The 10 golden mechanisms of some selected probiotics strains = anti cancer & other indications

Effect	Model Study	Listed Probiotics in CC Studies
Promotion of epithelial repair and barrier	Animal/Human [17,29,34,35,42,43]	Lactobacillus acidophilus Lactobacillus salivarius Lactobacillus plantarum Lactobacillus rhamnosus Lactobacillus kefiri Lactobacillus casei Lactobacillus delbrueckii Bifidobacterium infantis Bifidobacterium breve Bifidobacterium longum Streptococcus thermophilus
Negative regulation of inflammatory pathways promoting tumorigenesis	Animal/Human [9,10,27,28,33,36,41,42]
Increased tumor cells apoptosis	Animal/Human [12,29,31,45]
Prevention of dysbiosis and restoring eubiosis	Animal/Human [8,38,39,40,50]
Upregulation of cytokines promoting tissue repair and antitumor responses	Animal/Human [16,44,46]
Production of metabolites with positive effects on the epithelium and immune cells (SCFAs, acetate, propionate, butyrate)	Animal/Human [13,14,17,37]
Selective exclusion of pathogenic and tumorigenic bacteria (bacteriocines)	Animal/Human [18,39,62]
Inhibition of Biofilm formation and thus cell proliferation via Toll-like receptors	In vitro/Animal [28,62]
Improvement of adverse events during chemotherapy and radiation therapy	Human [53,55,56,57,58,59]
Synergistic effect with anti-cancer and immunological drugs for improving their kinetics properties	Hypothesis/Studies in progress [50,51

Lactobacillus acidophilus – Sauerkraut, Miso, Kimchi – Often added to Yogurt, Probiotics

Lactobacillus salivarius – Probiotics

Lactobacillus plantarum – Sauerkraut – Kimchi, Probiotics

Lactobacillus rhamnosus – Fermented Dry Sausages and Soy Cheeses (SE Asia especially), probiotics

Lactobacillus kefiri – Kefir based, Probiotics

Lactobacillus casei – Sauerkraut, Pickles, Yogurts, Probiotics

Lactobacillus delbrueckii – Probiotics

Bifidobacterium infantis – Probiotics

Bifidobacterium breve – Probiotics

Bifidobacterium longum – Probiotics

Streptococcus thermophilus – Dairy, Probiotics