothesis. Nat Immunol 18, 1076–1083 (2017). https://www.nature.com/articles/ni.3829
  13. Sharvan Sehrawat, Barry T. Rouse, Does the hygiene hypothesis apply to COVID-19 susceptibility?, Microbes and Infection, 2020, ISSN 1286-4579, https://doi.org/10.1016/j.micinf.2020.07.002
  14. https://www.cell.com/cell/fulltext/S0092-8674(20)30610-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420306103%3Fshowall%3Dtrue
  15. https://www.hpdetijd.nl/2020-08-11/9-manieren-om-corona-te-voorkomen/
  16. Feys, F., Brokken, S., & De Peuter, S. (2020, May 22). Risk-benefit and cost-utility analysis for COVID-19 lockdown in Belgium: the impact on mental health and wellbeing. https://psyarxiv.com/xczb3/
  17. Kompanje, 2020
  18. Conn, Hafdahl en Brown, 2009; Martinsen 2008; Yau, 2008
  19. https://brandbriefggz.nl/
  20. https://swprs.org/studies-on-covid-19-lethality/#overall-mortality
  21. https://www.xandernieuws.net/algemeen/groep-artsen-vs-komt-in-verzet-facebook-bant-hun-17-miljoen-keer-bekeken-video/
  22. https://www.petities.com/einde_corona_crises_overheid_sta_behandeling_van_covid-19_met_hcq_en_zink_toe
  23. https://zelfzorgcovid19.nl/statistieken-zwitserland-met-hcq-zonder-hcq-met-hcq-leveren-het-bewijs/
  24. https://www.cnbc.com/2020/06/08/asymptomatic-coronavirus-patients-arent-spreading-new-infections-who-says.html
  25. http://www.emro.who.int/health-topics/corona-virus/transmission-of-covid-19-by-asymptomatic-cases.html
  26. WHO https://www.marketwatch.com/story/who-we-did-not-say-that-cash-was-transmitting-coronavirus-2020-03-06
  27. https://www.nordkurier.de/ratgeber/es-gibt-keine-gefahr-jemandem-beim-einkaufen-zu-infizieren-0238940804.html
  28. https://www.reuters.com/article/us-health-coronavirus-germany-banknotes/banknotes-carry-no-particular-coronavirus-risk-german-disease-expert-idUSKBN20Y2ZT
  29. 29. Contradictory statements by our virologists https://www.youtube.com/watch?v=6K9xfmkMsvM
  30. https://www.hpdetijd.nl/2020-07-05/stop-met-anderhalve-meter-afstand-en-het-verplicht-dragen-van-mondkapjes/
  31. Security expert Tammy K. Herrema Clark https://youtu.be/TgDm_maAglM
  32. https://theplantstrongclub.org/2020/07/04/healthy-people-should-not-wear-face-masks-by-jim-meehan-md/
  33. https://www.technocracy.news/blaylock-face-masks-pose-serious-risks-to-the-healthy/
  34. https://www.news-medical.net/news/20200315/Reusing-masks-may-increase-your-risk-of-coronavirus-infection-expert-says.aspx
  35. https://werk.belgie.be/nl/nieuws/nieuwe-regels-voor-de-kwaliteit-van-de-binnenlucht-werklokalen
  36. https://kavlaanderen.blogspot.com/2020/07/als-maskers-niet-werken-waarom-dragen.html
  37. https://covid-19.sciensano.be/sites/default/files/Covid19/Meest%20recente%20update.pdf
  38. Haralambieva, I.H. et al., 2015. The impact of immunosenescence on humoral immune response variation after influenza A/H1N1 vaccination in older subjects. https://pubmed.ncbi.nlm.nih.gov/26044074/
  39. Global vaccine safety summit WHO 2019 https://www.youtube.com/watch?v=oJXXDLGKmPg
  40. No liability manufacturers vaccines https://m.nieuwsblad.be/cnt/dmf20200804_95956456?fbclid=IwAR0IgiA-6sNVQvE8rMC6O5Gq5xhOulbcN1BhdI7Rw-7eq_pRtJDCxde6SQI
  41. https://www.newsbreak.com/news/1572921830018/bill-gates-admits-700000-people-will-be-harmed-or-killed-by-his-covid-19-solution
  42. Journalistic code https://www.rvdj.be/node/63
  43. Disinformation related to COVID-19 approaches European Commission EurLex, juni 2020 (this file will not damage your computer)
  44. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30461-X/fulltext
  45. http://www.raadvst-consetat.be/dbx/adviezen/67142.pdf#search=67.142
  46. https://acu2020.org/
  47. https://reader.elsevier.com/reader/sd/pii/S0049384820303297?token=9718E5413AACDE0D14A3A0A56A89A3EF744B5A201097F4459AE565EA5EDB222803FF46D7C6CD3419652A215FDD2C874F
  48. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31180-6/fulltext
  49. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31324-6/fulltext
  50. There is no revival of the pandemic, but a so-called casedemic due to more testing.
    https://www.greenmedinfo.com/blog/crucial-viewing-understanding-covid-19-casedemic1
  51. https://docs4opendebate.be/wp-content/uploads/2020/09/white-paper-on-hcq-from-AFD.pdf

At time of posting :

Signed by 599 medical doctors
Signed by 1882 medically trained health professionals

COVID-19-Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches

Authors : Alexander V SorokinSotirios K KarathanasisZhi-Hong YangLita FreemanKazuhiko KotaniAlan T Remaley

Abstract

The current coronavirus disease 2019 (COVID-19) pandemic presents a global challenge for managing acutely ill patients and complications from viral infection. Systemic inflammation accompanied by a “cytokine storm,” hemostasis alterations and severe vasculitis have all been reported to occur with COVID-19, and emerging evidence suggests that dysregulation of lipid transport may contribute to some of these complications. Here, we aim to summarize the current understanding of the potential mechanisms related to COVID-19 dyslipidemia and propose possible adjunctive type therapeutic approaches that modulate lipids and lipoproteins. Specifically, we hypothesize that changes in the quantity and composition of high-density lipoprotein (HDL) that occurs with COVID-19 can significantly decrease the anti-inflammatory and anti-oxidative functions of HDL and could contribute to pulmonary inflammation. Furthermore, we propose that lipoproteins with oxidized phospholipids and fatty acids could lead to virus-associated organ damage via overactivation of innate immune scavenger receptors. Restoring lipoprotein function with ApoA-I raising agents or blocking relevant scavenger receptors with neutralizing antibodies could, therefore, be of value in the treatment of COVID-19. Finally, we discuss the role of omega-3 fatty acids transported by lipoproteins in generating specialized proresolving mediators and how together with anti-inflammatory drugs, they could decrease inflammation and thrombotic complications associated with COVID-19.

Keywords: COVID-19; dyslipidemia; inflammation; lipoproteins; oxidation.

Full Article : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361619/

5G Technology and induction of coronavirus in skin cells

JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS

Vol. 34, no. 4, xx-xx (2020) – Received May 13, 2020 – Accepted June 9, 2020

M. Fioranelli¹, A. Sepehri¹, M.G. Roccia¹,
M. Jafferany²,
O. Yu. Olisova³, K.M. Lomonosov³ and T. Lotti¹,³
¹Department of Nuclear, Sub-nuclear and Radiation Physics, G. MarconiUniversity, Rome, Italy;
²Central Michigan Saginaw, Michigan , USA; 
³Department of Dermatology and Venereology, I.M.Sechenov First Moscow State Medical University, Moscow, Russia

In this research, we show that 5G millimeter waves could be absorbed by dermatologic cells acting like antennas, transferred to other cells and play the main role in producing Coronaviruses in biological cells. DNA is built from charged electrons and atoms and has an inductor-like structure. This structure could be divided into linear, toroid and round inductors. Inductors interact with external electromagnetic waves, move and produce some extra waves within the cells. The shapes of these waves are similar to shapes of hexagonal and pentagonal bases of their DNA source. These waves produce some holes in liquids within the nucleus. To fill these holes, some extra hexagonal andpentagonal bases are produced. These bases could join to each other and form virus-like structures such as Coronavirus. To produce these viruses within a cell, it is necessary that the wavelength of external waves be shorter than the size of the cell. Thus 5G millimeter waves could be good candidates for applying in constructing virus-like structures such as Coronaviruses (COVID-19) within cells.

Coronavirus disease (COVID-19) is the main problem this year involving the entire world (1). This is an infectious disease caused by a newly-discovered coronavirus. This virus is a member of related viruses that cause diseases in mammals and birds. In humans, coronaviruses cause respiratory tract infections that can be mild, such as some cases of the common cold (among other possible causes, predominantly rhinoviruses), and others that can be lethal, such as SARS, MERS, and COVID-19. Among them, COVID-19 is an enveloped virus with a positive-sense single-stranded RNA genome and anucleocapsid of helical symmetry. The genome size of coronaviruses ranges from approximately 27 to 34 kilo bases, the largest among known RNA viruses (2, 3).

To date, many scientists have tried to find a method to cure this disease (4, 5); however, without success. COVID-19 may have effects on different types of cells. For example, it has been argued that this virus may have some effects on dermatologic cells (6). On the other hand, it has been known that some waves in 5G technology have direct effects on the skin cells (7). Thus, there are some similarities between effects of COVID-19 and waves in 5G technology.

A new question arises regarding a relationship between 5G technology and COVID-19. The 5G technology is the fifth-generation mobile technology in which its frequency spectrum could be divided into millimeter waves, mid-band, and low-band. Low- band uses a similar frequency range as the predecessor, 4G. 5G millimeter wave is the fastest, with actual speeds often being 1–2 Gbit/s down. Its frequencies are above 24 GHz, reaching up to 72 GHz, which is above the extremely high frequency band’s lower boundary. Millimeter waves have shorter range than microwaves, therefore the reactive cells are those with smaller size (8-10). Consequently, biological cells also could act like a receiver for these waves. Many researchers have considered the effects of 5G technology on human health. For example, it has been shown that 5G mobile networking technology will affect not only the skin and eyes, but will have adverse systemic effects as well (11). In another study, it was argued that 5G technologies cause great harm to human health. Cancer is only one of the many problems. 5G causes 720 (factorial) different diseases in human beings, and can kill everything that lives except some forms of microorganisms (12). To consider the effects of 5G millimeter waves on biological systems, we propose a model which describes the process of exchanging waves between 5G towers and host cells.

To date, some researchers have tried to propose a model for using waves in extracting information within cells (13, 14). These waves could be transverse electromagnetic fields or longitudinal ultrasound waves. A DNA is built from charged particles and according to laws of physics, by any motion of these particles, some electromagnetic waves emerge(15). Also, the structure of a DNA is similar to the structure of an inductor (16) in a receiver and can produce some waves. Thus, a DNA could emit some waves and interact with external waves. However, most waves have a length more than the size of cells and pass them without any effect. Only limited waves with lengths smaller than millimeter could penetrate into cell membrane and interact with DNA inductors. These wavelengths could be observed in 5G technology. Thus, towers in this technology could exchange waves with DNAs within cells and produce various types of diseases such as COVID-19. In this study, we propose a mechanism for exchanged waves between towers and host cells to obtain effective wavelengths. In our method, skin cells act as dermatologic antenna, take waves in 5G technology and transfer them to host cells. Then, DNAs within host cells interact with these waves and move. By motions of a DNA, some hexagonal and pentagonal holes emerge. To fill these holes,some bases are constructed within cells. These holes join to each other and form RNAs of COVID-19.

MATERIALS AND METHODS

A mechanism for exchanging waves between towers and dermatologic cells in 5G technology.

Skin cells are in close connections with nerve fibers. These fibers in the nervous system play the role of wires which carry some electrical currents; these currents produce some electromagnetic waves. These waves and currents are taken by melanocytes, keratinocytes and other dermatologic cells and transmitted to the medium. On the other hand, skin cells could take waves of towers and transfer to other cells and neurons. Thus, dermatologic cells could act as an antenna (Fig. 1).

An antenna could take waves in which their wavelengths are equal to its size. Thus, millimeter waves in 5G technology could be taken more by dermatologic antennas. These waves could pass the cell membranes,enter the nucleus and interact with DNAs. Previously, it has been shown that a DNA could act as the inductor and receiver or sender of waves (16). Thus, a DNA within a dermatologic cell like a keratinocyte receives external waves and sends them to DNAs of other cells like melanocytes. Waves in 5G technology and higher technologies could contribute in gene expressions, turn on some genes and turn off others (Fig. 2).

The question is whether millimeter waves in 5G technology could contribute in constructing some viruses like COVID-19 within a cell. To reply to this question, we should consider the electronic structure of a DNA and its emitted waves. A DNA is built from atoms and electrons. These particles have some electrical charges and emit electrical fields. Also, by each motion of a DNA, its atoms and electrons move. According to the laws of physics, by motion of charged particles, some magnetic waves emerge. Consequently, a DNA emits both electrical and magnetic fields and plays the role of electrical devices within a cell. The structure of a DNA within a cell is similar to the structure of an inductor. When a DNA coils around a nucleosome, it takes the shape of a toroid inductor. Also, by coiling around another axes, a DNA becomes very similar to round inductors (Fig. 3).

Fig. 1. Some waves in 5G technology could be taken by dermatologic antennas, however radio waves could not pass the skin cells

Fig. 2. Waves in 5G technology pass the cell membranes and contribute to gene expressions

Fig. 3. A similarity between different states of DNA with different types of inductors

A DNA coils several times around different axes within chromosomes and produces different types of inductors and electronic devices. Thus, any state of a DNA is similar to a type of an inductor and emits a special wave. Some of these waves are linear, some are curved and others have toroidal shapes (Fig. 4).

A DNA, as an electronic device within a cell, could exchange waves with medium, especially when an electromagnetic wave passes the cell membrane and the nuclear membrane, it induces an extra magnetic field within the DNA inductor and interacts with its fields. This interaction causes extra motions of this DNA, and through the motion of this DNA, its charges move and emit electromagnetic waves. The wavelength of emitted waves from a DNA is equal or less than its size within a cell. Also, shapes of radiated waves by a DNA have direct relations with the shapes of their genetic source. A DNA is formed from hexagonal and pentagonal manifolds; thus,its emitted waves have hexagonal and pentagonal shapes. These waves produce hexagonal and pentagonal holes within the liquids of a nucleus and a cell. To fill these holes, hexagonal and pentagonal molecules are built. These extra hexagonal and pentagonal bases may join to each other and form structures like RNAs of COVID-19 viruses. To produce these viruses, it is necessary that the wave lengths of external electromagnetic fields be equal or less than the size of a cell. For this reason, 5G technology waves could have the main role in the emergence of COVID-19, however radio waves could not have any effect on the evolutions within a cell (Fig. 5).


RESULTS

Effective wavelengths within a cell in 5G technology We propose a model to obtain a probability for the amount of effects of external fields on the evolutions of cells within a cell. This probability is related to the number of micro states of a DNA within a cell:PDNA = ΩDNA, EM / ΩDNA, tot (1)

Where ΩDNA is the probability, ΩDNA, EM is the number of micro states which are produced by the interaction between DNAs and electromagnetic waves, and ΩDNA, tot is the total number of micro states. These micro states have direct relations with entropies:

SDNA = KS LOG (ΩDNA, EM) (2)

Where SDNA is the entropy and KS is a constant. On the other hand, entropies have direct relations with energies:

SDNA =EDNA / Tcell (3)

Where EDNA is the excited energy of a DNA and Tcell is the temperature within a cell. Excited energy of a DNA depends on the linear and curved energies of hexagonal and pentagonal bases:

EDNA = UB, linear,5 V B, linear,5 + UB, curved,5 V B, curved,5 + UB, supercoil,5 V B, supercoil,5 + UB, linear,6 V B, linear,6 + UB, curved,6 V B, curved,6 + UB, supercoil,6 V B, supercoil,6 (4)

Fig. 4. A DNA within the nucleus acts as the inductor and emits magnetic waves

Where UB, linear,5/6 is the energy density of a pentagonal/hexagonal molecule, V B, linear, ,5/6 is the volume of a pentagonal/hexagonal disk , UB, curved, ,5/6 is the energy density of a pentagonal/hexagonal molecule which coils around a nucleosome, V B, curved, ,5/6 is the volume of a coiled pentagonal/hexagonal
disk, UB, supercoil, ,5/6 is the energy density of a pentagonal/hexagonal molecule which coils around supercoil axes and V B, supercoil, ,5/6 is its volume. Volumes can be obtained from the following equations:

V B, linear,5 = 5 [1/2 (rbase + xEM )2 cos (ϴpenta)sin(ϴpenta)][ rbase + xEM]
V B, linear,6 = 5 [1/2 (rbase + xEM )2 cos (ϴhexa)sin(ϴhexa)] [ rbase + xEM]
V B, curved,5 = 5π [1/2 (rbase + xEM )2 cos (ϴpenta) sin(ϴpenta)]×
[ rbase + xEM][ rhistone + xEM]2 V B, curved,6 = 5π [1/2 (rbase + xEM )2 cos (ϴhexa)sin(ϴhexa)] )]× [ rbase + xEM][ rhistone + xEM]2
V B, supercoil,5 = 5π2 [1/2 (rbase + xEM )2 cos (ϴpenta) sin(ϴpenta)]× [ rbase + xEM][ rhistone + xEM]2 [ rsupercoil + xEM]2
V B, supercoil,6 = 5π2 [1/2 (rbase + xEM )2 cos (ϴhexa)sin(ϴhexa)] )]× [ rbase + xEM][ rhistone + xEM] 2 [ rsupercoil + xEM]2 (5)

Fig. 5. 5G technology waves could pass the cell membranes and lead to production of COVID-19; however the size of radio waves are more than the size of cells and thus radio waves could not pass the cell membranes.

Where rbase is the length of a base (~10-9), rhistone is the radius of histones (~10-8), rsupercoil is the radius of a supercoil (~ 10-7), ϴhexa (π/6) is the central angle of a hexagonal molecule, ϴpenta (π/5) is the central angle of pentagonal molecule, xEM is the oscillating length which has a direct relation with the wavelength of
external field:

EEM =1/2 KEM xEM 2 = h υEM = h c/ λEM (6)

Where υEM is the frequency, λEM is the wavelength of external field, c is the velocity of light and h is the plank constant. Thus, we can write the following
equation: xEM ~ λEM -1/2 (7)

We should then calculate magnetic energies and magnetic fields. We assume that a DNA acts like an inductor and thus, we write the following equation for its magnetic fields: For linear inductor:

BDNA, linear,5/6=µ0 ngene5/6 Igene,5/6 (8)

For curved inductor:

BDNA, curved,5/6=µ0 ngene5/6 Igene,5/6/2π[rhistone + λEM-1/2] (9)

For supercoils:

BDNA, curved,5/6=µ0ngene5/6 Igene,5/6/4π2 [rsupercoil + λEM -1/2]

Where ngene5/6 is the density of genes including hexagonal and pentagonal molecules (17) within DNAs, rhistone is the size of histone (3 × 10-10) (18), rsupercoil is the radius of supercoil (~ 10-9) and Igene,5/6 is there current which moves along pentagonal/hexagonal molecules of genes. We assume that each gene is in fact a long wire that is coiled around the axis of a DNA. A DNA may have 50,000 or more gene (Ngene) (17) and each gene is around 10-12 meter long (Lgene) within a cell. Thus, we can calculate density of genes (ngene):

ngene, 5/6 =Ngene/Lgene5/6 (11)
Ngene = 50000 (17) (12)
Lgene= 10-12m (19, 20) (13)
Lgene, 5/6 = 2 ×10-12 m (19, 20) (14) ngene, 5/6 = 2.5 × 1016 (15)

To calculate the value of the current along genes, we should calculate the total effective charge of all genes (Qgene,5/6) and their velocity (Vgene,5/6).
Igene,5/6 = Qgene,5/6 Vgene,5/6 (16) Effective charges of all genes are different from their normal total charges. A gene may have a few normal charges because its charges cancel the effect of each other in the static state. However, during the gene expression and DNA evolutions, each charge has a separate effect. For this reason, we should regard total charges of all genes. To obtain this charge, we should write:

Qgene,5/6 = Ngene,5/6 qgene,5/6 (17)

Where Ngene,5/6 =2 Ngene is the number of genes including pentagonal/hexagonal molecules and qgene,5/6 is the effective charge of pentagonal/hexagonal molecules in a gene. Again, we insist that effective charge of a gene is different from its normal charge. In fact, we should regard all electrons and atoms that contribute in gene expression. For this reason, we should write:

qgene,5/6 =4Nbase qbase (18)

where Nbase is the number of base pairs within a gene (17, 18) and qbase is the effective electrical charge of a base. We can put approximate numbers and obtain the effective charge of all genes:

Nbase= 109 (21, 22) (19)
qbase =(10-20) qelectron=(10-20)× 1/6 × 10-19 (20)
Qgene, 5/6 =4 ×10-4 (21)

Now, we calculate the effective velocity of genes:

Vgene, 5/6 = Lgene, 5/6 ωgene, 5/6 (22)

This velocity depends on the length of a gene

(Lgene, 5/6) and its rotating velocity (ωgene, 5/6).
Lgene, 5/6 = 2×10-12 m (19, 20) (23)

The rotating velocity of a gene (ωgene, 5/6) can be obtained by summing over rotating velocities of all its effective charges (ωcharge, 5/6):
ωgene, 5/6 = ncharge, 5/6 ωcharge, 5/6 (24) To obtain the number of charges, we multiply number of bases and number of atoms/electrons

ncharge, 5/6 = 2Nbase Natom (25)

Now, we put approximate values for numbers and obtain velocity of genes:


Nbase= 109 (21, 22) (26)
Natom =10 (27)
ncharge, 5/6 = 2 ×1010 (28)
ωcharge , 5/6 = 2π/Tcharge, 5/6 (29)
Tcharge, 5/6 =[ λEM]1/2 /c (30)
ωcharge, 5/6 =6.28 ×10 (31)
Vgene, 5/6 =2.516 × 100 (32)


Substituting values of velocity from equation (32) and charges from equation (21) in equation (16), we can obtain the current of genes:

Igene, 5/6 ~ 10-3 (33)

Putting the current from the above equation (33) and density of genes from equation (15) in equations (6-10), we calculate magnetic fields of a DNA within a cell.

BDNA, linear,5/6~ 107
[ λEM]-1/2 (34)
BDNA, curved,5/6~ 1016 [ λEM]-1 (35)
BDNA, supercoil,5/6~ 1025 [ λEM]3//2 (36)

Using these fields, we can obtain energy density of magnetic fields around a DNA within a cell.

µ0
=4π× 10-7 (37)
UB, linear,5/6 =( [BDNA, linear,5/6] 2
/2 µ0
) ~1021 [ λEM]
-1 (38)
UB, curved,5/6 =( [BDNA, curved,5/6] 2
/2 µ0
) ~1038 [ λEM]-2
(39)
UB, supercoil ,5/6 =( [BDNA, supercoil,5/6] 2
/2 µ0 ) ~1056 [ λEM] 3 (40)


Consequently, substituting above results in equation (4), total energy can be obtained from the following equation:

EDNA = [5 [1/2 (rbase + λEM -1/2)2 cos (ϴpenta)sin(ϴpenta)] [ rbase + λEM -1/2]
5 [1/2 (rbase + λEM -1/2 )2 cos (ϴhexa)sin(ϴhexa)][ rbase
λEM -1/2]] × 1021 [ λEM]-1 +[ 5π [1/2 (rbase + λEM -1/2)2 cos (ϴpenta)sin(ϴpenta)]× [ rbase + λEM -1/2][ rhistone + λEM -1/2]2
5π [1/2 (rbase + λEM -1/2 )2 cos (ϴhexa)sin(ϴhexa)] )]× [ rbase + xEM][ rhistone + λEM -1/2]2 × 1038 [ λEM]-2
[ 5π2 [1/2 (rbase + λEM -1/2 )2 cos (ϴpenta)sin(ϴpenta)]× [ rbase + xEM][ rhistone + λEM -1/2]2 [ rsupercoil + λEM -1/2]2
5π2 [1/2 (rbase + λEM -1/2)2 cos (ϴhexa)sin(ϴhexa)] )]× [ rbase + λEM - 1/2][ rhistone + λEM -1/2]2 [ rsupercoil + λEM -1/2]2 ] × 1056 [ λEM]-3 (41)


Substituting the above equation in equations (1- 3), we can obtain the probability for the amount of effects of external fields on the evolutions of DNAs
within a cell:

PDNA = exp (KS
EDNA / Tcell) / ΩDNA, tot (42)

Fig. 6. The probability of the effect of waves on the evolutions of a DNA within a cell in terms of wavelength The above probability depends on the wavelength of external fields.

In Fig. 6, we show the probability for producing hexagonal and pentagonal DNA holes within a cell. This figure indicates that by decreasing the wavelength (< 10⁻³m), waves pass the cell membrane and interact with DNAs. This interaction causes the motions of DNAs. By motions of DNAs, their charges move and emit strong waves. These waves produce hexagonal and pentagonal holes within a cell. To fill these holes, extra bases are produced. These bases could join to each other and form viruses such as COVID-19.


DISCUSSION

Our results show that, by decreasing the wave length, waves emitted from towers in 5G and higher technologies could have more effect on evolutions of DNAs within cells. This is because dermatologic cell membranes act as an antenna for these waves. They are built from charged particles,such as electrons and atoms, and could emit or receive waves. On the other hand, an antenna could only take waves in which their lengths are not greater than its size. Thus, a cell membrane could take millimeter waves in 5G technology. These waves could pass the membrane and interact with biological matters within a cell.

If wavelengths of 5G waves be equal or less than the size of a nucleus, they can pass the nuclear membrane and interact with DNAs. These DNAs are built from hexagonal and pentagonal bases and, by their motions, some holes emerge. These holes are filled by hexagonal and pentagonal extra bases which are constructed by cells. These bases could join to each other and form some viruses such as Coronavirus. It is concluded that in the next generation of mobile technology, emitted waves of towers will have more effects on biological cells.

In this research, we have shown that new generation mobile technology, like 5G, could have the main role in constructing various types of viruses, such as Coronaviruses, within a cell. Some wavelengths in these technologies are smaller than the size of biological cells and could pass the cell membrane and enter the nucleus. These waves could be taken by dermatologic antenna, transfer to host cells, interact with DNAs and move them. A DNA is formed from charged particles and, by its motions, electromagnetic waves emerge. These waves produce hexagonal and pentagonal holes in liquids within nucleus and the cell. To fill these holes, bases are produced. These bases join to each other and can construct viruses like Corona viruses.


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Originally Published : https://www.biolifesas.org/biolife/category/journals/journal-of-biological-regulators-and-homeostatic-agents/

Originally Accepted : https://pubmed.ncbi.nlm.nih.gov/32668870/

Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work

Authors : Giovanni Messina (1), Rita Polito (1), Vincenzo Monda (2), Luigi Cipolloni (1), Nunzio Di Nunno (3), Giulio Di Mizio (4), Paolo Murabito (5), Marco Carotenuto (6), Antonietta Messina (2), Daniela Pisanelli (1), Anna Valenzano (1), Giuseppe Cibelli (1), Alessia Scarinci (7), Marcellino Monda (2), Francesco Sessa (1)

  1. Department of Clinical and Experimental Medicine, University of Foggia, Italy

2. Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Università degli Studi della Campania Naples, Italy

3. Department of History, Society and Studies on Humanity, University of Salento, Lecce Italy

4. Department of Law, Forensic Medicine, Magna Graecia University of Catanzaro, Italy

5. Department of General Surgery and Medical-Surgical Specialties, University of Catania, Italy

6. Department of Mental Health, Physical and Preventive Medicine, Clinic of Child and Adolescent Neuropsychiatry, Università degli Studi della Campania Italy

7. Department of Education Sciences, Psychology and Communication, University of Bari, Italy

Abstract

Background: On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China.

The infection spread first in China and then in the rest of the world, and on the 11th of March, the WHO declared that COVID-19 was a pandemic. Taking into consideration the mortality rate of COVID-19, about 5–7%, and the percentage of positive patients admitted to intensive care units being 9–11%, it should be mandatory to consider and take all necessary measures to contain the COVID-19 infection.

Moreover, given the recent evidence in different hospitals suggesting IL-6 and TNF-α inhibitor drugs as a possible therapy for COVID-19, we aimed to highlight that a dietary intervention could be useful to prevent the infection and/or to ameliorate the outcomes during therapy. Considering that the COVID-19 infection can generate a mild or highly acute respiratory syndrome with a consequent release of pro-inflammatory cytokines, including IL-6 and TNF-α, a dietary regimen modification in order to improve the levels of adiponectin could be very useful both to prevent the infection and to take care of patients, improving their outcomes.

1. Background

On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China. About one month later (on 8 January 2020), the Chinese authorities declared the identification of a new type of coronavirus, informing the WHO a few days later that the outbreak was associated with exposure in a seafood market in Wuhan City.

The infection spread firstly in China and then in the rest of the world, and on the 11th of March, the WHO declared that COVID-19 was a pandemic.Coronaviruses (CoVs) belong to the subfamily Orthocoronavirinae in the family of Coronaviridae in the order Nidovirales, and this subfamily includes α-coronavirus, β-coronavirus, γ-coronavirus, and delta-coronavirus [1].

Coronaviruses primarily cause enzootic infections in birds and mammals and, in the last few decades, have shown to be capable of infecting humans as well [2]. In human infections with highly virulent respiratory viruses—such as avian influenza H5N1, H7N9, Severe Acute Respiratory Syndrome (SARS) coronavirus, and Coronavirus Disease-19 (COVID-19)—immunopathogenesis caused by the overproduction of pro-inflammatory cytokines may play an essential role in disease progression and mortality [3].

Several recent studies have reported that COVID-19 caused the destruction of the pulmonary parenchyma, including interstitial inflammation and extensive consolidation, similarly to the previously reported coronavirus infection [4,5]. During coronavirus infection, it was observed that the lungs increased in weight, with a mild pleural effusion of clear serous fluid, named pulmonary edema, and extensive consolidation [6,7]. In some areas, there was interstitial thickening, with mild-to-moderate fibrosis, but a disproportionately sparse infiltrate of inflammatory cells (mainly histiocytes, including multinucleated forms, and lymphocytes) [8]. A dilatation of the airspaces was observed, as was focal honeycombing fibrosis. An intra-alveolar organization of exudates was described, and the formation of granulation tissues in the small airways and airspaces was reported. These lesions were typically located in the sub-pleural region, and the cellular component mainly consisted of histiocytes, as reported in a previous paper [9]. Xu et al. described in their case report the pathological findings of COVID-19 associated with acute respiratory distress syndrome. At the X-ray investigation, they detected a rapid progression of bilateral pneumonia.

The biopsy samples were taken from the lung; the histological examination showed bilateral diffuse alveolar damage with cellular fibromyxoid exudates [6].Considering that the mortality rate of COVID-19, about 5–7% [10], and the percentage of positive patients admitted to intensive care units being 9–11% [11], it should be mandatory to consider and take all necessary measures intended to contain the viral infection.

A recent study analyzed the data of 150 COVID-19 patients, with the aim of defining the clinical predictors of mortality. The results obtained from this study suggest that COVID-19 mortality might be due to virus-activated “cytokine storm syndrome”, considering that the plasma levels of IL-6 were higher in deceased patients compared to in discharged subjects [12].Considering that a detailed study has not been performed on the immunological response to COVID-19, the only way to discuss this thematic is to refer to previous knowledge about SARS-CoV and MERS-CoV. The first response is obtained through pattern recognition receptors (PRRs) including C-type lectin-like receptors, Toll-like receptors (TLR), NOD-like receptors (NLR), and RIG-I-like receptors (RLR). Moreover, several inflammatory factors are expressed such as IL-6 and TNF-α; moreover, the synthesis of type I interferons (IFNs) is activated, and these exert their actions against virus diffusion, accelerating macrophage phagocytosis [13] (Figure 1).

Figure 1. The main immunological response to COVID-19.

In the light of these considerations and the recent evidence in different hospitals suggesting IL-6 and TNF-α inhibitor drugs as a possible therapy for COVID-19, this review aims to highlight how a dietary intervention could be useful to prevent the infection and/or to ameliorate the outcome during therapy.

2. The Pivotal Role of IL-6 and TNF-α in Lung Infections

The first laboratory report about COVID-19 patients indicated several parameters that were found to be altered in blood samples; for example, D-dimer, neutrophil count, blood urea, and creatinine levels were significantly higher. In the same way, several cytokines such as IL-6 and TNF-α were overexpressed, indicating the immune status of the patients [14].IL-6 represents pro-inflammatory signaling produced by adipose tissue; for this reason, this endocrine cytokine could be important in regulating the host response during acute infection [15].

Several papers have described the essential role of IL-6 in generating a proper immune response during different kinds of viral infection in the pulmonary tract. Others link this cytokine to an exacerbation of viral disease. These latter findings support the hypothesis that IL-6 upregulation during viral infections may promote virus survival and the exacerbation of the clinical disease [16,17].

Indeed, IL-6 has a pleiotropic function, and it is produced in response to tissue damage and infection. In particular, at the pulmonary level, innate and adaptative immune cell proliferation is strongly influenced by this cytokine. After targeting its specific receptor, IL-6 starts a cascade of signaling events mainly associated with the JAK/STAT3 activation pathway, promoting the transcription of multiple downstream genes related to cellular signaling processes, including cytokines, receptors, adaptor proteins, and protein kinase [15].

Furthermore, it has been reported that IL-6 is an essential factor for the survival of mice with a viral infection. This cytokine promotes the optimal regulation of the T-cell response, inflammatory resolution, tissue remodeling promoting lung repair, cell migration, and the phagocytic activities of macrophages, as well as preventing virus-induced apoptosis in lung epithelial cells.

However, experimental scientific evidence also suggests potential adverse consequences that increased levels of IL-6 might have on the cellular immune response against viruses. In this context, different possible mechanisms involving this cytokine might affect viral clearance, ultimately favoring the establishment of a persistent viral state in infected hosts [18,19].

Tumor necrosis factor is a cell-signaling protein (cytokine) involved in systemic inflammation, released predominately from macrophages, but it is also released from a variety of other immune cells. It has been well described that during infection with the influenza virus, the expression of TNF-α in lung epithelial cells was higher, exerting powerful anti-influenza virus activity [20].

In an animal model, it has been demonstrated that TNF-α plays a pivotal role in the development of pulmonary fibrosis. TNF-α signals via two receptors, TNF-RI and TNF-RII; the first receptor (TNF-RI) promotes intracellular signaling involving c-Jun N-terminal kinase (JNK) and nuclear factor (NF)-κB, while the other receptor, TNF-RII, promotes TNF-RI–dependent cell death, without directly inducing apoptosis. Although both receptors are broadly expressed, it is known that the majority of inflammatory signaling is elicited through TNF-RI [21].

In an in vitro model, it has been described that serine/threonine kinases can phosphorylate TNF-RI and its molecules, preventing tyrosine phosphorylation [22,23,24].In patients with COVID-19, the high serum levels of IL-6 and TNF-α are negatively correlated to T cells; contrariwise, it has been demonstrated that T cell levels were restored by reducing IL-6 and TNF-α concentrations [25]. These findings suggested that these cytokines could represent important targets of anti-COVID-19 therapies.

3. Adiponectin Function in Lung Infections

Through the secretion of adipokines, adipose tissue participates in the regulation of several pathophysiological processes in many organs and tissues. Among the adipokines, adiponectin is the most relevant. Adiponectin is one of the most abundant circulating adipocytokines, accounting for 0.01% of total serum protein. Adiponectin is an important regulator of cytokine responses, and this effect is isoform-specific. It is involved in a wide variety of physiological processes, including energy metabolism, inflammation, and vascular physiology. These effects are mediated by two atypical, widely expressed seven-transmembrane receptors, AdipoR1 and AdipoR2 [26]. Adiponectin has beneficial effects in cardiovascular systems and blood vessels, protecting these tissues through the inhibition of pro-inflammatory and hypertrophic responses and stimulation of endothelial cell responses [27].

Adiponectin circulates as three different isoforms (low molecular weight—LMW, medium molecular weight—MMW, and high molecular weight—HMW) [28].Infectious diseases are characterized by an increased production of adiponectin. Several papers suggest that adiponectin may be related to disease activity and/or severity in different conditions such as rheumatoid arthritis, osteoarthritis, and systemic lupus erythematosus. Since adiponectin has been found to display both pro- and anti-inflammatory activities, controversial findings have been observed regarding the role of total adiponectin in systemic autoimmune and inflammatory joint diseases. For this reason, the relative contribution of each adiponectin isoform to the inflammatory response and joint and/or tissue damage requires further study [29].

It is reported that adiponectin is regulated by transcription factors in adipose tissue, such as peroxisome proliferator-activated receptor-γ (PPAR-γ) [30]. During viral infections, it has been reported that the role of the predisposition of hosts is also important, as well as their state of health and nutrition. Indeed, it is well known that white adipose tissue is considered an endocrine source of biologically active substances with local and/or systemic action, called adipokines.

The inappropriate secretion of adipokines seems to participate in the pathogenesis of obesity-related diseases, including endothelial dysfunction, inflammation, and atherosclerosis [31,32,33].The biological function of adipokines in lung diseases seems to be mainly related to the inflammatory process. In particular, the intercorrelation between adipose tissue and the lung has become evident as the involvement of adiponectin has been demonstrated in several lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), emphysema, and cancer [34]. In fact, with specific regard to COPD, a low-grade inflammatory state has been demonstrated [35,36,37].

Moreover, increasing evidence suggests that adiponectin also exerts a crucial role in the vascular endothelium, maintaining vascular homeostasis and protecting against vascular dysfunctions. Altogether, these findings support the anti-inflammatory role of adiponectin in COPD and, in general, in other lung diseases [38].The critical role of adiponectin in the pathophysiological conditions of the lung is also supported by the modulation of AdipoRs with the downregulation of AdipoR2. It has been described that the adiponectin oligomerization state is altered in COPD; moreover, the presence of AdipoR1 and AdipoR2, with a lower expression of AdipoR2 compared to AdipoR1, in lung tissue [39] has been demonstrated. The low expression of AdipoR2 could suggest a specific role of this receptor, mainly implicated in adiponectin’s effects on inflammation and oxidative stress. Mainly, it has been observed that higher levels of adiponectin are associated with a significant and specific increase in HMW adiponectin, representing the most biologically active forms. Thus, HMW adiponectin increases IL-6 secretion in human monocytes and human monocytic leukemia cell lines but does not suppress lipopolysaccharide (LPS)-induced IL-6 secretion. Byn contrast, LMW adiponectin reduces LPS-mediated IL-6 release and also stimulates IL-10 secretion [40].

Furthermore, several in vitro studies have demonstrated that adiponectin in the A549 adenocarcinoma human alveolar basal epithelial cell line has an essential apoptotic effect and also reduces the production of pro-inflammatory cytokines such as TNF-α, blocking NF-κB nuclear translocation [41,42].Indeed, adiponectin can reduce innate and adaptive immune cell proliferation and polarization, also blocking the production of pro-inflammatory cytokines such as TNF-α, IL-2, and IL-6, and enhancing that of anti-inflammatory cytokines such as IL-10, with a decrease in the phosphorylation of AMPK, p38, ERK1/2, and c-JNK [43,44,45,46]. Data from in vitro studies on lung cells were consistent with an anti-inflammatory function of adiponectin, and adiponectin-deficient mouse models developed lung function impairments and systemic inflammation [47].

The possible role of adiponectin in inflammatory pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and in critical illnesses has been the subject of recent investigations. Particularly, the HMW isoform has a specific role in pulmonary diseases and critical illnesses, even if its role should be better clarified [48,49].

An interesting study reported that systemic adiponectin concentrations in humans fall during the acute phase of lung infection: particularly, during the early phase, the pro-inflammatory state is generated by the high systemic TNF-α and IL-6 concentrations, with the subsequent inhibition of adiponectin production. Contrariwise, it has been described that the reduction in TNF-α and IL-6 factors generates a corresponding bounce-back in systemic adiponectin concentrations [50].

Although it is still unclear whether the modulation of systemic adiponectin or its signaling pathways has any therapeutic benefit in pulmonary or critical illnesses, it may serve as a novel therapeutic or preventative tool for these illnesses in the future. One obvious pharmaceutical treatment would be the exogenous administration of adiponectin by the inhalational or intravenous route. Although this has been tried in mouse models [51], the problems to be overcome prior to human administration include establishing what the biologically active molecule is and what role post-translational modifications have upon its function, and the associated difficulties in generating biologically active molecules on a large scale.

Considering the difficulty linked to the direct administration of adiponectin, in the last few years, other drugs have been used that indirectly improve adiponectin production. For example, a synthetic ligand of peroxisome proliferator-activated receptors can increase adiponectin mRNA in adipocytes, improving the production and secretion of adiponectin [52,53,54,55]. Moreover, other drugs such as fibrates can increase systemic adiponectin levels by enhancing PPAR-γ activity [56,57]. Another way to improve adiponectin levels is the use of angiotensin converting enzyme inhibitors [58,59,60]. Furthermore, it is possible to stimulate adipocyte differentiation [61] and the activation of PPAR [62].

Finally, it has been described that calcium channel blockers [63] and a central-acting anti-hypertensive agent [64] also increase systemic adiponectin concentrations [65]. The possibility to improve the action of adiponectin through diet is intriguing; it has been described that nutritional interventions may help to regulate systemic adiponectin concentrations. In an animal model, it has been demonstrated that a diet with a high concentration of polyunsaturated fatty acids and supplemented with ω-3 can improve the plasma levels of adiponectin, increasing gene expression [66]. On the other hand, in humans, adiponectin levels are positively associated with a healthy lifestyle and the Mediterranean diet, even if the mechanisms of action are not completely known [66]. Finally, in light of these considerations, in COVID-19 therapy, it could be very useful to combine drug therapy with a specific diet regimen.

4. ω-3 PUFAs and Lung Infections

Another important mediator involved in the immune response and influenced by nutrition are fatty acids, in particular, ω-3 PUFAs [67,68]. In fact, during bacterial and viral infections, they are able to act on immune cells and regulate diverse inflammatory processes. ω-3 PUFAs are known to have anti-inflammatory properties and play an essential role in the resolution of inflammation [69].

In several lung infections, the administration of PUFA can ameliorate the outcome of the patient in acute pneumonia. Sharma et al. reported in their study that the dietary supplementation of ω-3 PUFA can exert an overall beneficial effect against acute pneumonia through the upregulation of the host’s specific and nonspecific immune defenses [70]. ω-3 polyunsaturated fatty acids (PUFA, ω-3-fatty acids), the key components of fish and flaxseed oils, are increasingly consumed by the public because of their potential health benefits and can be used clinically for the treatment of metabolic, cardiac, inflammatory, and autoimmune diseases [71].

However, numerous studies have shown that these compounds are immunoregulatory and immunosuppressive and thus may increase susceptibility to infection. While reports suggest that ω-3 PUFAs may have beneficial effects against extracellular pathogens, few studies have been performed on systemic viral infections in mammals. Jones and Roper described in their study that a diet rich in ω-3 PUFAs did not significantly lower survival of the vaccinia virus infection, at least with short-term (~6 week) feeding in mice [71].

ω-3 PUFAs are metabolized into various mediators possessing anti-inflammatory properties such as resolvins and protectins. It is known that ω-3 PUFAs can reduce NF-κB activation by preventing nuclear p65 NF-κB translocation. Furthermore, ω-3 PUFAs minimize the activation of ERK1/2 MAPK, also reducing COX-2 production. The ω-3 PUFA-derived lipid mediator could markedly attenuate influenza virus replication via the RNA export machinery. In addition, the treatment of protectin D1 with peramivir could completely stop mouse mortality [72].

ω-3 supplementation was previously studied in Acute Respiratory Distress Syndrome (ARDS). Singer and Shapiro suggested that the enteral administration of natural antioxidant substances could improve oxygenation and clinical outcomes in ICU patients [73]. A systematic review performed in 2015 reported a positive effect only for patients suffering from ARDS with high mortality [74]. A more recent meta-analysis highlighted the importance of clinical trials in order to clarify the use of ω-3 fatty acids and antioxidants in patients with ARDS to ascertain the positive effects in order to reduce the lengths of ICU stays and the numbers of days spent on ventilators [75].

Although the role of ω-3 supplementation in ARDS should be better clarified, its pivotal role in reducing reactive oxygen species and pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-8 [76], is well known.Therefore, ω-3 PUFAs, including protectin D1, which is a novel antiviral drug, could be considered for potential interventions for COVID-19.

5. Other Dietary Constituents and Lung Infections

As previously described, other dietary constituents can be used to improve the patients’ outcomes during lung infection, regulating the inflammatory response. Among these, antioxidants play an important role in protecting lung cells against viruses and bacteria. Viral infection leads to an increase in the intrapulmonary oxidative burden. In many diseases, the balance between oxidants and antioxidants (redox balance) is altered, with severe consequences [77].

The pathophysiological mechanisms by which free radicals generate various types of stress—such as oxidative, nitrative, carbonyl, inflammatory, and endoplasmic reticulum stress—lead to lung inflammation and an altered lung immune response. In this scenario, dietary antioxidants may play an important role against lung oxidative stress [77].

Several studies reported the protective role of the antioxidants in lung infection and in lung inflammation [78,79].In particular, vitamin C, polyphenols, and flavonoids can play a protective role in lung infections, being immune modulators and inflammatory mediators. Indeed, as reported by Carr et al., during infection, vitamin C levels may become depleted; for this reason, vitamin C supplementation can attenuate infection. Based on this evidence, these authors suggested a clinical trial with vitamin C infusion for the treatment of severe COVID-19 patients [80].

Among polyphenols, epigallo-catechin 3 gallate (EGCG) is the most potent ingredient in green tea and exhibits antibacterial, antiviral, antioxidative, anticancer, and chemo-preventive activities. Recently, numerous studies have investigated the protective effects of EGCG against asthma and other lung diseases such as COPD and lung pneumonia. EGCG may suppress inflammation and inflammatory cell infiltration into the lungs of asthmatic mice, and may also inhibit epithelial-mesenchymal transition EMT via the PI3K/Akt signaling pathway through upregulating the expression of phosphatase and tensin homolog (PTEN), both in vivo and in vitro [81].

Moreover, flavonoids can be used to attenuate lung injury in mice; it has been reported that they inhibit influenza virus and Toll-like receptor signaling, blocking NF-κB translocation [82].Therefore, as summarized in Table 1, supplementation with vitamin C, flavonoids, and polyphenols can be tested in COVID-19 patients, both in order to prevent viral infection and to improve patients’ outcomes.

Table 1. The principal antioxidants involved in lung infection and the immune-inflammatory response.

6. Discussion and Conclusions

During pulmonary infections, and particularly in COVID-19 patients, intracellular signaling leads to the production of pro-inflammatory cytokines, such as TNF-α and IL-6, which act in concert with chemoattractants, such as CXCL1 and CXCL2, to recruit polymorphonuclear leukocytes (PMNs) to the lungs, killing pathogens but generating fibrosis [83].

Another important consideration during COVID-19 infection is related to the modification of the secretory products of the upper and lower airways, which usually include mucin and pulmonary surfactant. During infection, mucin production is upregulated, with the function of preventing microbes from binding to and infecting epithelial cells [84].

The primary source of phospholipids (PLs) in the lung is pulmonary surfactant, synthesized and released by alveolar epithelial type II cells. The surfactant contains approximately 80–90% PLs, with fatty acid chains that can be oxidized during different challenges in the lung [85]. The oxidation of these PLs in the lung can occur in the setting of an increased oxidative stress situation, such as infection and inflammation [86]. The immune effects of oxidized phospholipids oxPLs during infectious diseases are inevitably dictated by the balance among activation, degradation, and scavenging. It has been shown that oxPLs are generated in the lung during several pulmonary infections, including influenza and avian influenza (H5N1), as well as SARS coronavirus, even if the mechanisms of action are not well known [87,88,89].

As reported by Imai et al., oxPL-induced inflammation is mediated by TLR4 and TRIF, driving an increase in IL-6 production [89]. It is intriguing to consider that oxPL-dependent defects in phagocytosis and ROS generation may lead to an increased susceptibility to respiratory infections [90]. Cholesterol is the major neutral lipid in pulmonary surfactant, in which it is thought to promote the spreading, mobility, and adsorption of surfactant films [91].

As previously documented, modulating adiponectin levels can be considered an important way to reduce cytokines levels; in this way, the adverse effects related to the COVID-19 infection should be attenuated. It is well described in animal models that the consumption of hyperlipidemic diets, rich in saturated fat, reduces the levels of adiponectin, while diets rich in polyunsaturated fatty acids and supplemented with ω-3 PUFA increase adiponectin levels, reducing pro-inflammatory cytokines [66].Innate and adaptive immune responses are influenced not only by oxPLs and cholesterol but also by the fatty acid profiles of tissues in response to pharmacological agents and diet [92].

Several studies performed in animal models demonstrated how ω-3 PUFA uptake into the lung tissue influences outcomes associated with infection, promoting the resolution of inflammation [93]. In another study, ω-3 PUFAs reduced the levels of PMNs and lowered IL-6 levels in lung infections [94]. These positive effects remain controversial; for example, Jones and Roper reported that in their experimental model, no statistically significant differences were found among the diet regimens, with and without ω-3 PUFAs, with respect to the susceptibility of mice to viral infection, morbidity, viral organ titers, recovery time, or mortality [71].

In conclusion, it is well known that general treatments are very important to enhance the host immune response against RNA viral infection. In addition, the immune response has often been shown to be weakened by inadequate nutrition in many model systems as well as in human studies. However, the nutritional status of the host, until recently, has not been considered as a contributing factor to the emergence of viral infectious diseases. The recent reports about the pathogenesis of COVID-19 suggested that one of the most important consequences of this infection is the cytokine storm syndrome [95], which could be strictly linked with coagulopathy, generating acute pulmonary embolism caused by in-situ thrombosis [96,97]. Therefore, a great number of clinical trials are ongoing to define a useful therapy to attenuate cytokine storms [98].For these reasons, an adequate ω-3 PUFA intake may be a valid strategy against viral infection.

Indeed, following the recommended intake of ω-3 PUFA, in the range of 0.5% and 2% of total calories (250 mg/day), may be important to protect against an excessive inflammatory response, also reducing IL-6 levels. This theory found important support in a recent study that demonstrated that ω-3 PUFA-derived lipid mediator protectins can suppress influenza virus replication through a mechanism that blocks the export of viral mRNA. Moreover, Imai demonstrated that this mediator can be used in combination with the antiviral peramivir, even at late time points in infection [99].

Nevertheless, the efficacy of ω-3 PUFAs at the clinical level is under investigation; for example, Hecker et al. described a beneficial effect for a diet regimen with ω-3 PUFAs, describing that the pro-inflammatory cytokine levels decreased after this diet regimen [100]. The suggested positive role in the outcome and prevention of the COVID-19 infection is summarized in Figure 2.

Figure 2. Adiponectin and ω-3 PUFAs reduce the lung inflammation that occurs following coronavirus infection, reducing IL-6 production, ERK1/2, and COX-2 activation and the nuclear translocation of NF-κB.

In addition, adiponectin plays a role in lung diseases and obesity; in the development and progression of lung disease and cancer, a pathogenic role of adiponectin was defined by both in vivo and in vitro studies.

Recently, immunometabolic pathomechanisms have been identified as important factors determining and modulating lung function and disease. Particularly, adiponectin levels have been found to be greater in patients with COPD compared with in control patients, and adiponectin-deficient mice are protected from several lung diseases [101].

Moreover, it has been reported that adherence to the Mediterranean diet was associated with an increase in adiponectin levels, improving cardiovascular system functionality [102], particularly in elderly people [103]. These findings are only apparently contradictory to the first data about the mortality rate from COVID-19 infections in the Mediterranean area (such as in Italy and Spain) [104].

First of all, the data have been referred only to the tested population; moreover, it is well described that the presence of several comorbidities such as hypertension, diabetes, and cardiovascular diseases severely influenced the mortality rate reported in this area [105].

All these comorbidities can be counteracted with a correct dietary regimen. Therefore, both adiponectin and ω-3 PUFAs appear to be attractive biomarkers for monitoring lung disease progression.

Finally, considering that the COVID-19 infection can generate a mild or highly acute respiratory syndrome with a consequent release of pro-inflammatory cytokines, including IL-6 and TNF-α, a modification of the dietary regimen in order to improve the levels of adiponectin could be very useful both to prevent the infection and to take care of the patients, improving their outcomes.

Given the similar pathway of action, it can be hypothesized that adiponectin and ω-3-PUFA could be used as real drugs to reduce inflammation, reducing both IL-6 and TNF-α levels as well as ameliorating the lung damage that occurs following coronavirus infection.

Investigation into Electrons, Oxygen, Nutrition, pH and COVID (or 5G!)

This is a ramble, of the threads of thought which are on my mind. In time this may be edited and streamlined, but presently I feel it paints a picture that may help others. It is clear something deep is happening in the world, bigger than just COVID in my opinion. So it will start with a long article about using H2O2 and wander on from there.

Surviving the Coronavirus Disease, How Hydrogen Peroxide Works

By Paul Ebeling on April 9, 2020

Hydrogen Peroxide Has a Long History of Medical Use

Hydrogen peroxide (H2O2) consists of a water molecule (H2O) with an extra oxygen atom.

The oxygen inactivates viral pathogens by breaking down the viral structure

Additionally, our immune cells produce hydrogen peroxide. This is in part how your immune system kills infected cells. Hydrogen peroxide therapy aids aids immune cells to perform their natural function more effectively.

H202 is on the shelf at the local grocery or drug store for $1.00 a bottle.

The Big Q: Can an inexpensive and easy to administer at-home treatment treat the novel coronavirus, SARS-CoV-2?

The Big A: Dr. Thomas Levy says Yes. The remedy is hydrogen peroxide H202, aerosolized in any standard nebulizer.

It’s worth keeping in mind that while the elderly and those with underlying medical conditions are at increased risk of serious complications and death, the overall mortality rate of COVID-19 is quite low, and very similar to the flu.

A compilation of reported mortality statistics from around the world can be found in the paper,“Likelihood of Survival of Coronavirus Disease 2019,” published in The Lancet Infectious Diseases, 30 March 2020.

For the latest up to the min COVID-19 resources click here.

To perform this treatment, you need but two items: a nebulizer with a face mask that covers your mouth and nose that emits a fine mist, and common household 3% hydrogen peroxide, available at most grocery stores and pharmacies for less than $1.

However, you may choose to purchase the more expensive food grade hydrogen peroxide as it doesn’t have any stabilizers in it. Stabilizers are proprietary and companies do not need to disclose them on the label, but some can be problematic.

Typically food grade peroxide comes in concentrations higher than 3% so if you chose it your will need to dilute it down to 3% to use it.

Viruses are not “alive” they need a live host in which they can infect live cells that then replicate the viral DNA and RNA. Once a cell is infected, newly replicated viruses exit the cell and move on to the next cell to duplicate the process.

So, when they talk about “killing” a virus, they are talking about inactivating them by breaking down their structure. This is why soap works so well. Coronaviruses are held together by a lipid (fatty) coating. Soap, being amphipathic, meaning it can dissolve most molecules dissolves this fat membrane, causing the virus to fall apart and become harmless.

More specifically, the fat-like substances in soap are structurally similar to the lipids found in the virus membrane, so the soap molecules compete with and replace the fats in the membrane. In so doing, the “fatty glue” holding the virus together dissolves.

Hydrogen peroxide works in a similar way. As noted by Dr. Levy, “the way to control any viral infection is not to kill the virus; rather, the infected cells that have been turned into viral factories must be killed.” 

Our immune cells actually produce hydrogen peroxide. This is in part how the immune system kills cells that have been infected with a virus. By killing the infected cell, viral reproduction is stopped. So, hydrogen peroxide therapy is in essence only aiding our immune cells to perform their natural function more effectively.

Hydrogen peroxide is also a Key redox signaling agent.

“At the low physiological levels in the nanomolar range, H2O2 is the major agent signaling through specific protein targets, which engage in metabolic regulation and stress responses to support cellular adaptation to a changing environment and stress …

Recent methodological advances permit the assessment of molecular interactions of specific ROS [reactive oxygen species] molecules with specific targets in redox signaling pathways.

Accordingly, major advances have occurred in understanding the role of these oxidants in physiology and disease, including the nervous, cardiovascular and immune systems, skeletal muscle and metabolic regulation as well as ageing and cancer.

In the past, unspecific elimination of ROS by use of low molecular mass antioxidant compounds was not successful in counteracting disease initiation and progression in clinical trials. However, controlling specific ROS-mediated signaling pathways by selective targeting offers a perspective for a future of more refined redox medicine.”

In short, hydrogen peroxide is a major ROS, but while ROS are typically thought of as “all bad,” this is a gross oversimplification.

As noted: “Steady-state physiological flux of H2O2 to specific protein targets leads to reversible oxidation, thereby altering protein activity, localization and interactions, which contributes to orchestration of various processes in cells and organs, including cell proliferation, differentiation, migration and angiogenesis. This state of low-level H2O2 maintenance and its associated physiological redox signaling is called ‘oxidative eustress.’”

Contrary to oxidative stress or oxidative distress, oxidative eustress denotes an oxidative challenge that has positive or beneficial effects and is essential in redox signaling.

The Studies: What they tells us

The most relevant study is 1 that was done earlier this year in the Journal of Hospital Infection. They studies 0.5% hydrogen peroxide, 6X weaker than the 3% typically used, and found that it killed human coronaviruses and SARS corona viruses and MERS.

Another study, published in the American Journal of Infection Control in Y 2009, assessed the efficacy of vaporized hydrogen peroxide against viruses on various surfaces, finding exposure to hydrogen peroxide vapor at a concentration of 10 parts per million resulted in 99% inactivation after 2.5 mins.

And a Y 2014 study in the Journal of Hospital Infection found hydrogen peroxide vapor eliminated an array of viruses on stainless steel, including human adenovirus 1, transmissible gastroenteritis coronavirus of pigs (TGEV, a SARS-CoV surrogate), avian influenza virus and swine influenza virus.

According to the authors, “Hydrogen peroxide vapor was virucidal against feline calicivirus, adenovirus, TGEV and avian influenza virus at the lowest vaporized volume tested (25 mL).” Vaporized hydrogen peroxide was found to completely inactivate a range of exotic animal viruses in a Y 1997 study as well.

Hydrogen peroxide’s ability to inactivate dangerous infectious viruses has also been highlighted in vaccine science. As noted in a Y 2016 study in the Vaccine journal, 3% hydrogen peroxide completely and irreversibly inactivated the rabies virus within 2 hrs, thus reducing time and cost of the inactivation process required for the making of a rabies vaccine, which contains inactivated rabies virus.

The most convenient to receive H202 is to inhale its mist, using a nebulizer a small, handheld device that converts liquid into a very fine mist.

The microscopic mist, similar to smoke or vapor, can be comfortably inhaled deep into the nostrils, sinuses and lungs. While nebulizers have routinely been used by asthmatics to deliver medication into their lungs, this delivery system affects not only the lungs but your entire body.

As noted in the Y 2002 review article, “Pulmonary Drug Delivery Systems: Recent Developments and Prospects,” “Targeting drug delivery into the lungs has become one of the most important aspects of systemic … drug delivery systems.

In the case of respiratory infections, the nebulizer has the added advantage of delivering the hydrogen peroxide right to the areas most affected by respiratory viruses: the sinuses, throat, bronchial tract and lungs.

Dr. Levy writes: “Effective hydrogen peroxide nebulization quite literally, ‘chops the head off of the snake,’ and the virus present elsewhere in the body can then readily be mopped up when the new virus influx has been terminated,” 

It should be kept in mind that hydrogen peroxide kills pathogens very readily upon contact in an open wound. It should, therefore, be understandable why putting a fine mist of hydrogen peroxide in all the areas of maximal viral replication promptly puts the body on a pathway to rapid healing.”

 Hydrogen Peroxide Protocol

To prevent an infection from taking hold, begin treatment at 1st signs of symptoms. Commercially available 3% hydrogen peroxide is fine for this purpose, and can be used without dilution.

If the undiluted solution stings or burns your nose, you can dilute it up to 50% with pure water. Even lower concentrations can be used, although the antiviral effects will be reduced at lower concentrations.

If already presenting with runny nose or sore throat, Dr. Levy recommends using the nebulizer for 10 to 15 mins 4X a day until the symptoms are relieved. You can also nebulized hydrogen peroxide for prevention and maintenance, which may be advisable during flu season, or while the COVID-19 pandemic is in full swing.

He notes: “As it is a completely non-toxic therapy, nebulization can be administered as often as desired. If done on a daily basis at least once, a very positive impact on bowel and gut function will often be realized as killing the chronic pathogen colonization present in most noses and throats stops the 24/7 swallowing of these pathogens and their associated toxins.

If daily prevention is not a practical option, the effectiveness of this treatment is optimized when somebody sneezes in your face or you finally get off of the plane after a trans-Atlantic flight. Do not wait for initial symptoms. Just nebulize at your 1st opportunity.”

Eat healthy, Be healthy, Live lively

Source:

https://www.livetradingnews.com/surviving-the-coronavirus-disease-how-hydrogen-peroxide-works-172241.html

ChooseLife : In Mid February I ordered and started using a Nebulizer with 1.5% H2O2 – http://chooselife.co.uk/index.php/2020/02/28/bill-munro-vs-the-coronavirus/

The Dr is bullish in his convictions, however there are associated risks to taking H2O2, perhaps mild or moderate, but they should be discussed, to best inform the reader.

Oxidative Stress may lead to the following :

Oxygen is crucial to life; however, when we use oxygen our bodies constantly produce free radicals. Free radicals are chemically unstable molecules or atoms. They also make other molecules or atoms in the body very unstable, thus damaging proteins, cell membranes, and even DNA structure. This is a process which can lead to permanent damage to cells and tissues resulting in infection, mental decline, depressed immunity system, joint disease, and heart disease. Free radicals are also considered to play an important role in the aging process.

Catalase is constantly in battle against the effect of free radicals to the body. It transforms harmful superoxide radicals into hydrogen peroxide which later breaks down into water and oxygen.

https://sciencing.com/role-catalase-5521462.html

The enzyme Catalase is a key buffer for these dangers, Grey hair may be an indication of inhibited (or low) Catalase production, here are Vegetarian/Vegan food sources:

Vegetarian Sources of Catalase

Written by Don Amerman

Catalase — found throughout nature in the cells of organisms that grow in the presence of oxygen — is an enzyme with potent antioxidant properties. The enzyme facilitates the breakdown of hydrogen peroxide into its harmless components — water and oxygen. Without catalase, the hydrogen peroxide that your body produces during the metabolic process would build up to toxic levels. Catalase occurs naturally in a wide array of plant-based foods, ensuring its availability to vegetarians and vegans.

Age-Related Decline in Catalase

The cells in your body can produce catalase as well as other antioxidant enzymes, such as glutathione peroxidase and superoxide dismutase, or SOD. These enzymes help to neutralize free radicals, according to the authors of “Biology: A Human Emphasis.” Free radicals are atoms or molecules with unpaired electrons that are the byproduct of human biological reactions such as metabolism. Scientists cite free radicals as causative factors in disease and aging-related cell damage. As you age, your body gradually produces less catalase, which results in a buildup of free radicals and an increase in the damage they can cause. To help supplement your body’s declining output of catalase, consume foods that are rich in this vital enzyme.

Garlic, Onions and Their Kin

Nutritionists give members of the allium plant family, which encompasses garlic, leeks, onions and shallots, high praise for their antioxidant properties. Among the cellular antioxidants naturally occurring in allium vegetables is catalase. In a study related to the catalase in allium family members, a team of Hungarian and Romanian researchers evaluated the effects of water stress on the level and activity of catalase and other antioxidant enzymes in these plants. They found that allium plants subjected to water deprivation had increased catalase levels and activity, according to an article published in a 2007 issue of “Plant, Soil and Environment.”

Cruciferous Vegetables

Cruciferous vegetables, including broccoli, cabbage, kale and collard and turnip greens, are rich in catalase. Eating plenty of these green leafy vegetables also stimulates your body’s production of catalase. Researchers at Alabama A&M University conducted an animal study to determine what, if any, anticancer effects could be observed in laboratory rats that were fed a diet of these vegetables. As part of this study, they measured the level of catalase in test animals and found that those fed cruciferous vegetables had sharply higher amounts of catalase in their livers than those animals that were not fed these vegetables. Results of this study were published in a 2012 issue of “International Journal of Cancer Research.”

Other Sources

Wheat sprouts contain high levels of catalase, according to a study by molecular biology researchers at Italy’s University of Perugia. In an article published in the July 2004 issue of the “Journal of Clinical Gastroenterology,” they note that the antioxidant activity of catalase and peroxidase in wheat sprouts is extremely strong. Other vegetarian sources of catalase include apricots, avocados, carrots, cherries, cucumbers, parsnips, potatoes, radishes, spinach and zucchini.

https://healthyeating.sfgate.com/vegetarian-sources-catalase-3693.html

ChooseLife : Parallel to this, is the issues reported of bronchial constriction. This would lead to the thinking that Magnesium Sulphate may be a solid companion to H2O2.

Effect of magnesium sulfate on bronchoconstriction in the lung periphery.

Abstract

Magnesium sulfate has been shown to be effective clinically as a bronchodilator, but its mechanism of action is unknown. We used a wedged bronchoscope technique to study the ability of MgSO4 at clinically relevant concentrations to attenuate hypocapnia-, acetylcholine- (ACh), and dry air-induced bronchoconstriction in the canine lung periphery. Control experiments demonstrated that consecutive challenges of either hypocapnia or ACh resulted in greater collateral system resistance (Rcs) after the second challenge compared with the first. Intravenous infusion of MgSO4 diminished the maximum response to a second hypocapnic challenge (Rcs = 1.59 +/- 0.29 cmH2O.ml-1.s prechallenge vs. 1.12 +/- 0.20 postchallenge) but had no effect on either ACh- or dry air-induced bronchoconstriction. Serum magnesium levels before MgSO4 administration were 1.59 +/- 0.04 meq/l and rose to 6.20 +/- 0.13 during the infusion. Previous studies demonstrated that nifedipine, like MgSO4 in this study, attenuates hypocapnia-induced bronchoconstriction in the canine lung periphery but has no effect on ACh- or dry air-induced bronchoconstriction. We conclude that these results are consistent with the idea that, like nifedipine, magnesium acts in the airway as a voltage-sensitive calcium channel blocker.

https://www.ncbi.nlm.nih.gov/pubmed/2501286/

ChooseLife : Magnesium is also an Electron reducing agent, hence it may donate Electron potential to the free Oxygen released as Catalase supports the body to reduce H2O2 into H2O and 0xygen.

This links to this information, as I see this Disease as an Electron Crisis :

From Wikipedia article NADH section 4.2 Role in redox metabolism:

[QUOTE][…] reduced compounds such as glucose and fatty acids are oxidized, thereby releasing energy. This energy is transferred to NAD++ by reduction to NADH, as part of beta oxidationglycolysis, and the citric acid cycle. In eukaryotes the electrons carried by the NADH that is produced in the cytoplasm are transferred into the mitochondrion (to reduce mitochondrial NAD++) by mitochondrial shuttles, such as the malate-aspartate shuttle. The mitochondrial NADH is then oxidized in turn by the electron transport chain, which pumps protons across a membrane and generates ATP through oxidative phosphorylation.[/QUOTE]

From Wikipedia article FADH2:

[QUOTE]FAD can exist in four different redox states, which are the flavin-N(5)-oxidequinonesemiquinone, and hydroquinoneFAD is converted between these states by accepting or donating electrons. FAD, in its fully oxidized form, or quinone form, accepts two electrons and two protons to become FADH22 (hydroquinone form). The semiquinone (FADH) can be formed by either reduction of FAD or oxidation of FADH22 by accepting or donating one electron and one proton, respectively.[/QUOTE]

Chloroquine was shown to inhibit quinone reductase 2 , a structural neighbour of UDP-N-acetylglucosamine 2-epimerases that are involved in the biosynthesis of sialic acids. The sialic acids are acidic monosaccharides found at the extremity of sugar chains present on cell” 

https://www.sciencedirect.com/science/article/pii/S0924857920300881

ChooseLife : This links together the researchers and testing of hydroxychloroquine. Is this not an Electron cascade crisis? Or a pH crisis which manifests into/from Electron deficiency? Whether this is from a Virus, or 5G, the results are the same, the treatments are the same in need… Though the overlap in effects from the Virus and the reported dangers of 5G are startling, to say the least. It is no wonder getting sunlight, or Vitamin D (Protons) is postulated often as a key player in this illness crisis.

This would make sense that Zinc with chloroquine is showing great promise in tests, as Zinc again is an Electron donor, like Magnesium…

Here it is worth also noting that Johanna Budwig contributed huge research and understanding of Electron dynamics, and stated very vigorously that it is Flax Seeds which have the highest level of Electron surplus, she found in her research that taking high levels of Flaxseed Oil, mixed with Quark (1 part Flaxseed Oil, 2 parts Quark, making it water soluble) was the most efficient mechanism possible to re-invogorate the human ‘Electron Cloud’

Interestingly, in her booklet:

Flax Oil As A True Aid Against Arthritis, Heart Infarction, Cancer And Other Diseases

Dr Budwig relayed:

I often take very sick cancer patients away from hospital where they are said to have only a few days left to live, or perhaps only a few hours. This is mostly accompanied by very good results. The very first thing which these patients and their families tell me is that, in the hospital, it was said that they could no longer urinate or produce bowel movements. They suffered from dry coughing without being able to bring up any mucous.


Every- thing was blocked. It greatly encourages them when suddenly, in all these symptoms, the surface-active fats with their wealth of electrons, start reactivating the vital functions and the patient immediately begins to feel better. It is very interesting to ask how this sudden change is possible. It has to do with the reaction patterns, with the character of electrons. I will return to these electrons later. In the last two years I have come to be very fond of them. A friend of my work in Paris wrote to me how wonderful it is that you have discovered the original birthplace of the electrons in seed oils to be the sun. That’s how these connections are made!

ChooseLife : As soon as I heard about COVID, and the chief symptom of dry cough, I though about the Budwig book and that paragraph above shouted at me. Flax (ALA) I knew was a key supportive element, yet at that stage I did not see the larger context.

Further to this, a new to air youtuber – Ava Green, has become viral, after relating her experiences with Diamox and the alignment of it’s usage and the COVID symptoms : Almost High Altitude Sickness

Pulmonary Edema, Diamox (acetylzolamide) increases Urine pH, relieving this issue:

https://www.cureus.com/articles/29004-acetazolamide-nifedipine-and-phosphodiesterase-inhibitors-rationale-for-their-utilization-as-adjunctive-countermeasures-in-the-treatment-of-coronavirus-disease-2019-covid-19

However, Pulmonary Edema is usually characterised as symptomatic of ‘Productive Cough’ or ‘Wet Cough’ not ‘Dry Cough’. Countless reports I have seen suggest quite the opposite, that the pneumonia/illness type is a very sticky mucus laiden lungs when scanned, hence a dry cough.

So, this drug may hold potential, chiefly via the increasing of urine pH, but has a multitude of nasty potential side effects, a diet with 75% fruit and vegetables is shown to raise Urine pH similarly in 3days, without the nasty side effects, in fact the other effects of this shift in diet, if green foods based, are multitude in potential positives. Mental health may be supported with the richer Magnesium this form of eating may bring (Mental Health Reviews – Magnesium).

This form of eating 75% Fruit and Vegetables, with a strong Alkaline influence (lots of leafy greens especially), if coupled with high Flax intake via a Budwig mix, is shown scientifically to elevate Metabolic and Respiratory status away from Acid and towards neutral (the author does not believe an Alkaline state is any more healthful than acidic, it is the balance which gives the reactive force, and allows the body to extract the electromagnetic energies in foods which in turn release their stored nutrients).

Altitude sickness style illness is what this Dr from New York claims he is seeing:

Oxygen Failure? ARDS may be Lung Injury Caused by the ventillators? Something is not right.

This Doctor, who is leading a COVID ICU, does it not sound like the symptoms you may expect to see if the 5G side effects are correct, Oxygen oscillation acceleration making uptake into the bloodstream troublesome, as the spin of Electrons become too fast to bind with Hemoglobin? It certainly seems that way to me. New York is a 5G pilot city, London, Wuhan. The Doctor says the effects are like how he envisages one would encounter if someone without acclimitisation were dropped at the top of Mount Everest…

This reflection, or speculation, of Altitude Sickness, reminded me of when I saw a documentary of Westerners climbing Mount Everest, in the Documentary I was struck that a much older Gurkha was carrying the Westerners very considerable Luggage, yet was able to smoke ceaselessly! This aligns to the statistics that are showing that a disproportionately low number of Smokers are being admitted to Hospital with COVID, are the smokers already attuned to Hypoxia like conditions and their biochemistry has been attuned coping mechanisms, like the Gurkha in Nepal? Of course he was acclimitised, but it was still staggering his body could cope in those conditions, when the younger, very fit, climber was struggling in the lower oxygen environment.

80% of those needing Ventillation in New York are dying, what if this is because 5G is in almost all the Hospitals in New York? Making the Oxygen Electrons spin too fast, forcefully adding more oxygen may only increase this damage, in those with Electron buffering insufficiency needed to take this sped up Oxygen into Hemoglobin? This paper supports this idea:

COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the
Porphyrin to Inhibit Human Heme Metabolism

Abstract
The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory infection caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus.

In this study, conserved domain analysis, homology modeling, and molecular docking were used to compare the biological roles of certain proteins of the novel coronavirus. The results showed the ORF8 and surface glycoprotein could bind to the porphyrin, respectively. At the same time, orf1ab, ORF10, and ORF3a proteins could coordinate attack the heme on the 1-beta chain of hemoglobin to dissociate the iron to form the porphyrin.

The attack will cause less and less hemoglobin that can carry oxygen and carbon dioxide. The lung cells have extremely intense poisoning and inflammatory due to the inability to exchange carbon dioxide and oxygen frequently, which eventually results in ground-glass-like lung images.

The mechanism also interfered with the normal heme anabolic pathway of the human body, is expected to result in human disease. According to the validation analysis of these finds, chloroquine could prevent orf1ab, ORF3a, and ORF10 to attack the heme to form the porphyrin, and inhibit the binding of ORF8 and surface glycoproteins to porphyrins to a certain extent, effectively relieve the symptoms of respiratory distress. Favipiravir could inhibit the envelope protein and ORF7a protein bind to porphyrin, prevent the virus from entering host cells, and catching free porphyrins. Because the novel coronavirus is dependent on porphyrins, it may originate
from an ancient virus. Therefore, this research is of high value to contemporary biological experiments, disease prevention, and clinical treatment.

ChooseLife :This could be seen as supporting the 5G hypothesis, it does to me, ALARM BELLS ARE RINGING. Chloroquine is suggested again, and links the Electron issue, covered early in this ramble.

This leads me to this research paper:

Cellular Response to Cigarette Smoke and Oxidants

Adapting to Survive

André M. Cantin

Abstract

The gaseous and soluble phases of cigarette smoke are sources of oxidants that contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Chronic oxidative stress of cigarette smoking induces mucus secretion and inhibits cystic fibrosis transmembrane conductance regulator function. The increased mucus viscosity renders the airways susceptible to bacterial infections, a hallmark of chronic bronchitis. Furthermore, lungs chronically exposed to the toxic mixture of oxidants in cigarette smoke show signs of endoplasmic reticulum stress, unfolded protein response, altered ceramide metabolism, and apoptosis. Fortunately, the respiratory tract has developed effective adaptive cellular mechanisms to limit oxidant damage. Numerous antioxidant enzymes and glutathione-dependent detoxification systems are increased in healthy smokers. The regulation of the antioxidant response is largely dependent on the nuclear factor erythroid 2–related factor-2 (Nrf2) pathway. However, patients with COPD have defective Nrf2 responses. Novel therapies such as 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) to correct defective Nrf2-dependent cellular response may hold promise for patients with COPD.

https://www.atsjournals.org/doi/full/10.1513/pats.201001-014AW

ChooseLife : So, we could see the above as suggesting that healthy smokers bodies may be acclimitised to this Hypoxia type state? Like the old Nepalese Smoker being better able to cope not only with thin air, but also smoke constantly in that environment, the similarities seem stark, however the dry unproductive cough symptom is a key differentiator to HAPE symptoms.

Dry Lungs Low Oxygen 70-80% of cases, called Type L not typical of HAPE

This research area, led me to the following research, when checking into Bronchial dilation (debating in my mind if Magnesium Sulphate is contraidicatd by the above video/Doctor):

CT Features of Coronavirus Disease 2019 (COVID-19) Pneumonia in 62 Patients in Wuhan, China

A decreased lymphocyte count and an increased high-sensitivity C-reactive protein level were the most common laboratory findings.


Read More: https://www.ajronline.org/doi/full/10.2214/AJR.20.22975

Omega3 is known to support lymphocyte production :

Effect of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on inflammatory and immune function in postoperative patients with gastrointestinal malignancy

A meta-analysis of randomized control trials in China

In this study, lymphocyte count was significantly higher in ω-3 groups than the control groups. Omega-3 PUFAs improve the body’s defense system by the proliferation of lymphocytes, and the meta-analysis result also confirmed that the incidence of infectious complications in ω-3 groups was significantly lower than the control group.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916652/

This again says to me Metabolic Acidosis is encountered, the Lyposomes/Endosome Cargo carriers and waste removal system appears to become compromised, this is symptomtic of Cellular pH failure, as the lower pH terrain will always result in slower arrival of nutrient cargo as the Endosomes slow, and the waste removal systems slow affecting C-reactive protein as the paper above reports finding most often. Why would Sodium Bicarbonate, Magnesium Hydoxide and the like (high pH substances) not be a first line defence in these dynamics? I cannot understand why not, but a Doctor I am not!

Why does it affect Afro-Carribeans more? We’ve seen that COVID is seen to affect C-reactive protein in a very high number of cases, what if we overlay Omega 3 to this dynamic?

Relationship of Omega-3 Fatty Acids on C-Reactive Protein and Homocysteine in Haitian and African Americans with and without Type 2 Diabetes

Abstract

Background:

Omega-3 fatty acids (n-3) may be protective of cardiovascular risk factors for vulnerable populations. The purpose of this study was to assess the association between n-3 with, C-reactive protein (CRP), and homocysteine (HCY) in Black minorities with and without type 2 diabetes.

Results:

African Americans had higher waist circumferences and C-reactive protein and consumed more calories as compared to Haitian Americans. Omega 3 fatty acid intake per calorie did not differ between these ethnicities, yet African Americans with low n-3 intake were three times more likely to have high C-reactive protein as compared to their counterparts [OR=3. 32 (1. 11, 9. 26) p=0.031].

Conclusions:

Consumption of n-3 may be protective of cardiovascular risk factors such as C-reactive protein and homocysteine for certain ethnicities. Prospective studies are needed to confirm these results.

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820196/

How about Magnesium, and C-Reactive Protein?

Dietary magnesium and C-reactive protein levels.

CONCLUSIONS:

Most Americans consume magnesium at levels below the RDA. Individuals with intakes below the RDA are more likely to have elevated CRP, which may contribute to cardiovascular disease risk.

https://www.ncbi.nlm.nih.gov/pubmed/15930481

ChooseLife Notes : None of this should be construed as medical advice, or advice at all. this is just my reflections on Biological Ionisation as it relates to our current situation. The science supports that pH is very, very important, I dearly hope readers may understand this and seek to make informed choices. This period has seen a galvanising of my own diet, and my daughters, to ensure if we are infected/injured by the condition classified as COVID19 (et al) our bodies are the least likely to succumb to the worst effects some people suffer sadly.

I wish you all every wellness. May we come through this brighter and with more positive spirit than we had before, my love to you all.

Well Wishes, Rich Fosh

Coronavirus Data and thoughts which led me here = http://chooselife.co.uk/index.php/category/coronavirus/

Gates’ Globalist Vaccine Agenda: A Win-Win for Pharma and Mandatory Vaccination

By Robert F. Kennedy Jr., Chairman, Children’s Health Defense

Vaccines, for Bill Gates, are a strategic philanthropy that feed his many vaccine-related businesses (including Microsoft’s ambition to control a global vaccination ID enterprise) and give him dictatorial control of global health policy.

Gates’ obsession with vaccines seems to be fueled by a conviction to save the world with technology.

Promising his share of $450 million of $1.2 billion to eradicate polio, Gates took control of India’s National Technical Advisory Group on Immunization (NTAGI), which mandated up to 50 doses (Table 1) of polio vaccines through overlapping immunization programs to children before the age of five. Indian doctors blame the Gates campaign for a devastating non-polio acute flaccid paralysis (NPAFP) epidemic that paralyzed 490,000 children beyond expected rates between 2000 and 2017. In 2017, the Indian government dialed back Gates’ vaccine regimen and asked Gates and his vaccine policies to leave India. NPAFP rates dropped precipitously.The most frightening [polio] epidemics in Congo, Afghanistan, and the Philippines are all linked to vaccines.

In 2017, the World Health Organization (WHO) reluctantly admitted that the global explosion in polio is predominantly vaccine strain. The most frightening epidemics in Congo, Afghanistan, and the Philippines, are all linked to vaccines. In fact, by 2018, 70% of global polio cases were vaccine strain.

In 2009, the Gates Foundation funded tests of experimental HPV vaccines, developed by Glaxo Smith Kline (GSK) and Merck, on 23,000 young girls in remote Indian provinces. Approximately 1,200 suffered severe side effects, including autoimmune and fertility disorders. Seven died. Indian government investigations charged that Gates-funded researchers committed pervasive ethical violations: pressuring vulnerable village girls into the trial, bullying parents, forging consent forms, and refusing medical care to the injured girls. The case is now in the country’s Supreme Court.South African newspapers complained, ‘We are guinea pigs for the drug makers.’

In 2010, the Gates Foundation funded a phase 3 trial of GSK’s experimental malaria vaccine, killing 151 African infants and causing serious adverse effects, including paralysis, seizure, and febrile convulsions, to 1,048 of the 5,949 children.

During Gates’ 2002 MenAfriVac campaign in Sub-Saharan Africa, Gates’ operatives forcibly vaccinated thousands of African children against meningitis. Approximately 50 of the 500 children vaccinated developed paralysis. South African newspapers complained, “We are guinea pigs for the drug makers.” Nelson Mandela’s former senior economist, Professor Patrick Bond, describes Gates’ philanthropic practices as “ruthless and immoral.”

In 2010, when Gates committed $10 billion to the WHO, he said  “We must make this the decade of vaccines.” A month later, Gates said in a TED Talk that new vaccines “could reduce population.” And, four years later, in 2014, Kenya’s Catholic Doctors Association accused the WHO of chemically sterilizing millions of unwilling Kenyan women with a  “tetanus” vaccine campaign. Independent labs found a sterility formula in every vaccine tested. After denying the charges, WHO finally admitted it had been developing the sterility vaccines for over a decade.  Similar accusations came from Tanzania, Nicaragua, Mexico, and the Philippines.

A 2017 study (Morgenson et. al. 2017) showed that WHO’s popular DTP vaccine is killing more African children than the diseases it prevents. DTP-vaccinated girls suffered 10x the death rate of children who had not yet received the vaccine. WHO has refused to recall the lethal vaccine, which it forces upon tens of millions of African children annually.[Global public health officials] say he has diverted agency resources to serve his personal philosophy that good health only comes in a syringe.

Global public health advocates around the world accuse Gates of steering WHO’s agenda away from the projects that are proven to curb infectious diseases: clean water, hygiene, nutrition, and economic development. The Gates Foundation spends only about $650 million of its $5 billion dollar budget on these areas. They say he has diverted agency resources to serve his personal philosophy that good health only comes in a syringe.

In addition to using his philanthropy to control WHO, UNICEF, GAVI, and PATH, Gates funds a private pharmaceutical company that manufactures vaccines and is donating $50 million to 12 pharmaceutical companies to speed up development of a coronavirus vaccine. In his recent media appearances, Gates appears confident that the Covid-19 crisis will now give him the opportunity to force his dictatorial vaccine programs on all American children – and adults.

Related :

Chooselife : Would you trust this man, or his form of Philanthropy near your (or your family, friends and society in general) health? No, no I wouldn’t.

pH Vs Coronavirus

Here are some excerpts of a paper on the functioning of Hydroxychloroquine, the drug being touted as a medicine to combat CoronaVirus. It can be seen that it’s major action, supportive of the previous data I’ve presented, is raising pH…

Hydroxychloroquine (HCQ) enters and accumulates in lysosomes along a pH gradientIn lysosomes, hydroxychloroquine inhibits the degradation of cargo derived externally (via endocytosis or phagocytosis) or internally (via the autophagy pathway) in autolysosomes by increasing the pH to prevent the activity of lysosomal enzymes. Inhibition of lysosomal activity can prevent MHC class II-mediated autoantigen presentation. 

Hydroxychloroquine can also accumulate in endosomes and bind to the minor groove of double-stranded DNA. This drug can inhibit Toll-like receptor (TLR) signalling by altering the pH of endosomes (involved in TLR processing) and/or preventing TLR7 and TLR9 from binding their ligands (RNA and DNA, respectively). Hydroxychloroquine can also inhibit the activity of the nucleic acid sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) by interfering with its binding to cytosolic DNA. By preventing TLR signalling and cGAS–stimulator of interferon genes (STING) signalling, hydroxychloroquine can reduce the production of pro-inflammatory cytokines, including type I interferons.

….

As the pH in lysosomes is optimal for lysosomal enzymes involved in hydrolysis, by increasing the pH of endosomal compartments85, chloroquine and hydroxychloroquine might impair the maturation of lysosomes and autophagosomes and inhibit antigen presentation along the lysosomal pathway (Fig. 3).

These processes possibly occur, at least in part, through drug-mediated changes in the pH of autophagosomes and/or lysosomes, which indirectly influence immune activation; however, such a mode of action requires additional validation to aid with future drug development.

https://www.nature.com/articles/s41584-020-0372-x

This is the drug they are saying shows great promise for Coronavirus treatment.

Here is excerpts from a paper just being released, where studies have shown 100% cure rate with CoronaVirus:

He talks about lowering the acidity in the cells…

https://www.covidtrial.io/

From their prelim paper:

Specifically, the CDC research was completed in primate cells using chloroquine’s well known function of elevating endosomal pH. The results show that “We have identified chloroquine as an effective antiviral agent for SARS-CoV in cell culture conditions, as evidenced by its inhibitory effect when the drug was added prior to infection or after the initiation and establishment of infection. The fact that chloroquine exerts an antiviral effect during pre- and postinfection conditions suggest that it is likely to have both prophylactic and therapeutic advantages.

When chloroquine is added after infection, it can rapidly raise the pH and subvert on-going fusion events between virus and endosomes, thus inhibiting the infection. When added after the initiation of infection, it likely affects the endosome-mediated fusion, subsequent virus replication, or assembly and release. Specifically, rapid elevation of endosomal pH and abrogation of virus-endosome fusion may be the primary mechanism by which virus infection is prevented under post-treatment conditions.

Specifically, the virus depends on turning over the host proteins to trigger response for available building blocks to make their own proteins or nucleic acids. They break down due to low PH catalyzed by hydrolysis. 

It is this part of the coronavirus’ replicative path that chloroquine inhibits. Notably, because of its nitrogen structure, chloroquine has the unique ability to get into cells and cross endosomal membranes. Once inside, nitrogens in chloroquine (and quinines in general) prevent acidification by absorbing a high amount of hydrogens that simply then interact with nitrogen and then chloroquine becomes positively charged – an ionic interaction which makes it harder for the endosome to become acidifiedThe result is a buffer that holds it at the higher pH and prevents it from becoming acidic enough to be functional. To summarize, because chloroquine has a multitude of extra nitrogens, once it crosses the membrane and enters an organelle, the organelle is prevented from reaching a lower pH. The organelle’s enzymes cannot work because the donor group will be a hydrogen ion, disabling the hydrolysis required for coronavirus replication. This means that all kinds of events in the cell are incapable of performing optimally, including viral replication.

https://github.com/covidtrial/info/raw/master/An%20Effective%20Treatment%20for%20Coronavirus%20(COVID-19).pdf

Biological Ionisation…

Wonder why I go on and on about pH…

Stunning nobody is talking about Milk Of Magnesia, or other inexpensive pH raising substances…

Related:

Bill Munro Vs The Coronavirus

Bill brought inhalation of H2O2 to the publics attention, he used it 5-6 pumps, 6 or 7x a day. To keep his Oxygen levels high, to keep the Viruses out, which come when Oxygen is down.

This was something I tried many years ago, but didn’t feel a direct or urgent need to do, so put it into my memory locker.

However, after studying this new Viral Epidemic which increasingly surrounds us, I pulled the information back to my short term memory to mix with the pH principles I had been reflecting on.

My daughter has suffered from Chronic Lung Disease as a result of being born at 24weeks gestation, so Oxygen and Viral susceptibility has been something I am used to reflecting deeply upon.

Anyway, the data shows that if you are of a lower pH, this virus group (Corona) is 10x more forceful and you are 10x more susceptible (at a pH of 6 Vs 7), so after ensuring I got my diet plans and supplements into order, I began to reflect over and over how else I can best prepare.

This is when Bill Munro came back to my mind, so I ordered 2x Nasal Vaporiser’s for about £3, and I decided that I would start taking a similar number of rounds of H2O2 as Bill did, but diluted to 1.5% with 50% Distilled water and 50% Food Grade H2O3 at 3%.

The literature for killing the Virus shows that 0.5% H2O2 kills the virus in 1 Minute, so 1.5% should be effective in 20 Seconds or thereabouts. So, to my unqualified mind, this leads me to presume that several rounds of this daily may safeguard me against this threat, if not preventing it from entering my airways entirely, then at least killing it off 5-6 times a day, minimising the intensity of the infection as best I may.

When I have talked of this method to others, peoples minds immediately seem to jump to “you are swallowing bleach”, with a shocked reaction, yet I explain that this is simply water with an extra Oxygen molecule attached, which people regularly treat their teeth with at 7% some 450% stronger than I am using. People seem to not bat an eyelid at using 4.5x stronger bleach for their teeth and vanity, yet to stave of seemingly very harsh virus people react like I am the crazy one!

This method along with Alkalising my terrain via diet and supplements are the best methods I have encountered to protect myself against this horrid viral outbreak.

If the outbreak worsens in the UK, I am intending to upgrade to the full 3%

Thank you Bill.