Wenju Lu, Xiaoqing Liu, Tao Wang, Fei Liu, Airu Zhu, and Yongping Lin
Patients with coronavirus disease 2019 (COVID-19) exhibit a spectrum of respiratory symptoms like cough and dyspnea.1–3 Airway mucus is an adhesive viscoelastic gel composed mostly of high-molecular-weight mucous glycoproteins and water, which is important in maintaining lung function and health, pathological mucus hypersecretion may cause airway obstruction and lead to respiratory distress. Mucin (MUC) glycoproteins are the major macromolecular components of mucus, which are classified into two major types: the gel-forming secreted MUC5AC and the membrane-tethered MUC1.4 Here, with an attempt to understand the lung changes, we sought to provide a delineation of the components of airway mucus from patients with COVID-19.
To clean airway obstruction, respiratory tract mucus was aspirated and collected via bronchoscopy from COVID-19 patients with a critical illness, and optical coherence tomography (OCT) was applied via bronchoscopy to obtain cross-sectional images of the bronchiole. For healthy control, sputum was induced by inhaled hypertonic (3%) saline solution delivered with an ultrasonic nebulizer. After collection, sputum was processed as previously described for components analysis.5 Medical history, and clinical and laboratory data of the participants were extracted from electronic medical records. The study was approved by the Ethics Committee of the First Affiliated Hospital of Guangzhou Medical University (No. 2020-65). The requirement for informed consent was waived because the study was observational and the family members were in quarantine.
MUC5AC (sc-21701; Santa Cruz, Shanghai, China) and MUC1 (sc-6827; Santa Cruz) in airway mucus were measured using enzyme-linked immunosorbent assay, and MUC1-cytoplasmic tail (CT, clone EP1024Y; Abcam, Shanghai) levels were measured by Western blot analysis as described previously.5 The levels of MUC5AC and MUC1 were normalized to their average signal reading of a healthy control group.
A total of 16 patients with COVID-19 were included in this study, the clinical characteristics of the recruited subjects were shown in Table S1. There was no significant deviation in the distribution of age, or sex between the cohorts of case and control subjects. All the patients with COVID-19 were admitted to the intensive care unit because of low oxygenation index (199 ± 23 mm Hg), and 79% of them received mechanical ventilation. Blood laboratory tests showed elevated inflammatory indexes including leukocyte count, C-reactive protein, and interleukin-6 in most of the patients with COVID-19 (Table S2).
OCT indicated clear bronchiole in healthy controls (Figure 1A) and mucus retention in the bronchiole of patients with COVID-19 (Figure 1B). A volume of 1-8 mL white to gray sputum with high viscosity (Figure 1C) was aspirated from the respiratory tract of 16 patients with COVID-19. Induced sputum from healthy control was clear and transparent with low viscosity. Compared to healthy control, airway mucus from patients with COVID-19 had a higher level of MUC5AC (Figure 1D), MUC1 (Figure 1E), and MUC1-CT fragment (Figure 1F). However, there were no significant differences in the concentration of total protein, sodium, or chloride in the airway mucus from patients with COVID-19 when compared to healthy control (Table S3).
Although more than half of patients with COVID-19 presented with a dry cough,6 this study provided direct evidence showing mucus retention in the small airway of patients with COVID-19, and patients were not able to expectorate by themselves and need bronchoscopy aspiration to help them to clean respiratory tract. The sputum from these patients with COVID-19 was viscous, which is not surprising as MUC5AC levels are extremely high, hyperconcentration of this gel-forming MUC dehydrates airway surfaces and causes mucus adhesion, which may contribute to airflow obstruction and respiratory distress. Clearance of airway mucus is an important way to increase oxygen and carbon dioxide exchange, bronchoscopy aspiration of airway mucus was used in all our patients to relieve hypoxia. In our center, all the 16 critical ill COVID-19 patients recovered and were discharged from hospitalization, which may attribute to our aggressive clearance of the respiratory tract. It is of note that bedside bronchoscopy may not be available in some hospitals as the medical resources are limited during the COVID-19 pandemic, carbocisteine has been reported to inhibit airway MUC5AC secretion, which could be used to reduce sputum viscosity and elasticity in patients with COVID-19. In addition, hydration of sputum by aerosolized hypertonic saline solutions or mannitol, and dilation of bronchi via aerosolized salbutamol may facilitate sputum expectoration.
MUC1 is a membrane-tethered MUC expressed on the apical surface of epithelial cells.7, 8 Since MUC1-CT fragment is on the cytoplasmic side of the cells, the elevated sputum CT fragment in patients with COVID-19 could come from detached and disrupted epithelial cells, which is evidenced by the pathological findings of diffuse alveolar damage with fibromyxoid exudates and macrophage infiltration in the lung tissue from patients with COVID-19.9
The limitation of this study is that induced sputum was used in the control group to compare airway mucus aspirated via bronchoscopy from patients with COVID-19, because it was very difficult for the patients with COVID-19 to expectorate sputum even with hypertonic saline solution inhalation.
The findings may suggest that increased level of MUCs in the airway mucus may contribute to the high viscosity of airway mucus and sputum retention in the small airway of patients with COVID-19, airway mucus clearance may be indicated to relieve respiratory distress, and MUC5AC may serve as a target for mucolytic agents in treating COVID-19. And MUC1-CT may serve as an indicator reflecting the severity of airway and alveolar epithelial cell damage.
This study was supported by grants from the National Key R&D Project (2016YFC0903700 and 2016YFC1304102), the National Natural Science Foundation of China (81520108001 and 81770043), and grant specific for COVID-19 study from Guangzhou Institute of Respiratory Health. The authors would like to thank Dr Kwang Chul Kim (University of Arizona) for the invaluable assistance with the manuscript.
CONFLICT OF INTERESTS
The authors declare that there are no conflict of interests.
The Fatty Acid Research Institute (FARI) has published a new research paper in conjunction with The Cooper Institute on omega-3s and heart rate recovery.
Omega-3 fatty acids have a long history of being heart healthy, but exactly why and how has been less clear. They are known to lower serum triglyceride levels, but the effect is relatively small and it’s not clear how much of a risk factor high triglyceride levels is in the first place. So how do the omega-3 fatty acids EPA and DHA work?
A recent study from the Cooper Center Longitudinal Study (CCLS) and FARI sheds new light on this question.
The investigators utilized data from 13,912 healthy men and women who had preventive medical examinations at Cooper Clinic in Dallas over a 10-year period. These examinations routinely included both treadmill exercise testing and measurement of the Omega-3 Index (i.e., red blood cell EPA+DHA levels from OmegaQuant Analytics).
One component of the exercise test is called ‘heart rate recovery’ and it refers to how quickly the heartbeat slows down after maximal exercise. The faster it drops, the healthier the heart.
Comparing each patient’s heart rate recovery with their Omega-3 Index, the researchers found a significant relationship between these two variables such that the higher the Index, the faster the heart rate dropped down. The effect was more marked in women than men, but statistically significant in both. This is summarized in the Figure 1 (right) where the Omega-3 Index is plotted on the x-axis, and the drop in heart rate one minute after stopping the treadmill test (measured in beats per minute, bpm) is shown as a positive number on the y-axis. These are the unadjusted values. (For example, 25 bpm on the y-axis means that 1 minute after stopping exercising—i.e., the maximal heart rate—the person’s heart rate dropped by 25 bpm).
When adjusted for age, maximal METS (a measure of cardiorespiratory fitness), BMI and smoking status, a 2-percentage point higher Omega-3 Index was associated with a 0.35 and 0.69 bpm greater heart rate recovery in men and women, respectively (p<0.001 both).
Previous studies have shown that a slow heart rate recovery is associated with increased risk for sudden cardiac death, which fits with higher EPA and DHA levels being linked with reduced risk for sudden cardiac death3.
Dr. William Harris, President of FARI and co-inventor of the Omega-3 Index, who was also an author on the study, commented on the implications of this research. “These new findings from the CCLS harmonize with the known benefits of omega-3 fatty acids on resting heart rate and provide new clues to how these important fatty acids can preserve cardiac health,” he said.
“These benefits on cardiac autonomic tone join other cardioprotective effects of omega-3 fatty acids, including the reduction in blood pressure, chronic inflammation and platelet aggregation, to at least partially explain why omega-3s are good for the heart. Future treatment studies should define the omega-3 intake (and Omega-3 Index) that optimizes this aspect of cardiac function.”
Dr. James H O’Keefe, MD, a cardiologist and Medical Director of the Charles and Barbara Duboc Cardio Health & Wellness Center at Saint Luke’s Mid America Heart
Institute in Kansas City, MO, and a Professor of Medicine at the University of Missouri-Kansas City (who was not involved with the study) remarked that this research provides “strong data supporting the robust cardiovascular benefits of omega-3 fatty acids.”
Mucus plays a pivotal role in protecting the respiratory tract against microbial infections. It acts as a primary contact site to entrap microbes and facilitates their removal from the respiratory tract via the coordinated beating of motile cilia. The major components of airway mucus are heavily O-glycosylated mucin glycoproteins, divided into gel-forming mucins and transmembrane mucins. The gel-forming mucins MUC5AC and MUC5B are the primary structural components of airway mucus, and they enable efficient clearance of pathogens by mucociliary clearance. MUC5B is constitutively expressed in the healthy airway, whereas MUC5AC is upregulated in response to inflammatory challenge. MUC1, MUC4, and MUC16 are the three major transmembrane mucins of the respiratory tracts which prevent microbial invasion, can act as releasable decoy receptors, and activate intracellular signal transduction pathways. Pathogens have evolved virulence factors such as adhesins that facilitate interaction with specific mucins and mucin glycans, for example, terminal sialic acids. Mucin expression and glycosylation are dependent on the inflammatory state of the respiratory tract and are directly regulated by proinflammatory cytokines and microbial ligands. Gender and age also impact mucin glycosylation and expression through the female sex hormone estradiol and age-related downregulation of mucin production. Here, we discuss what is currently known about the role of respiratory mucins and their glycans during bacterial and viral infections of the airways and their relevance for the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Understanding the impact of microbe-mucin interaction in the respiratory tract could inspire the development of novel therapies to boost mucosal defense and combat respiratory infections.
(b. Torsaker, Sweden, 30 June 1873; d. Lund, Sweden, 4 December 1952)
The son of Per Erik Thunberg, a merchant, and of Wendela Maria Elisabeth Hård, Thunberg studied medicine at the University of Uppsala from 1891 to 1900 and obtained the M.D. degree with a dissertation on epidermal sensory perception. He was demonstrator for Olof Hammarsten at the Institute of Physiological Chemistry in 1893–1894 and for Frithiof Holmgren at the Institute of Physiology at Uppsala in 1894–1896. He was reader in physiology at Uppsala in 1897–1904. Immediately after the death of Magnus Blix in 1904, Thunberg went to Lund as temporary occupant of the chair of physiology and embryology; the following year he was appointed to the chair of physiology, from which he retired in 1938.
Thunbergs first work, on sensory physiology, was published in 1893 and his last, in 1953. Thunberg extensively studied the physiology of epidermal sensations, showing, among other things, that a pinprick gives rise to two sensations of pain, the second occurring some seconds after the first. This phenomenon was interpreted much later by Zotter-man, who demonstrated the existence of two groups of pain fibers, one of which transmits impulses more slowly than the other. In 1905 Thunberg wrote the chapter “Physiologie der Druck-, Temperatur- und Schmerzempfindungen” for Nagel’s Handhuch der Physiologie des Menschen. With this work he left a field into which he had been led more by chance than by ability.
In 1903, when Thunberg began to study the elementary processes of metabolism–studies that constitute his major contributions to science–nothing was known of the oxidation processes in the tissue cells. Energy is derived in the cells by combustion (cellular respiration), whereby oxygen is consumed and carbon dioxide produced. Lavoisier had proved that respiration is chemically a combustion process in the 1770’s. From then until 1875, the consumption of oxygen and the production of carbon dioxide were thought to be confined to the lungs and the blood. In that year Pflüger proclaimed: “Cells are constantly burning, although we do not see their light with our weak vision.” Everyday experience shows that organic material does not burn in oxygen at body temperature, so it was assumed that oxygen was activated in some way. From about 1840 a series of oxygen activation theories appeared: but valid knowledge had to await the work of Thunberg, Otto Warburg, and Heinrich Wieland. Warburg introduced the term Atmungsferment and argued that this enzyme that catalyzed oxidation was an iron-pyrrole complex. His idea was based on the orthodox concept that the degradation and combustion of food to carbon dioxide and water took place through the direct attack of oxygen on the carbon atoms of the food. Thunberg and Wieland developed an entirely new conception, rivaling that of Warburg.
In 1908 Thunberg began to study the capacity of cells to burn various organic acids, including acetic, propionic, oxalic, malic, succinic, and citric. These acids were not then recognized as normal constituents of the body that played a role in intracellular metabolism; rather, they were known as products of putrefaction or fermentation. From among all the organic acids Thunberg chose precisely those that proved useful to his aims, thus revealing his unerring sense for the right path to follow.
Wieland turned to this area of investigation just when his cooperation was needed to elucidate the nature of the processes of biological oxidation. In 1912 he found that organic compounds can be oxidized through removal of hydrogen in the presence of a catalyst and that the hydrogen can be taken up by suitable acceptors, such as methylene blue. From 1910 Thunberg integrated Wieland’s discoveries with his own, especially those on the biological oxidation of succinate, and initiated the concept of the specific, hydrogen-activating, chain-forming enzyme systems. When Thunberg began this work, all that was known of intracellular enzymes was merely that postmortem autolysis was catalyzed by proteolytic enzymes. Oxidases also had been found.
Thunberg saw that the oxidation of succinate was initiated by an agent in the cells that endowed a hydrogen group in the succinate with a reactivity that it had not previously possessed. The reactivity could easily be demonstrated with methylene blue, which was decolorized by hydrogen uptake. Under the influence of this agent in the cells, the succinate emerged as “hydrogen donator” and released a hydrogen group to the “hydrogen acceptor” methylene blue. The terms “donator” and “acceptor” were introduced by Thunberg and are now in general use. He called the enzymatic agent a dehydrogenase, in this case succinate dehydrogenase. The introduction of the methylene blue method in 1916 opened up a worldwide search for dehydrogenases. The chainlike degradation of the various organic molecules in the organism could now be charted.
Thunberg finally formulated the following generalization concerning the oxidative degradation of food: the degradation is accomplished by a chain of consecutive splittings of hydrogen atoms carried out by a series of dehydrogenases, each with a specific purpose.
With the discovery of a hydrogen-carrying flavo-protein, das gelbe Atmungsferment, Warburg in 1932 contributed substantially to Thunberg’s conception of hydrogen transport from one system to another as a central mechanism in oxidative metabolism. Thunberg rightfully considered himself responsible for a revolution in the concept of the mechanism of biological oxidation.
In 1905, the year of his appointment to the chair of physiology at Lund, Thunberg recorded that nerve tissue respires, taking up oxygen and giving up carbon dioxide. It had previously been thought that nerve fibers conducted impulses like an electric cable, without measurable energy consumption. Thunberg made this discovery with his micro-respirometer, an ingenious device with which he could measure oxygen consumption and carbon dioxide production in small units of tissue. Using this apparatus, he also could demonstrate that traces of certain metals, such as manganese salts, strongly catalyze tissue respiration. This field held his interest throughout his retirement.
Although a scientist first, Thunberg was not unfamiliar with the nonscientific world. As a student at Uppsala he was associated with the radical-liberal group Verdandis, headed by the physiologist Hjalmar Öhrvall. During five decades– through books, popular journals, pamphlets, and the daily press, and as an adviser to the government–he disseminated information on hygiene and medicine that in scope and quality was unparalleled in Sweden.
Thunberg’s enormous capacity for work was combined with good health, and he reached the age of seventy before becoming seriously ill, with pneumonia, from which he recovered. He was fully active for more than nine years, until October 1952, when he stumbled over the doorstep of his house and broke his femur. Despite the best care, he died early in December. He had been elected a member of the Royal Swedish Academy of Sciences in 1928, and later of many foreign learned societies.
Obituaries include Georg Kahlson, “Thorsten Thunberg.” in Acta physiologica scandinavica, 30 (1953), supp. 1ll: and F. G. Young, “Prof. T. Thunberg,” in Nature (12 Dec. 1953).
These are steps, which if taken, may help recovery of the bodies abilities to utilise it’s elegant recovery mechanisms, to an elite level, relative to that which constrains us (age, history…).
1. First, the cornerstone for me:
Studies have shown, that Omega3 in various forms (Here is just a few days of searching the published medical papers for Flax), has a juggernaut of healing potential based in and around it.
My day, usually starts with 125g of Kefir Quark (called Kefir Protein in both Waitrose and M&S), blended with 62.5g of super fresh (very important as we’re dealing with Oxidation here) Flaxoil.
Above Picture, is when the Flaxoil is high lignan, if not the high lignan oil; then to be an official Budwig Breakfast, it should have freshly blended flax seeds.
This is blended with a hand blender, or whisk. Then I eat one spoonful alone, before having the rest with low glycemic fruit (Strawberries are my youngest daughters choice, Raspberries my eldest). Sometimes (almost always), I also have with this Planet Organic Paleo Vegan Granola:
Though this is not strictly Budwig kosher, if issues with Cancer or major illness I would not have this element personally.
This above step 1 is my absolute cornerstone with regards to fat metabolism, and protein intake, the sulfur rich proteins in the Kefir Quark has a natural affinity with the Flaxoil, which when blended make them water soluble, emulsify it to give a huge surface area, relative to having it just as an oil, a gestalt food where the sum exceeds the constituents hugely.
This is the foundation of Johanna Budwig’s research (the blend, forget the Granola), which she reported is the best was to re-ignite the Cell walls ability to take and carry Oxygen = Prevention of (or recovery from) Respiratory Acidosis.
2. Green Smoothies – This is a two form deal. Firstly, to explain; the greens in leaves n vegetables etc. Are very rich in Chlorophylls, the centre of which is Magnesium:
So, as we can see, as well as the Magnesium boost you get, you also get a pre-constructed shell your body can use to apply Iron and you have Hemoglobin, then you have the folates, the VitaminK (which microbes in your body may convert to K2 if you eat correctly) and on and on.
When studying diet types, it became clear that green smoothies, with some oil as much of the goodness is fat soluble, creates a sensational dynamic for our Liver/Pancreas/Digestion/Well-Being.
How many of us can truly say we eat enough greens?
So, at least once a day, lately, I am trying to have the following:
1/3-1/4 Bag of Organic mixed leaves (M&S is my choice here) 1/3 Cucumber 1/3 Avocado 1 Tsp of Norwegian Kelp (Ascophyllum nodosum) 1 TBSP Flaxoil or Cold Pressed Organic Olive Oil 1 Small pinch of Epsom Salts 1 Tsp of Limewater or Calcium powder (I favour Min-Col, or, Cal II) 1 Handful of low Glycemic Fruit (Cherries today, very nice) 1 1/4 Lemon juice
Fill almost to top with clean water (I’ve got a distiller, but otherwise I like Evian, or Buxton is low Nitrate, Volvic is Silica rich and good if you have memory concerns), blend, and drink.
If no Lemon to hand, Apple Cider Vinegar, Raw with Mother, is an OK substitute, but Lemon is best IMO.
(Reams said the leaves and Olive Oil creates a gelatinous like substance to help lubricate our bowels, he advocated only a salad with olive oil for dinner, low late day protein to rest the body/liver/digestion and set yourself up for the following day, but this is a tough lifestyle adjustment to make, but dovetails research showing the autonomic nervous system needs to direct it’s juice to the Adrenals, key time 11pm-1am I believe, so it must be best to finish digesting proteins which take considerable oxygen, so it may direct it at your innate rest and repair cycles, such as recovering the adrenals, crucial in todays high processed, high refined, world)
3. Moreless Alkalising Drink:
1TBSP Limewater (This is Pickling Lime, but not sold in UK so make my own*) 1 TSP of Raw Honey (Organic, away from high pesticide areas), otherwise Unsulphured Molasses 3 TBSP Norwegian Kelp Powder 1 TBSP Apple Pectin 1/2 Cup Water 1/2 Juice Fresh Lemon 1 Pinch Epsom Salts
* This is made from Calcium Hydroxide, please understand not the powder itself, learn the method carefully, if not I have used Min-Col, Call II from Daily Manufacturing which are based on Reams teachings. Be Careful with Calcium!
Mix well, usually I mix this, except the lemon, leave it for an hour or two for the kelp and honey/molasses to fully mix easily, then juice in the lemon when I am to start sipping it. This is a high alkaline, and it is designed to be sipped upon hourly, to prop up your body (it’s well shown that most yeasts/viruses/bacteria/fungus of harmful nature are attracted to, and thrive, in more acidic terrain, mine runs acidic, my daughters when tested does, so this scales up as I see any of the multitude of signs for heightened acidity, in myself or my Girls, though my youngest rejects the Kelp as Yucky, but is fine with it without).
This above Alkaline mix, is the foundation of work, based upon studies of Biological Ionisation, which averts or prevents bodies which flirt with Metabolic Acidosis, Moreless would repeatedly say listen to your body and adjust up/down each ingredient, he rightly for his biochemistry expounded the virtues of all the trace minerals in Molasses, but I cannot tolerate that energetically so I use high, high quality raw organic honey, just enough to carry the Calciums and give a live Carbon bond to the otherwise slightly toxic hydroxide.
These are my foundations of well-being, on top of this, I try to eat as much fresh vegetables as I can. If we get to the stage that we are eating 50% raw fruit and vegetables (mainly veg, and low glycemic fruits), then we are giving such a rest to our Liver.
The above is a large part of the cornerstone of a diet, which if applied correctly, may help almost any illness, it is the foundational elements that the degradation of soil vitality and increasingly denatured living deprive us.
Understand what health is and what it means. Understand levels of body chemistry using urine and saliva. Understand the proper relationship of mental and spiritual aspects of health relating to body chemistry.
Throughout his research, Dr. Reams discovered that only two bodily fluids were needed to show your body chemistry levels – saliva and urine. If a person keeps his numbers in the Perfect Health or Healing range – it is believed the human body will maintain health. If the human body in not kept in the Perfect Health or in the Healing range – it is believed the body becomes diseased. The great news in pH testing is that you can manipulate your balances by controlling what you put into your body.
REAMS testing, this is how it works.
¬ The Carbohydrate measurement is made with a refractometer and it measures the number of brix in a urine specimen. It also represents the amount of potential energy available per pound of body weight. The ideal carbohydrate measure is 1.5 brix. Healing range is 1.2-2.0 brix. Below 1.2 represents low blood sugar. 5.5 and above represents borderline diabetes.
¬ The pH is a measurement of resistance and indicates the speed at which energy is moving through the body. A reading of 6.4 is the ideal speed for energy to move through the body. The pH is written as a fraction. The top number is the urine pH and the bottom number is the saliva pH. Healing range is 6.2-6.6. If you add the urine pH number to two times the saliva pH number and divide by three – the results will yield your average bodily pH. This is helpful in analyzing the direction of the overall pH of your body. Urine pH provides information about the blood, saliva pH provides information about the liver.
¬ The Salt or conductivity reading is ideally 6-7C. The conductivity number indicates the level of salts in the body. The salt number indicates whether the body has the correct number of electrolytes. Electrolyte levels indicate whether the body is undercharging or overcharging.
¬ Cell debris is an indication of the number of dead cells leaving the body. A sick body needs to rid itself of excess dead cells. The ideal cell debris number is .04M. The cell debris number tells how well the body is cooperating in the healing process. It is also the last number to come into balance.
¬ Urea readings are the Ammonia Nitrates and the Nitrate Nitrates added together. They equal the total ureas. Total ureas represent the total amount of unutilized protein that is being handled by the liver and sent to the kidneys for elimination.
¬ Cell Exchange Rate – Ultimately the entire body chemistry depends upon the correct cell exchange rate. Homeostasis – a new healthy cell is produced for each old cell dying off. If any of the numbers are off, the cell exchange rate is off and cells are not getting produced to maintain homeostasis. There are three classes of cells: Alpha Cells – perfect whole cells, Delta Cells – damaged or dead cells ready to be replaced, and Omega Cells – dead cells clumping and sticking together. Good health demands an even exchange rate – dead cells out and new cells in. If any of the numbers in the equation are out of range then the delta cells are not leaving the body. Any time the cell exchange is off, there is a mineral problem in the body. The body is made of minerals…The dust of the earth…Minerals are the basis for good health…You cannot build healthy cells without minerals.
¬ Mineral Assimilation is determined by the pH of the digestive system. A second issue is the atomic number of each of the minerals. The higher the frequency, the more difficult it is to assimilate the particular mineral.
What does this test reveal? Determines calcium needs for your body chemistry Tells what you are digesting or not digesting Tells if your body is assimilating nutrients Shows vitamin and mineral deficiencies Reveals if blood sugar is high, low or normal Will show if your body is supporting excess yeast candidiasis) or parasites Indicates if there is excess stress on internal organs such as the kidneys, liver, heart, colon or gall bladder Gives the health level of the liver and gall bladder Reveals if your body’s environment may be supporting: circulatory problems high blood pressure low blood pressure arthritis weight gain high cholesterol kidney/gall stones
PERFECT NUMBERS Through extensive research, Dr. Carey Reams discovered the “perfect numbers” for Biological Ionization, which represent the ideal cellular resistance required for life, just as 98.6 degrees represents the perfect resistance (temperature) for a healthy body. The higher the resistance, the higher the temperature. The lower the resistance, the colder the temperature. Death may occur from either extreme.
ENERGY FROM FOOD We do not live off the food we eat but off the energy produced by the food we eat. It is believed that we receive approximately 20% of our mineral energy from this digestive principal. Approximately 80% comes from the atmosphere. The more efficient the digestion, the more efficient the body is in extracting mineral energy from the air.
PREMATURE AGING Resistance is required for life. An excess of resistance can result in disease and death. Likewise, a deficiency of resistance can also result in disease and death. Dr. Reams determined that each of the 7 parameters, when all occurring simultaneously, represents the perfect 100% Metabolism Efficiency (the conversion of food into energy). The theory being that, if one could maintain a lifestyle that continually manifested the “perfect numbers”, there would be no premature aging.
BIOLOGICAL IONIZATION Of course there is no such perfect world, hence aging does occur. The objective, using “Reams Testing” as a guide, is to determine the proper lifestyle that allows a person to age, but not prematurely age. As the metabolism efficiency decreases, premature aging is more likely to occur, predisposing one to the disease process. How are urine and saliva tests different than a blood test? According to Dr. Reams, the blood changes every 15 minutes. The urine and saliva test was found to be more accurate. The testing of these two substances is amazingly accurate in determining the degree of wellness one might be experiencing and importantly what minerals, vitamins, and foods one should or should not eat. Biological Ionization Analysis is an excellent metabolic biofeedback device to indicate whether a particular lifestyle is beneficial or detrimental for any individual. It gives specific information on what vitamins and minerals are not being assimilated into the body’s cellular structure. It provides biofeedback on a holistic (emotional, physical, spiritual) level.
By Donald Kraus (Reams Practitioner) : http://www.bodylifedirect.com/
This is a ramble, of the threads of thought which are on my mind. In time this may be edited and streamlined, but presently I feel it paints a picture that may help others. It is clear something deep is happening in the world, bigger than just COVID in my opinion. So it will start with a long article about using H2O2 and wander on from there.
Surviving the Coronavirus Disease, How Hydrogen Peroxide Works
Hydrogen Peroxide Has a Long History of Medical Use
Hydrogen peroxide (H2O2) consists of a water molecule (H2O) with an extra oxygen atom.
The oxygen inactivates viral pathogens by breaking down the viral structure
Additionally, our immune cells produce hydrogen peroxide. This is in part how your immune system kills infected cells. Hydrogen peroxide therapy aids aids immune cells to perform their natural function more effectively.
H202 is on the shelf at the local grocery or drug store for $1.00 a bottle.
The Big Q: Can an inexpensive and easy to administer at-home treatment treat the novel coronavirus, SARS-CoV-2?
The Big A: Dr. Thomas Levy says Yes. The remedy is hydrogen peroxide H202, aerosolized in any standard nebulizer.
It’s worth keeping in mind that while the elderly and those with underlying medical conditions are at increased risk of serious complications and death, the overall mortality rate of COVID-19 is quite low, and very similar to the flu.
A compilation of reported mortality statistics from around the world can be found in the paper,“Likelihood of Survival of Coronavirus Disease 2019,” published in The Lancet Infectious Diseases, 30 March 2020.
For the latest up to the min COVID-19 resources click here.
To perform this treatment, you need but two items: a nebulizer with a face mask that covers your mouth and nose that emits a fine mist, and common household 3% hydrogen peroxide, available at most grocery stores and pharmacies for less than $1.
However, you may choose to purchase the more expensive food grade hydrogen peroxide as it doesn’t have any stabilizers in it. Stabilizers are proprietary and companies do not need to disclose them on the label, but some can be problematic.
Typically food grade peroxide comes in concentrations higher than 3% so if you chose it your will need to dilute it down to 3% to use it.
Viruses are not “alive” they need a live host in which they can infect live cells that then replicate the viral DNA and RNA. Once a cell is infected, newly replicated viruses exit the cell and move on to the next cell to duplicate the process.
So, when they talk about “killing” a virus, they are talking about inactivating them by breaking down their structure. This is why soap works so well. Coronaviruses are held together by a lipid (fatty) coating. Soap, being amphipathic, meaning it can dissolve most molecules dissolves this fat membrane, causing the virus to fall apart and become harmless.
More specifically, the fat-like substances in soap are structurally similar to the lipids found in the virus membrane, so the soap molecules compete with and replace the fats in the membrane. In so doing, the “fatty glue” holding the virus together dissolves.
Hydrogen peroxide works in a similar way. As noted by Dr. Levy, “the way to control any viral infection is not to kill the virus; rather, the infected cells that have been turned into viral factories must be killed.”
Our immune cells actually produce hydrogen peroxide. This is in part how the immune system kills cells that have been infected with a virus. By killing the infected cell, viral reproduction is stopped. So, hydrogen peroxide therapy is in essence only aiding our immune cells to perform their natural function more effectively.
Hydrogen peroxide is also a Key redox signaling agent.
“At the low physiological levels in the nanomolar range, H2O2 is the major agent signaling through specific protein targets, which engage in metabolic regulation and stress responses to support cellular adaptation to a changing environment and stress …
Recent methodological advances permit the assessment of molecular interactions of specific ROS [reactive oxygen species] molecules with specific targets in redox signaling pathways.
Accordingly, major advances have occurred in understanding the role of these oxidants in physiology and disease, including the nervous, cardiovascular and immune systems, skeletal muscle and metabolic regulation as well as ageing and cancer.
In the past, unspecific elimination of ROS by use of low molecular mass antioxidant compounds was not successful in counteracting disease initiation and progression in clinical trials. However, controlling specific ROS-mediated signaling pathways by selective targeting offers a perspective for a future of more refined redox medicine.”
In short, hydrogen peroxide is a major ROS, but while ROS are typically thought of as “all bad,” this is a gross oversimplification.
As noted: “Steady-state physiological flux of H2O2 to specific protein targets leads to reversible oxidation, thereby altering protein activity, localization and interactions, which contributes to orchestration of various processes in cells and organs, including cell proliferation, differentiation, migration and angiogenesis. This state of low-level H2O2 maintenance and its associated physiological redox signaling is called ‘oxidative eustress.’”
Contrary to oxidative stress or oxidative distress, oxidative eustress denotes an oxidative challenge that has positive or beneficial effects and is essential in redox signaling.
The Studies: What they tells us
The most relevant study is 1 that was done earlier this year in the Journal of Hospital Infection. They studies 0.5% hydrogen peroxide, 6X weaker than the 3% typically used, and found that it killed human coronaviruses and SARS corona viruses and MERS.
Another study, published in the American Journal of Infection Control in Y 2009, assessed the efficacy of vaporized hydrogen peroxide against viruses on various surfaces, finding exposure to hydrogen peroxide vapor at a concentration of 10 parts per million resulted in 99% inactivation after 2.5 mins.
And a Y 2014 study in the Journal of Hospital Infection found hydrogen peroxide vapor eliminated an array of viruses on stainless steel, including human adenovirus 1, transmissible gastroenteritis coronavirus of pigs (TGEV, a SARS-CoV surrogate), avian influenza virus and swine influenza virus.
According to the authors, “Hydrogen peroxide vapor was virucidal against feline calicivirus, adenovirus, TGEV and avian influenza virus at the lowest vaporized volume tested (25 mL).” Vaporized hydrogen peroxide was found to completely inactivate a range of exotic animal viruses in a Y 1997 study as well.
Hydrogen peroxide’s ability to inactivate dangerous infectious viruses has also been highlighted in vaccine science. As noted in a Y 2016 study in the Vaccine journal, 3% hydrogen peroxide completely and irreversibly inactivated the rabies virus within 2 hrs, thus reducing time and cost of the inactivation process required for the making of a rabies vaccine, which contains inactivated rabies virus.
The most convenient to receive H202 is to inhale its mist, using a nebulizer a small, handheld device that converts liquid into a very fine mist.
The microscopic mist, similar to smoke or vapor, can be comfortably inhaled deep into the nostrils, sinuses and lungs. While nebulizers have routinely been used by asthmatics to deliver medication into their lungs, this delivery system affects not only the lungs but your entire body.
As noted in the Y 2002 review article, “Pulmonary Drug Delivery Systems: Recent Developments and Prospects,” “Targeting drug delivery into the lungs has become one of the most important aspects of systemic … drug delivery systems.“
In the case of respiratory infections, the nebulizer has the added advantage of delivering the hydrogen peroxide right to the areas most affected by respiratory viruses: the sinuses, throat, bronchial tract and lungs.
Dr. Levy writes: “Effective hydrogen peroxide nebulization quite literally, ‘chops the head off of the snake,’ and the virus present elsewhere in the body can then readily be mopped up when the new virus influx has been terminated,”
It should be kept in mind that hydrogen peroxide kills pathogens very readily upon contact in an open wound. It should, therefore, be understandable why putting a fine mist of hydrogen peroxide in all the areas of maximal viral replication promptly puts the body on a pathway to rapid healing.”
Hydrogen Peroxide Protocol
To prevent an infection from taking hold, begin treatment at 1st signs of symptoms. Commercially available 3% hydrogen peroxide is fine for this purpose, and can be used without dilution.
If the undiluted solution stings or burns your nose, you can dilute it up to 50% with pure water. Even lower concentrations can be used, although the antiviral effects will be reduced at lower concentrations.
If already presenting with runny nose or sore throat, Dr. Levy recommends using the nebulizer for 10 to 15 mins 4X a day until the symptoms are relieved. You can also nebulized hydrogen peroxide for prevention and maintenance, which may be advisable during flu season, or while the COVID-19 pandemic is in full swing.
He notes: “As it is a completely non-toxic therapy, nebulization can be administered as often as desired. If done on a daily basis at least once, a very positive impact on bowel and gut function will often be realized as killing the chronic pathogen colonization present in most noses and throats stops the 24/7 swallowing of these pathogens and their associated toxins.
If daily prevention is not a practical option, the effectiveness of this treatment is optimized when somebody sneezes in your face or you finally get off of the plane after a trans-Atlantic flight. Do not wait for initial symptoms. Just nebulize at your 1st opportunity.”
The Dr is bullish in his convictions, however there are associated risks to taking H2O2, perhaps mild or moderate, but they should be discussed, to best inform the reader.
Oxidative Stress may lead to the following :
Oxygen is crucial to life; however, when we use oxygen our bodies constantly produce free radicals. Free radicals are chemically unstable molecules or atoms. They also make other molecules or atoms in the body very unstable, thus damaging proteins, cell membranes, and even DNA structure. This is a process which can lead to permanent damage to cells and tissues resulting in infection, mental decline, depressed immunity system, joint disease, and heart disease. Free radicals are also considered to play an important role in the aging process.
Catalase is constantly in battle against the effect of free radicals to the body. It transforms harmful superoxide radicals into hydrogen peroxide which later breaks down into water and oxygen.
The enzyme Catalase is a key buffer for these dangers, Grey hair may be an indication of inhibited (or low) Catalase production, here are Vegetarian/Vegan food sources:
Vegetarian Sources of Catalase
Written by Don Amerman
Catalase — found throughout nature in the cells of organisms that grow in the presence of oxygen — is an enzyme with potent antioxidant properties. The enzyme facilitates the breakdown of hydrogen peroxide into its harmless components — water and oxygen. Without catalase, the hydrogen peroxide that your body produces during the metabolic process would build up to toxic levels. Catalase occurs naturally in a wide array of plant-based foods, ensuring its availability to vegetarians and vegans.
Age-Related Decline in Catalase
The cells in your body can produce catalase as well as other antioxidant enzymes, such as glutathione peroxidase and superoxide dismutase, or SOD. These enzymes help to neutralize free radicals, according to the authors of “Biology: A Human Emphasis.” Free radicals are atoms or molecules with unpaired electrons that are the byproduct of human biological reactions such as metabolism. Scientists cite free radicals as causative factors in disease and aging-related cell damage. As you age, your body gradually produces less catalase, which results in a buildup of free radicals and an increase in the damage they can cause. To help supplement your body’s declining output of catalase, consume foods that are rich in this vital enzyme.
Garlic, Onions and Their Kin
Nutritionists give members of the allium plant family, which encompasses garlic, leeks, onions and shallots, high praise for their antioxidant properties. Among the cellular antioxidants naturally occurring in allium vegetables is catalase. In a study related to the catalase in allium family members, a team of Hungarian and Romanian researchers evaluated the effects of water stress on the level and activity of catalase and other antioxidant enzymes in these plants. They found that allium plants subjected to water deprivation had increased catalase levels and activity, according to an article published in a 2007 issue of “Plant, Soil and Environment.”
Cruciferous vegetables, including broccoli, cabbage, kale and collard and turnip greens, are rich in catalase. Eating plenty of these green leafy vegetables also stimulates your body’s production of catalase. Researchers at Alabama A&M University conducted an animal study to determine what, if any, anticancer effects could be observed in laboratory rats that were fed a diet of these vegetables. As part of this study, they measured the level of catalase in test animals and found that those fed cruciferous vegetables had sharply higher amounts of catalase in their livers than those animals that were not fed these vegetables. Results of this study were published in a 2012 issue of “International Journal of Cancer Research.”
Wheat sprouts contain high levels of catalase, according to a study by molecular biology researchers at Italy’s University of Perugia. In an article published in the July 2004 issue of the “Journal of Clinical Gastroenterology,” they note that the antioxidant activity of catalase and peroxidase in wheat sprouts is extremely strong. Other vegetarian sources of catalase include apricots, avocados, carrots, cherries, cucumbers, parsnips, potatoes, radishes, spinach and zucchini.
ChooseLife : Parallel to this, is the issues reported of bronchial constriction. This would lead to the thinking that Magnesium Sulphate may be a solid companion to H2O2.
Effect of magnesium sulfate on bronchoconstriction in the lung periphery.
Magnesium sulfate has been shown to be effective clinically as a bronchodilator, but its mechanism of action is unknown. We used a wedged bronchoscope technique to study the ability of MgSO4 at clinically relevant concentrations to attenuate hypocapnia-, acetylcholine- (ACh), and dry air-induced bronchoconstriction in the canine lung periphery. Control experiments demonstrated that consecutive challenges of either hypocapnia or ACh resulted in greater collateral system resistance (Rcs) after the second challenge compared with the first. Intravenous infusion of MgSO4 diminished the maximum response to a second hypocapnic challenge (Rcs = 1.59 +/- 0.29 cmH2O.ml-1.s prechallenge vs. 1.12 +/- 0.20 postchallenge) but had no effect on either ACh- or dry air-induced bronchoconstriction. Serum magnesium levels before MgSO4 administration were 1.59 +/- 0.04 meq/l and rose to 6.20 +/- 0.13 during the infusion. Previous studies demonstrated that nifedipine, like MgSO4 in this study, attenuates hypocapnia-induced bronchoconstriction in the canine lung periphery but has no effect on ACh- or dry air-induced bronchoconstriction. We conclude that these results are consistent with the idea that, like nifedipine, magnesium acts in the airway as a voltage-sensitive calcium channel blocker.
[QUOTE]FAD can exist in four different redox states, which are the flavin-N(5)-oxide, quinone, semiquinone, and hydroquinone. FAD is converted between these states by accepting or donating electrons. FAD, in its fully oxidized form, or quinone form, accepts two electrons and two protons to become FADH22 (hydroquinone form). The semiquinone (FADH) can be formed by either reduction of FAD or oxidation of FADH22 by accepting or donating one electron and one proton, respectively.[/QUOTE]
“Chloroquine was shown to inhibit quinone reductase 2 , a structural neighbour of UDP-N-acetylglucosamine 2-epimerases that are involved in the biosynthesis of sialic acids. The sialic acids are acidic monosaccharides found at the extremity of sugar chains present on cell”
ChooseLife : This links together the researchers and testing of hydroxychloroquine. Is this not an Electron cascade crisis? Or a pH crisis which manifests into/from Electron deficiency? Whether this is from a Virus, or 5G, the results are the same, the treatments are the same in need… Though the overlap in effects from the Virus and the reported dangers of 5G are startling, to say the least. It is no wonder getting sunlight, or Vitamin D (Protons) is postulated often as a key player in this illness crisis.
This would make sense that Zinc with chloroquine is showing great promise in tests, as Zinc again is an Electron donor, like Magnesium…
Here it is worth also noting that Johanna Budwig contributed huge research and understanding of Electron dynamics, and stated very vigorously that it is Flax Seeds which have the highest level of Electron surplus, she found in her research that taking high levels of Flaxseed Oil, mixed with Quark (1 part Flaxseed Oil, 2 parts Quark, making it water soluble) was the most efficient mechanism possible to re-invogorate the human ‘Electron Cloud’
I often take very sick cancer patients away from hospital where they are said to have only a few days left to live, or perhaps only a few hours. This is mostly accompanied by very good results. The very first thing which these patients and their families tell me is that, in the hospital, it was said that they could no longer urinate or produce bowel movements. They suffered from dry coughing without being able to bring up any mucous.
Every- thing was blocked. It greatly encourages them when suddenly, in all these symptoms, the surface-active fats with their wealth of electrons, start reactivating the vital functions and the patient immediately begins to feel better. It is very interesting to ask how this sudden change is possible. It has to do with the reaction patterns, with the character of electrons. I will return to these electrons later. In the last two years I have come to be very fond of them. A friend of my work in Paris wrote to me how wonderful it is that you have discovered the original birthplace of the electrons in seed oils to be the sun. That’s how these connections are made!
ChooseLife : As soon as I heard about COVID, and the chief symptom of dry cough, I though about the Budwig book and that paragraph above shouted at me. Flax (ALA) I knew was a key supportive element, yet at that stage I did not see the larger context.
Further to this, a new to air youtuber – Ava Green, has become viral, after relating her experiences with Diamox and the alignment of it’s usage and the COVID symptoms : Almost High Altitude Sickness
Pulmonary Edema, Diamox (acetylzolamide) increases Urine pH, relieving this issue:
However, Pulmonary Edema is usually characterised as symptomatic of ‘Productive Cough’ or ‘Wet Cough’ not ‘Dry Cough’. Countless reports I have seen suggest quite the opposite, that the pneumonia/illness type is a very sticky mucus laiden lungs when scanned, hence a dry cough.
This form of eating 75% Fruit and Vegetables, with a strong Alkaline influence (lots of leafy greens especially), if coupled with high Flax intake via a Budwig mix, is shown scientifically to elevate Metabolic and Respiratory status away from Acid and towards neutral (the author does not believe an Alkaline state is any more healthful than acidic, it is the balance which gives the reactive force, and allows the body to extract the electromagnetic energies in foods which in turn release their stored nutrients).
Altitude sickness style illness is what this Dr from New York claims he is seeing:
This Doctor, who is leading a COVID ICU, does it not sound like the symptoms you may expect to see if the 5G side effects are correct, Oxygen oscillation acceleration making uptake into the bloodstream troublesome, as the spin of Electrons become too fast to bind with Hemoglobin? It certainly seems that way to me. New York is a 5G pilot city, London, Wuhan. The Doctor says the effects are like how he envisages one would encounter if someone without acclimitisation were dropped at the top of Mount Everest…
This reflection, or speculation, of Altitude Sickness, reminded me of when I saw a documentary of Westerners climbing Mount Everest, in the Documentary I was struck that a much older Gurkha was carrying the Westerners very considerable Luggage, yet was able to smoke ceaselessly! This aligns to the statistics that are showing that a disproportionately low number of Smokers are being admitted to Hospital with COVID, are the smokers already attuned to Hypoxia like conditions and their biochemistry has been attuned coping mechanisms, like the Gurkha in Nepal? Of course he was acclimitised, but it was still staggering his body could cope in those conditions, when the younger, very fit, climber was struggling in the lower oxygen environment.
80% of those needing Ventillation in New York are dying, what if this is because 5G is in almost all the Hospitals in New York? Making the Oxygen Electrons spin too fast, forcefully adding more oxygen may only increase this damage, in those with Electron buffering insufficiency needed to take this sped up Oxygen into Hemoglobin? This paper supports this idea:
Abstract The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory infection caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus.
In this study, conserved domain analysis, homology modeling, and molecular docking were used to compare the biological roles of certain proteins of the novel coronavirus. The results showed the ORF8 and surface glycoprotein could bind to the porphyrin, respectively. At the same time, orf1ab, ORF10, and ORF3a proteins could coordinate attack the heme on the 1-beta chain of hemoglobin to dissociate the iron to form the porphyrin.
The attack will cause less and less hemoglobin that can carry oxygen and carbon dioxide. The lung cells have extremely intense poisoning and inflammatory due to the inability to exchange carbon dioxide and oxygen frequently, which eventually results in ground-glass-like lung images.
The mechanism also interfered with the normal heme anabolic pathway of the human body, is expected to result in human disease. According to the validation analysis of these finds, chloroquine could prevent orf1ab, ORF3a, and ORF10 to attack the heme to form the porphyrin, and inhibit the binding of ORF8 and surface glycoproteins to porphyrins to a certain extent, effectively relieve the symptoms of respiratory distress. Favipiravir could inhibit the envelope protein and ORF7a protein bind to porphyrin, prevent the virus from entering host cells, and catching free porphyrins. Because the novel coronavirus is dependent on porphyrins, it may originate from an ancient virus. Therefore, this research is of high value to contemporary biological experiments, disease prevention, and clinical treatment.
ChooseLife :This could be seen as supporting the 5G hypothesis, it does to me, ALARM BELLS ARE RINGING. Chloroquine is suggested again, and links the Electron issue, covered early in this ramble.
The gaseous and soluble phases of cigarette smoke are sources of oxidants that contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Chronic oxidative stress of cigarette smoking induces mucus secretion and inhibits cystic fibrosis transmembrane conductance regulator function. The increased mucus viscosity renders the airways susceptible to bacterial infections, a hallmark of chronic bronchitis. Furthermore, lungs chronically exposed to the toxic mixture of oxidants in cigarette smoke show signs of endoplasmic reticulum stress, unfolded protein response, altered ceramide metabolism, and apoptosis. Fortunately, the respiratory tract has developed effective adaptive cellular mechanisms to limit oxidant damage. Numerous antioxidant enzymes and glutathione-dependent detoxification systems are increased in healthy smokers. The regulation of the antioxidant response is largely dependent on the nuclear factor erythroid 2–related factor-2 (Nrf2) pathway. However, patients with COPD have defective Nrf2 responses. Novel therapies such as 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) to correct defective Nrf2-dependent cellular response may hold promise for patients with COPD.
ChooseLife : So, we could see the above as suggesting that healthy smokers bodies may be acclimitised to this Hypoxia type state? Like the old Nepalese Smoker being better able to cope not only with thin air, but also smoke constantly in that environment, the similarities seem stark, however the dry unproductive cough symptom is a key differentiator to HAPE symptoms.
This research area, led me to the following research, when checking into Bronchial dilation (debating in my mind if Magnesium Sulphate is contraidicatd by the above video/Doctor):
CT Features of Coronavirus Disease 2019 (COVID-19) Pneumonia in 62 Patients in Wuhan, China
A decreased lymphocyte count and an increased high-sensitivity C-reactive protein level were the most common laboratory findings.
Omega3 is known to support lymphocyte production :
Effect of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on inflammatory and immune function in postoperative patients with gastrointestinal malignancy
A meta-analysis of randomized control trials in China
In this study, lymphocytecount was significantly higher in ω-3 groups than the control groups. Omega-3 PUFAs improve the body’s defense system by the proliferation of lymphocytes, and the meta-analysis result also confirmed that the incidence of infectious complications in ω-3 groups was significantly lower than the control group.
This again says to me Metabolic Acidosis is encountered, the Lyposomes/Endosome Cargo carriers and waste removal system appears to become compromised, this is symptomtic of Cellular pH failure, as the lower pH terrain will always result in slower arrival of nutrient cargo as the Endosomes slow, and the waste removal systems slow affecting C-reactive protein as the paper above reports finding most often. Why would Sodium Bicarbonate, Magnesium Hydoxide and the like (high pH substances) not be a first line defence in these dynamics? I cannot understand why not, but a Doctor I am not!
Why does it affect Afro-Carribeans more? We’ve seen that COVID is seen to affect C-reactive protein in a very high number of cases, what if we overlay Omega 3 to this dynamic?
Relationship of Omega-3 Fatty Acids on C-Reactive Protein and Homocysteine in Haitian and African Americans with and without Type 2 Diabetes
Omega-3 fatty acids (n-3) may be protective of cardiovascular risk factors for vulnerable populations. The purpose of this study was to assess the association between n-3 with, C-reactive protein (CRP), and homocysteine (HCY) in Black minorities with and without type 2 diabetes.
African Americans had higher waist circumferences and C-reactive protein and consumed more calories as compared to Haitian Americans. Omega 3 fatty acid intake per calorie did not differ between these ethnicities, yet African Americans with low n-3 intake were three times more likely to have high C-reactive protein as compared to their counterparts [OR=3. 32 (1. 11, 9. 26) p=0.031].
Consumption of n-3 may be protective of cardiovascular risk factors such as C-reactive protein and homocysteine for certain ethnicities. Prospective studies are needed to confirm these results.
ChooseLife Notes : None of this should be construed as medical advice, or advice at all. this is just my reflections on Biological Ionisation as it relates to our current situation. The science supports that pH is very, very important, I dearly hope readers may understand this and seek to make informed choices. This period has seen a galvanising of my own diet, and my daughters, to ensure if we are infected/injured by the condition classified as COVID19 (et al) our bodies are the least likely to succumb to the worst effects some people suffer sadly.
I wish you all every wellness. May we come through this brighter and with more positive spirit than we had before, my love to you all.
Lothar Hirneise: What is your fundamental research?
Dr Johanna Budwig: In 1950, I developed Paper Chromatography of fats. With this technique for first time fats, fatty acids and lipoproteins could be detected directly even in 0.1 ml of blood. Using Co 60 I was successful in producing the first differential reaction for fatty acids, and via radioiodine producing the first direct iodine value. I also developed control of atmosphere in closed system by using gas systems which act as antioxidants. Coloring, separating effects of fats and fatty acids were further developed. Behavior was studied in blue light, red light with fluorescent dyes.
I studied the electrical behavior of the unsaturated fatty acids with their “halo” using dyes with rhodamine red. With this technique I proved that electron rich highly unsaturated Linoleic and Linolenic fatty acids (found abundantly in flax oil) are the undiscovered decisive fats in respiratory enzyme function that Otto Warburg could not find. I studied the electromotoric function of pi-electrons of the linolenic acid in the cell membranes, for all nerve function, secretions, mitosis, as well as cell breakdown. I also examined the synergism of the sulfur containing protein with the Pi-electrons of the highly unsaturated fatty acids and their significance for the formation of the hydrogen bridge between fat and protein, which represent “the only path” for fast and focused transport of electrons during respiration.
This immediately caused a furor. Cancer problem was brought in. Hydrogenated fats, which includes all Trans fatty acids proved to be respiratory poisons. This was extensively published in 1950 in many journals including “New Directions in Fat Research.”
Lothar Hirneise: What is the prime cause of Cancer?
Dr Johanna Budwig: In 1928 Dr. Otto Warburg proved that all normal cells have an absolute requirement for oxygen, but cancer cells can live without oxygen – a rule without exception. Deprive a cell 35% of its oxygen for 48 hours and it may become cancerous. Dr. Otto Warburg has made it clear that the root cause of cancer is oxygen deficiency in the cells, which creates an acidic state in the human body.
He also discovered that cancer cells are anaerobic (do not breathe oxygen), get the energy by fermenting glucose producing lactic acid and cannot survive in the presence of high levels of oxygen. Long back in 1911 Swedish scientist Torsten Thunberg postulated that sulfur containing protein (found in cottage cheese) and some unknown fat is required to attract oxygen in the cell. This fat plays a major role in the cellular respiration. For nearly half century scientists were trying to identify this unknown and mysterious fat but nobody succeeded.
Lothar Hirneise: How did you develop cancer therapy which is called Budwig Protocol?
Dr Johanna Budwig: During my research I found that the blood of seriously ill cancer patients was deficient in these unsaturated omega-3 fats (Linoleic and Linolenic fatty acids), lipoproteins, phosphatides, and hemoglobin. In addition, I noticed that cancer patients had a strange greenish-yellow substance in their blood that I could not find in the blood of healthy people. Then I wanted to develop healing program for cancer.
So I decided to straight waygo for human trials and started to give flax oil and cottage cheese to the cancer patients from four big hospitals in Münster. After just three months, patients began to improve in health and strength, the yellow green substance in their blood began to disappear, tumors gradually receded and at the same time as the nutrients began to rise. Thus I had a cure for cancer. It was a great victory and the first milestone in the battle against cancer. My treatment is based on the consumption of flax seed oil with low fat cottage cheese, raw organic diet, detoxification, mild exercise, flax oil massage and the healing powers of the sun. I have treated approx. 2500 cancer patients during last few decades. Prof. Halme of surgery clinic in Helsinki used to keep records of my patients. According to him my success was over 90% and this was achieved in cases where allopathy failed.
Lothar Hirneise: Can you tell us more about the unsaturated fatty acids and their net-like connections?
Dr. Johanna Budwig: Fatty acid is a carboxylic acid having unbranched chain of 4 to 28 carbons. The saturated fatty acids have primarily short carbon chains. In butter, coconut fat, goat fat and sheep fat the fatty acids consists of 4, 6, 8, 10 or 12 carbons, are saturated, however they are also easily co-combustible if the essential fatty acids are present. The unsaturated vital fatty acids really start with the chain with 18 carbon compounds. There are also fatty acids with up to 30 links. Fatty acids with 18 links, like in flax oil with the higher level of unsaturation, are more important for human, particularly for the brain functions of man. Linoleic acid rich in electrons is considered vital. There is a particularly high amount of energy in this double double bond of the linoleic acid. This energy wanders and is not fixed in place as it is with a chemical compound, such as with table salt. This energy, wandering between electrons and the positively charged protein with sulfur groups is an alternating association process in the electromagnetic field. This is very important. Perhaps you are familiar with the painting of Michelangelo, where God creates Adam (two fingers pointing to each other, however they do not touch). This is quantum physics, the fingers do not touch. The physicists who I know, Max Planck, or Albert Einstein, or Dessauer all represent the view that man is created by God in His image. You see in being together as human beings there is certainly also a connection without directly touching the other person. The dipolarity with a single double bond in olive oil is weaker than it is in sunflower seed oil, which is has two double bonds.
This double double bond is considered to be vital for man. However if the same chain length of 18 carbons has three unsaturated fatty acid compounds, then the electrical energy is as strong as a magnet. This electronic energy is negatively charged. The positively charged sulfur groups of the protein adhere in the unsaturated bonds where the electrons are and that is where they insert their sulfur-containing compounds.
This produces the lipoproteins. The life process is sustained in the interplay between the positively-charged particles and negatively-charged particles. In this process there is no connection, and this is our life element. If radical damage occurs at this point through fatty acids that has lost electron energy, but rather are cross-linked like a net, then the dipolarity can no longer work actively in this net. This is the deadly effect of radicals, because instead of the chains with the electron clouds they interlace a net without electron clouds, indeed with unsaturated bonds, but without dipolarity. I quickly knew that the triple unsaturated fatty acids, which were called linolenic acid, and which no one had isolated before me, had 18 links and that they did not always carry their double bonds at the same point. They have such a strong electronic energy compared to the heavier matter in the 18-link fatty acid chains, that biologically this energy is far greater than it is with the next arachidonic acid with 20 links. The highest electron collection is with the combination of linoleic-linolenic fatty acids in flax oil. The linolenic acid as conjugated (interaction of neighboring double bonds in the molecule that are separated by a single bond) fatty acid is even more effective and is even more strongly interplay with linoleic acid as it is present in the flax oil for oxygen absorption. This was relatively easy for me to verify in my experiments. I would like to emphasize this. The combination of double unsaturated linoleic acid with triple unsaturated linolenic acid is particularly well-combined in flaxseed.
Lothar Hirneise: Is it this energy that heals cancer?
Dr. Johanna Budwig: Yes, this energy is now movable and it is easily released. It is precisely this energy that heals cancer, or does not even allow it to occur. If this vital element is present then no tumor can exist. This vital element is a deciding factor in the immune system. There is no effective factor in the immune system other than the essential fatty acids.
Lothar Hirneise: What is an electron cloud?
Dr Johanna Budwig: If the enhancement of electronic energy is always higher through absorption of sun photons in the unsaturated fatty acids e.g. in linolenic fatty acids, then the power of the electrons is so high in the dipolarity in between gravity and electrons, that they lifts off of the heavy mass and floats like a cloud hence I called them electron cloud.
Lothar Hirneise: What is the significance of the cloud?
Dr. Johanna Budwig: No life form has as much energy to store the electrons and photons as does man. The electronic energy stored particularly in the vital, highly unsaturated fatty acids, is very strong life element for man. Man cannot live without them. If oils are treated with heat and harsh chemicals (during refining and hydrogenation process to increase their shelf life) then the wealth of vital electronic energy is destroyed and Trans fats are formed with net like connections. They are no longer vital fats with 18 links, but rather they form cross-links between the fatty acids like a large net, and are highly damaging to our body, do not adhare with proteins, do not attract oxygen and act like a radicals. I repeat because it is so important: I have detected particles in oils treated with steam, which indeed have a positive iodine value, but which are highly toxic for man.
Lothar Hirneise: So you preach against these toxic hydrogenated and refined oils?
Dr. Johanna Budwig: I am completely against using these “pseudo” fats – “hydrogenated”, “partially hydrogenated”. These are the biggest enemy of mankind. I had scientific proofs. The heart rejects these fats and they are deposited as inorganic fat on the heart muscle itself. They end up blocking circulation, damage heart action, inhibit cell renewal and impede the free flow of blood and lymph fluids.
But it was highly profitable business for multinationals. When I preached against these fats, they stood against me, first they tried to give me hush money and when I refused they filed many fake court cases against me. I was working for humanity and had scientific proof.I was like rock of Gibraltar in my decision; I fought and won all the cases ultimately.
Lothar Hirneise: What is mysterious marriage of sun and moon in terms of quantum physics?
Dr. Johanna Budwig: The photon, the quantum, is the smallest component of the sunlight. It is the fastest moving traveler, it speeds along with time. The photon is always in motion. Nothing can ever halt its motion. The photon is full of all colors, and can change its color and its frequency. The photon is the purest form of energy, the purest wave, can unite with a second photon when it is in resonance with the other, to form a “short-lived particle.” This particle, known as a p0 particle, can break up into two photons again, without mass, as a pure wave in motion. This is the basis for the wonderful back and forth movement between light and matter. The photon can never be pinned down to one location. This is the foundation for the Theory of Relativity.
This very active, dynamic and energetic photon can be captured by electron that are in resonance with the photon. What does that mean? Electrons are already a component of matter. They are also continuously in motion. They constantly oscillate on their own wavelength. They have their own frequency, just like a radio receiver that is set to a specific wavelength.
The electron loves photons. It attracts photons by its magnetic field. When an electrical charge moves, it always produces a magnetic field. The moving photon also has a magnetic field. Both fields attract each other when the wavelengths are in tune. The wave length of the photon – which the photon can change – must fit into the wavelength of the orbiting electron so that the orbit maintains a complete wavelength. This is eternal love between sun-god, photons and moon-goddess, electrons, this is the mysterious marriage of the sun and moon in terms of modern science.This feature is extremely interesting in terms of its physical manifestation, its biological and even its philosophical consequences. All matter has its own inherent vibration. Of course, this also applies to living substances. The energy which is being absorbed must correspond to the inherent wavelength.
The sun rays are very much in harmony with humans. It is no coincidence that we love the sun. The resonance in our biological tissue is so strongly tuned to the absorption of solar energy that there is nothing on earth that has a higher concentration of solar energy photons than humans. This enrichment with solar energy depends strongly on the “like energy” aspects, a wavelength that is compatible with humans, and this is supported when we eat foods that have electrons with electromagnetic fields that attract the photons of the sun. An abundance of these electrons, which are tuned to the solar energy frequency, exist, in many seed-oils. Scientifically these oils have even been designated as electron-rich, “essential,” highly unsaturated fats. But when we began processing fats to increase the shelf life, nobody thought about the significance that this would have for the survival and the further development of the human species. We destroyed their extremely important wealth of electrons, which are very mobile and react so wonderfully to sunlight.
Lothar Hirneise: What is the concept of “human” and “anti-human” in terms of quantum physics?
Dr. Johanna Budwig: It is interesting that in the science of quantum physics the concept of “human” has already been coined. It is “human”, with the highest accumulation of photons, always striving toward the future, who possesses within himself the highest potency of solar energy on the earth. The physicists project from mathematical equations that man, with his wealth of electrons, is directed forwards future in time.
Using mathematical equations that are valid in physics, reversing the time quotient represents the mirror image of man — the “anti-human,” whereas “man” represents the picture of highest rank in terms of physics, i.e. directed against entropy. The “anti-human” is directed back in time. The “anti-human” possesses few solar energy photons, in physical terms electron-poor, directed into the past — also in his thinking — is paralyzed in his life functions, lacks energy and strength because he is missing the electrons that are in harmony with the sun as “life-element.”
The physical processes which are generated through the use of X-rays, gamma rays, atom bombs, or cobalt radiation, are pointed in the same direction as the development toward the “anti-human,” from the perspective of physics and mathematics. The electron structure of the life functions is destroyed by these rays. According to the so-called “World Line” and the Theory of Relativity of modern physics, time and space are connected together in one equation. It is very interesting to investigate our food from this perspective. Fats that have had their electron structure destroyed to make them keep longerpromote the development of the “anti-human”and have a very detrimental effect on the future-directed, electron-rich human being, according to the “World Line diagram.” They disturb the electron exchange within living tissue because they, like tar, act as insulators against electrical conductivity, plainly deaden the life functions at the respective operative locations, e.g. in organs, and in growth centers of the body, as well as throughout the whole body. They also promotes cancer.
On the other hand, electron-rich nutrition, electron-rich highly unsaturated oils,herbs and fruits which are rich in aromatics and natural color components that correspond to the colors of the photon s of sunlight — all these increase the absorption, storage and utilization of the sun’s energy.
Lothar Hirneise: What is your view point about surgery for tumors?
Dr. Johanna Budwig: I am totally against radiation and chemo; I also reject hormonal treatment. Surgery must be considered individually. I am not a proponent of quickly making artificial anus. Conventional oncology no longer does justice to the cancer patients.
Lothar Hirneise: You also studied medicine at the age of 47 years.
Dr. Johanna Budwig: (smiling) Yes handsome! That’s right, my opponents were accusing me that how can I treat cancer patient without doctors degree. This thing pinched me, so in 1955,I joined medical school in Göttingen. There I was using my therapy very successfully in various clinics. I still remember the time I was working late one night in Göttingen, a woman came to me, with her small child whose arm was supposed to be amputated due to a tumor. I treated her and soon the subject of amputation was dismissed and the child quickly did very well.
Because I was still a medical student at this time, I was summoned to appear before the Municipal Court due to a petition that I should be prohibited from studying medicine. I explained the truth in the court. The judge rejected the case and said, “You have done a good job. In my area of jurisdiction nothing will happen to you. If it does there will be a scandal in the scientificcommunity.”
Lothar Hirneise: What do you recommend for prevention of cancer?
Dr. Johanna Budwig: Only flax oil as oil. I reject frozen and preserved meat. Fresh meat is OK. No frozen food and no bakery products. Oleolux should be used as butter. Prepare fruit juices yourself. Cheese and potatoes are OK. Also the electromagnetic environment (e.g. microwave and mobile phones etc.) in which we live is very important. I reject synthetic textiles and foam mattresses because they steal lot of forces from you. A lot of wood in home construction and woolen or silk carpets are also important. Wear gemstones, they also have good biological radiation. The environment and living conditions must be as biological (organic & natural) as possible. Regular sleep is very important.
Here are some excerpts of a paper on the functioning of Hydroxychloroquine, the drug being touted as a medicine to combat CoronaVirus. It can be seen that it’s major action, supportive of the previous data I’ve presented, is raising pH…
Hydroxychloroquine (HCQ) enters and accumulates in lysosomes along a pH gradient. In lysosomes, hydroxychloroquine inhibits the degradation of cargo derived externally (via endocytosis or phagocytosis) or internally (via the autophagy pathway) in autolysosomes by increasing the pH to prevent the activity of lysosomal enzymes. Inhibition of lysosomal activity can prevent MHC class II-mediated autoantigen presentation.
Hydroxychloroquine can also accumulate in endosomes and bind to the minor groove of double-stranded DNA. This drug can inhibit Toll-like receptor (TLR) signalling by altering the pH of endosomes (involved in TLR processing) and/or preventing TLR7 and TLR9 from binding their ligands (RNA and DNA, respectively). Hydroxychloroquine can also inhibit the activity of the nucleic acid sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) by interfering with its binding to cytosolic DNA. By preventing TLR signalling and cGAS–stimulator of interferon genes (STING) signalling, hydroxychloroquine can reduce the production of pro-inflammatory cytokines, including type I interferons.
As the pH in lysosomes is optimal for lysosomal enzymes involved in hydrolysis, by increasing the pH of endosomal compartments85, chloroquine and hydroxychloroquine might impair the maturation of lysosomes and autophagosomes and inhibit antigen presentation along the lysosomal pathway (Fig. 3).
These processes possibly occur, at least in part, through drug-mediated changes in the pH of autophagosomes and/or lysosomes, which indirectly influence immune activation; however, such a mode of action requires additional validation to aid with future drug development.
This is the drug they are saying shows great promise for Coronavirus treatment.
Here is excerpts from a paper just being released, where studies have shown 100% cure rate with CoronaVirus:
He talks about lowering the acidity in the cells…
From their prelim paper:
Specifically, the CDC research was completed in primate cells using chloroquine’s well known function of elevating endosomal pH. The results show that “We have identified chloroquine as an effective antiviral agent for SARS-CoV in cell culture conditions, as evidenced by its inhibitory effect when the drug was added prior to infection or after the initiation and establishment of infection. The fact that chloroquine exerts an antiviral effect during pre- and postinfection conditions suggest that it is likely to have both prophylactic and therapeutic advantages.
When chloroquine is added after infection, it can rapidly raise the pH and subvert on-going fusion events between virus and endosomes, thus inhibiting the infection. When added after the initiation of infection, it likely affects the endosome-mediated fusion, subsequent virus replication, or assembly and release. Specifically, rapid elevation of endosomal pH and abrogation of virus-endosome fusion may be the primary mechanism by which virus infection is prevented under post-treatment conditions.
Specifically, the virus depends on turning over the host proteins to trigger response for available building blocks to make their own proteins or nucleic acids. They break down due to low PH catalyzed by hydrolysis.
It is this part of the coronavirus’ replicative path that chloroquine inhibits. Notably, because of its nitrogen structure, chloroquine has the unique ability to get into cells and cross endosomal membranes. Once inside, nitrogens in chloroquine (and quinines in general) prevent acidification by absorbing a high amount of hydrogens that simply then interact with nitrogen and then chloroquine becomes positively charged – an ionic interaction which makes it harder for the endosome to become acidified. The result is a buffer that holds it at the higher pH and prevents it from becoming acidic enough to be functional. To summarize, because chloroquine has a multitude of extra nitrogens, once it crosses the membrane and enters an organelle, the organelle is prevented from reaching a lower pH. The organelle’s enzymes cannot work because the donor group will be a hydrogen ion, disabling the hydrolysis required for coronavirus replication. This means that all kinds of events in the cell are incapable of performing optimally, including viral replication.
Bill brought inhalation of H2O2 to the publics attention, he used it 5-6 pumps, 6 or 7x a day. To keep his Oxygen levels high, to keep the Viruses out, which come when Oxygen is down.
This was something I tried many years ago, but didn’t feel a direct or urgent need to do, so put it into my memory locker.
However, after studying this new Viral Epidemic which increasingly surrounds us, I pulled the information back to my short term memory to mix with the pH principles I had been reflecting on.
My daughter has suffered from Chronic Lung Disease as a result of being born at 24weeks gestation, so Oxygen and Viral susceptibility has been something I am used to reflecting deeply upon.
Anyway, the data shows that if you are of a lower pH, this virus group (Corona) is 10x more forceful and you are 10x more susceptible (at a pH of 6 Vs 7), so after ensuring I got my diet plans and supplements into order, I began to reflect over and over how else I can best prepare.
This is when Bill Munro came back to my mind, so I ordered 2x Nasal Vaporiser’s for about £3, and I decided that I would start taking a similar number of rounds of H2O2 as Bill did, but diluted to 1.5% with 50% Distilled water and 50% Food Grade H2O3 at 3%.
The literature for killing the Virus shows that 0.5% H2O2 kills the virus in 1 Minute, so 1.5% should be effective in 20 Seconds or thereabouts. So, to my unqualified mind, this leads me to presume that several rounds of this daily may safeguard me against this threat, if not preventing it from entering my airways entirely, then at least killing it off 5-6 times a day, minimising the intensity of the infection as best I may.
When I have talked of this method to others, peoples minds immediately seem to jump to “you are swallowing bleach”, with a shocked reaction, yet I explain that this is simply water with an extra Oxygen molecule attached, which people regularly treat their teeth with at 7% some 450% stronger than I am using. People seem to not bat an eyelid at using 4.5x stronger bleach for their teeth and vanity, yet to stave of seemingly very harsh virus people react like I am the crazy one!
This method along with Alkalising my terrain via diet and supplements are the best methods I have encountered to protect myself against this horrid viral outbreak.
If the outbreak worsens in the UK, I am intending to upgrade to the full 3%